Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 19, 2025

Language: Английский

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Integration of transcriptomic and metabolomic reveals carbonate alkalinity stress responses in the hepatopancreas of Litopenaeus vannamei

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 260, P. 106569 - 106569

Published: May 17, 2023

Language: Английский

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Histological, Physiological and Transcriptomic Analysis Reveal the Acute Alkalinity Stress of the Gill and Hepatopancreas of Litopenaeus vannamei

Marine Biotechnology, Journal Year: 2023, Volume and Issue: 25(4), P. 588 - 602

Published: June 27, 2023

Language: Английский

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Effects of chronic saline-alkaline stress on gill, liver and intestinal histology, biochemical, and immune indexes in Amur minnow (Phoxinus lagowskii)

Aquaculture, Journal Year: 2023, Volume and Issue: 579, P. 740153 - 740153

Published: Sept. 26, 2023

Language: Английский

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Acute stress response in gill of Pacific white shrimp Litopenaeus vannamei to high alkalinity

Aquaculture, Journal Year: 2024, Volume and Issue: 586, P. 740766 - 740766

Published: March 5, 2024

Language: Английский

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Analysis revealed the molecular mechanism of oxidative stress-autophagy-induced liver injury caused by high alkalinity: integrated whole hepatic transcriptome and metabolome

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

Introduction High-alkalinity water is a serious health hazard for fish and can cause oxidative stress metabolic dysregulation in livers. However, the molecular mechanism of liver damage caused by high alkalinity unclear. Methods In this study, 180 carp were randomly divided into control (C) group high-alkalinity (A25) cultured 56 days. High-alkalinity-induced injury was analysed using histopathological, whole-transcriptome, metabolomic analyses. Results Many autophagic bodies abundant mitochondrial membrane observed A25 group. High decreased superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activity total antioxidant capacity (T-AOC) increased malondialdehyde (MDA) content tissues, causing liver. Transcriptome analysis revealed 61 differentially expressed microRNAs (miRNAs) 4008 mRNAs. Kyoto Encyclopedia Genes Genomes (KEGG) enrichment that mammalian target rapamycin (mTOR), forkhead box O (FoxO), mitogen-activated protein kinase (MAPK), autophagy signalling pathway mechanisms involved. causes results Bioinformatic predictions indicated Unc-51 Like Kinase 2 (ULK2) potential gene miR-140-5p, demonstrating triggered through miR-140-5p–ULK2 axis. Metabolomic concentrations cortisol 21-sulfate beta-aminopropionitrile significantly increased, while those creatine uracil decreased. Discussion The effects on whole-transcriptome miRNA-mRNA networks metabolomics approaches. Our study provides new insights highly alkaline water.

Language: Английский

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Multi-omics combined with physiological and biochemical analyses provide new insights into the molecular mechanisms of nano‑selenium on rainbow trout head kidney against heat stress

Aquaculture, Journal Year: 2025, Volume and Issue: 599, P. 742095 - 742095

Published: Jan. 10, 2025

Language: Английский

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Acute alkalinity stress induces functional damage and alters immune metabolic pathways in the gill tissue of spotted scat (Scatophagus argus)

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742186 - 742186

Published: Jan. 1, 2025

Language: Английский

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Comparative mechanisms of acute high-alkalinity stress on the normal and hybrid populations of pacific white shrimp (Litopenaeus vannamei)

Frontiers in Marine Science, Journal Year: 2025, Volume and Issue: 12

Published: March 7, 2025

In recent years, as anthropogenic activities the alkalinity of water bodies has intensified, which seriously affected development aquaculture. Cross breeding can inherit good traits parents and develop stronger resistance to stress. Therefore, we investigated advantages hybrid population (TH) Litopenaeus vannamei over normal variety (TC) in terms survival rate, morphological changes gill tissue, ion transport, energy metabolism. After culture same environment, two species shrimp were subjected acute exposure levels 50 mg/L, 200 350 mg/L for 24 hours, samples taken at 0, 4, 8, 12, h, respectively. The study showed that under stress, TH group had a higher greater hemolymph urea nitrogen content, better tissue integrity compared TC group. also exhibited increased key enzymes such Na + /K ATPase Ca 2+ /Mg ATPase, along with elevated nitrogen, arginase. Additionally, expression genes, including NKA (Na -ATPase), CA (carbonic anhydrase), HSPs (heat shock proteins) was upregulated group, suggests these genes may play crucial role improving tolerance high-alkalinity environments. Our results demonstrated concentration alkaline metabolism ability stress than population. This provide theoretical reference varieties L. .

Language: Английский

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The importance of multi-omics approaches for the health assessment of freshwater ecosystems

Molecular & Cellular Toxicology, Journal Year: 2022, Volume and Issue: 19(1), P. 3 - 11

Published: Sept. 6, 2022

Language: Английский

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