Pentachlorophenol exposure, plasma metabolomic markers, and gestational diabetes mellitus: Association and potential mediation analyses DOI Creative Commons
Juan Wen,

Shijie Geng,

Juan Mu

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126069 - 126069

Published: March 14, 2025

Language: Английский

Dihydroxyl modified UiO-66 as dispersive solid-phase extraction sorbent coupled with ultra-high performance liquid chromatography tandem mass spectrometry for detection of neonicotinoid insecticides DOI
Ting Li,

Tao Ning,

Xinyu Liu

et al.

Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1727, P. 464970 - 464970

Published: May 7, 2024

Language: Английский

Citations

3

Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis DOI Creative Commons
Juan Wen, Qiao Liu,

Shijie Geng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 280, P. 116561 - 116561

Published: June 12, 2024

Imidacloprid (IMI), a commonly utilized neonicotinoid insecticide, has been identified to adversely impact glucose homeostasis. Pregnant women are believed be more sensitive toxins than non-pregnant women, and the of IMI exposure on gestational hyperglycemia remain unclear. To explore impact, pregnant mice fed high-fat diet were exposed different doses (0.06, 0.6, 6 mg/kg bw/day) by gavage. Glucose homeostasis-related parameters measured. The homeostasis influenced treatment was explored through integrating gut microbiota, metabolomic transcriptomic analysis. Results showed that IMI-H (6 notably restricted weight gain perturbed characterized reduced tolerance insulin sensitivity, alongside elevated levels fasting blood insulin. Multi-omics analysis revealed induced significant changes in richness composition microbiome. metabolite profiles serum samples cecal contents, transcriptome liver ileum all affected treatment. altered metabolites genes exhibited correlations with parameters. These differential implicated various metabolic pathways including bile secretion, glucagon signaling pathway, lipid metabolism, fatty acid metabolism. Significant observed between microbiota caecum metabolome as well transcriptome. For example, abundance Oscillibacter strongly correlated microflora-related (Icosenoic acid, Lysosulfatide, fluticasone) (Grin3b, Lifr, Spta1). Together, resulted microbial composition, along alterations certain associated process, which may promote hyperglycemia.

Language: Английский

Citations

3

Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study DOI Creative Commons
Maoti Wei, Ying Wen, Zhuxia Zhang

et al.

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Perspective on neonicotinoid insecticides in human exposure and risk assessment DOI Open Access

Shaofang Song,

Yuhan Yue,

Qiaoli Jiang

et al.

Journal of Environmental Exposure Assessment, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 19, 2025

This perspective presents first-hand research insights into the pervasive environmental distribution of neonicotinoid insecticides (NEOs) and their consequent human exposure. Our findings reveal widespread NEO detection across biological matrices, indicating potential health risks highlighting critical gaps in current risk assessment paradigms. We identify an urgent need for longitudinal epidemiological studies, particularly focusing on vulnerable populations, to comprehensively assess NEO-related outcomes. These scientific should inform evidence-based policy reforms management strategies effectively protect both public integrity.

Language: Английский

Citations

0

Pentachlorophenol exposure, plasma metabolomic markers, and gestational diabetes mellitus: Association and potential mediation analyses DOI Creative Commons
Juan Wen,

Shijie Geng,

Juan Mu

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126069 - 126069

Published: March 14, 2025

Language: Английский

Citations

0