How Antimicrobial Resistance Is Linked to Climate Change: An Overview of Two Intertwined Global Challenges

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 1681 - 1681

Published: Jan. 17, 2023

Globally, antimicrobial resistance (AMR) and climate change (CC) are two of the top health emergencies, can be considered as interlinked public priorities. The complex commonalities between AMR CC should deeply investigated in a One Health perspective. Here, we provided an overview current knowledge about relationship CC. Overall, studies included pointed out need for applying systemic approach to planetary health. Firstly, increasingly brings humans animals into contact, leading outbreaks zoonotic vector-borne diseases with pandemic potential. Although it is well-established that use human, animal environmental sectors one main drivers AMR, COVID-19 exacerbating scenario, by influencing antibiotics, personal protective equipment, biocides. This also results higher concentrations contaminants (e.g., microplastics) natural water bodies, which cannot completely removed from wastewater treatment plants, could sustain spread. Our underlined lack on direct CC, encouraged further research investigate multiple aspects involved, its effect human

Language: Английский

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Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 445, P. 130393 - 130393

Published: Nov. 14, 2022

Language: Английский

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Pharmaceuticals and personal care products (PPCPs) in the aquatic environment: Biotoxicity, determination and electrochemical treatment

Journal of Cleaner Production, Journal Year: 2023, Volume and Issue: 388, P. 135923 - 135923

Published: Jan. 6, 2023

Language: Английский

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ESKAPE in China: epidemiology and characteristics of antibiotic resistance

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: Feb. 15, 2024

The escalation of antibiotic resistance and the diminishing antimicrobial pipeline have emerged as significant threats to public health. ESKAPE pathogens - Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. were initially identified critical multidrug-resistant bacteria, demanding urgently effective therapies. Despite introduction various new antibiotics adjuvants, such innovative β-lactamase inhibitors, these organisms continue pose substantial therapeutic challenges. People's Republic China, a country facing severe bacterial situation, has undergone series changes findings in recent years terms prevalence, transmission characteristics mechanisms resistant bacteria. increasing levels population mobility not only shaped unique prevalence within China but also indirectly reflected global patterns antibiotic-resistant dissemination. What's more, vast nation, exhibits variations bacteria across different provinces regions. In this review, we examine current epidemiology important group pathogens, delving into relevant recently introduced that impact their clinical utility China.

Language: Английский

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Phage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 6, 2024

Abstract Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of immune response on clinical effectiveness. Here, we develop mouse model assess phage treatment using cocktail five phages from Myoviridae and Siphoviridae families that target Vancomycin-Resistant Enterococcus gut colonization. Phage significantly reduces fecal bacterial loads Enterococcus. We also characterize responses elicited following administration cocktail. While minimal innate are observed after administration, two rounds induces phage-specific neutralizing antibodies accelerate clearance tissues. Interestingly, myophages in our induce more robust antibody than siphophages. This anti-phage immunity effectiveness murine model. Collectively, this study shows may be an important consideration development cocktails for therapeutic use.

Language: Английский

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Global status of antimicrobial resistance in clinical Enterococcus faecalis isolates: systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 24, 2024

Due to the increasing emergence of antibiotic resistance in Enterococcus faecalis (E. faecalis), it indicated as potentially opportunistic pathogen causing various healthcare-associated and life-threatening diseases around world. The aim this meta-analysis was evaluate weighted pooled rates clinical E. isolates based on over time, areas, antimicrobial susceptibility testing (AST), infection source. We searched studies PubMed, Scopus, Web Science (November 30, 2022). All statistical analyses were carried out using package R. analysis encompassed a total 74 conducted 28 countries. According meta-regression, chloramphenicol, fosfomycin, imipenem, linezolid, minocycline, norfloxacin, quinupristin-dalfopristin, tetracycline rate increased time. Analysis revealed statistically significant differences for ampicillin, erythromycin, gentamicin, penicillin, rifampicin, teicoplanin, tetracycline, vancomycin across Globally, prevalence drug resistant strains are increase Daptomycin tigecycline can be an effective agent treatment infections. Considering low continents Europe Australia, is suggested take advantage their preventive strategies order obtain efficient results other places with high resistance.

Language: Английский

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Unraveling Antimicrobial Resistance Dynamics in Mycoplasma gallisepticum: Insights Into Antibiotic and Disinfectant Interactions

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

ABSTRACT A major risk to the poultry industry is antimicrobial resistance (AMR), specifically with regard Mycoplasma gallisepticum (MG) infections. The sensitivity patterns of 100 MG isolates biocides and antibiotics were examined in this study clarify interactions between agents mechanisms. activity against was assessed using broth microdilution, results are shown as minimum inhibitory concentration (MIC) for each strain, MIC distribution (range), 50 , and/or 90 . statistical associations MICs investigated regression model analysis correlation coefficients. absence a cell wall inherently confers beta‐lactams, thereby necessitating utilization enrofloxacin, difloxacin, flumequine, oxytetracycline, chlortetracycline, doxycycline, tylosin, tilmicosin, tylvalosin, erythromycin, spiramycin, tiamulin, lincomycin, spectinomycin dihydrostreptomycin. These exhibited values 0.5, 0.12, 0.062, 0.031, 0.016, 16, 1, 0.008, 2, 0.5 32, respectively. In addition antibiotics, disinfectants have garnered attention their contribution development AMR MG. Notably, formalin, phenol, NADES, Halamid, Virkon‐S, MicroSet SteriSet 125, 500, 31.25, 15.63, 7.81 62.5, Significant positive correlations direct identified various antibiotic resistance, coefficients ranging from 0.098 1.176. This research highlights intricate nature profiles underscores necessity thorough understanding interactions. finding emphasizes importance managing emerging stemming disinfectant misuse farms prevent additional constraints on treatment options.

Language: Английский

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Effects of the COVID-19 pandemic on the environment, waste management, and energy sectors: a deeper look into the long-term impacts

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(31), P. 46438 - 46457

Published: May 2, 2022

Language: Английский

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COVID-19 at a Glance: An Up-to-Date Overview on Variants, Drug Design and Therapies

Viruses, Journal Year: 2022, Volume and Issue: 14(3), P. 573 - 573

Published: March 10, 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the Coronavirus family which caused worldwide pandemic human illness coronavirus disease 2019 (COVID-19). Presumably emerging at end 2019, it poses severe threat to public health and safety, with high incidence transmission, predominately through aerosols and/or direct contact infected surfaces. In 2020, search for vaccines began, leading obtaining of, date, about twenty COVID-19 approved use in least one country. However, continues spread new genetic mutations variants have been discovered, requiring pharmacological treatments. The most common therapies are represented by antiviral antimalarial agents, antibiotics, immunomodulators, angiotensin II receptor blockers, bradykinin B2 antagonists corticosteroids. addition, nutraceuticals, vitamins D C, omega-3 fatty acids probiotics under study. Finally, drug repositioning, concerns investigation existing drugs therapeutic target indications, has widely proposed literature therapies. Considering importance this ongoing global emergency, review aims offer synthetic up-to-date overview regarding diagnoses, COVID-19, particular attention paid adopted

Language: Английский

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Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 276 - 276

Published: Feb. 19, 2022

In addition to the pathogenesis of SARS-CoV-2, bacterial co-infection plays an essential role in incidence and progression SARS-CoV-2 infections by increasing severity infection, as well disease symptoms, death rate antimicrobial resistance (AMR). The current study was conducted a tertiary-care hospital Lahore, Pakistan, among hospitalized COVID-19 patients see prevalence co-infections AMR rates different isolated bacteria. Clinical samples for laboratory diagnosis were collected from 1165 patients, which 423 found be positive various infections. Most bacteria Gram-negative rods (n = 366), followed Gram-positive cocci 57). A significant association (p < 0.05) noted between co-infections. Staphylococcus aureus (S. aureus) showed high against tetracycline (61.7%), Streptococcus pyogenes penicillin (100%), E. coli Amp-clavulanic acid (88.72%), Klebsiella pneumoniae ampicillin Pseudomonas aeruginosa ciprofloxacin (75.40%). Acinetobacter baumannii 100% resistant majority tested antibiotics. methicillin-resistant S. (MRSA) 14.7%. topmost symptoms >50% fever, fatigue, dyspnea chest pain with co-infected patients. results comparatively AMR, may become severe health-related issue future. Therefore, strict compliance antibiotic usage employment stewardship programs at every public or private institutional level are recommended.

Language: Английский

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