Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 157 - 184
Published: Sept. 8, 2023
Language: Английский
Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10
Published: June 15, 2023
Carbapenem resistance (CR) is a major global health concern. CR growing challenge in clinical settings due to its rapid dissemination and low treatment options. The characterization of molecular mechanisms epidemiology are highly studied. Nevertheless, little known about the spread food-producing animals, seafood, aquaculture, wildlife, their environment, or risks associated with humans. In this review, we discuss detection carbapenem-resistant organisms action pigs, cattle, poultry, seafood products, companion wildlife. We also pointed out One Health approach as strategy attempt emergency dispersion carbapenem-resistance sector determine role carbapenem-producing bacteria animals among human public risk. A higher occurrence carbapenem enzymes poultry swine has been previously reported. Studies related have highlighted P. mirabilis, E. coli , K. pneumoniae NDM-5- NDM-1-producing bacteria, which lead resistance. OXA-181, IMP-27, VIM-1 detected pigs. rare cattle. However, OXA- NDM-producing mainly A. baumannii cattle's leading causes high prevalence reported wildlife suggesting cross-species transmission genes. Antibiotic-resistant aquatic environments should be considered because they may act reservoirs for It urgent implement worldwide make an effort contain
Language: Английский
Citations
27
Eurosurveillance, Journal Year: 2023, Volume and Issue: 28(10)
Published: March 9, 2023
BackgroundCarbapenemase-producing Enterobacterales (CPE) are rapidly increasing worldwide, also in Europe. Although prevalence of CPE Germany is comparatively low, the National Reference Centre for Multidrug-resistant Gram-negative Bacteria noted annually numbers NDM-5-producing Escherichia coli isolates.AimAs part our ongoing surveillance programme, we characterised E. isolates received between 2013 and 2019 using whole genome sequencing (WGS).MethodsFrom 329 identified coli, 224 from known geographical locations were subjected to Illumina WGS. Analyses 222 sequenced included multilocus sequence typing (MLST), core (cg)MLST single-nucleotide polymorphism (SNP)-based analyses.ResultsResults cgMLST revealed genetically distinct clusters many 43 detected types (ST), which ST167, ST410, ST405 ST361 predominated. The SNP-based phylogenetic analyses combined with information sporadic cases nosocomial transmission on a small spatial scale. However, large corresponding clonal dissemination strains consecutive years different regions Germany.ConclusionOccurrence rose Germany, was extent due increased belonging international high-risk clones ST361. Of particular concern supra-regional these epidemic clones. Available suggest community spread highlighting importance epidemiological investigation an integrated system One Health framework.
Language: Английский
Citations
17
International Journal of Antimicrobial Agents, Journal Year: 2024, Volume and Issue: 64(3), P. 107251 - 107251
Published: Sept. 1, 2024
Antimicrobial resistance (AMR) has emerged as a critical global health challenge. However, the significance of AMR is not limited to humans and domestic animals but extends wildlife environment. Based on analysis more than 200 peer-reviewed papers, this review provides comprehensive current insights into detection clinically significant antimicrobial resistant bacteria genes in wild mammals, birds reptiles worldwide. The also examines overlooked roles emergence transmission. In wildlife, potentially driven by anthropogenic activity, agricultural environmental factors, well natural evolution. This highlights surveillance identifies species geographic foci gaps, finally demonstrates value multifaceted One Health strategies if we are curtail further escalation globally.
Language: Английский
Citations
7
Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 1699 - 1728
Published: May 1, 2024
Background: The World Health Organization (WHO) has classified carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa ( P. ), and Acinetobacter baumannii A. ) as high-priority pathogens, bacteria (CRB) have been reported to spread between humans, animals, the environment. Objective: This study aimed conduct a systematic review of carbapenem resistance in foods, environment on African continent provide recommendations perspectives for better prevention control Africa. Results: A total 137 research articles collected from 2009 2023 were selected this review, including reporting animals (81/137; 59.1%), (66/137; 48.2%), foods (26/137; 19%). Carbapenem-resistant bacterial species belonged 31 genera 17 families, mainly Escherichia spp. (68/127; 53.5%); Klebsiella (45/127; 35.4%); (20/127; 15.7%), Enterobacter (19/127; 15%) (15/127; 11.8%). prevalence CRBs by country ranged 1.1% 48.5%, pooled isolated animal-environment-food Africa was 19.1% (2804/14,684; Standard Deviation = 15). Twenty carbapenemase families belonging A, B, C, D Ambler classes reported, genes bla OXA (44/84; 52.4%), NDM (34/84; 40.5%), SHV (23/84; 27.4%), KPC (22/84; 26.2%), VIM (19/84; 22.6%), IMP (12/84; 14.3%) families. mobile genetic elements (MGE) carrying carbapenemase-encoding included plasmids (16/19; 84.2%), integrons (3/19; 15.8%), transposons insertion sequences (2/19; 10.5%). OXA-48 often carried (60kb-65kb) IncL/M-type pOXA-48 plasmids, while NDM-5 (45– 50kb) IncX-type plasmids. Moreover, 25 investigated virulent hypervirulent that multiple virulence factors. Conclusion: Animal-environment-food ecosystems would constitute reservoirs involved human infections. One approach constant collaboration governments are necessary drastically reduce mortality rates linked antimicrobial resistance. Keywords: resistance, animal-environment-food, Africa, element, gene
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: April 20, 2024
The emergence of plasmid-mediated tigecycline resistance gene tet(X4) among clinically relevant bacteria has promoted significant concerns, as is considered a last-resort drug against serious infections caused by multidrug-resistant bacteria. We herein focused on the isolation and molecular characterization tet(X4)-positive Klebsiella pneumoniae (K. pneumoniae) Escherichia coli (E. coli) in wild bird populations with anthropogenic interaction Faisalabad, Pakistan. A total 150 birds including black kites (Milvus migrans) house crows (Corvus splendens) were screened for presence K. E. coli. found two one isolate carrying originating from kites. combination short- long-read sequencing strategies showed that was located broad host range IncFII plasmid family isolates whereas an IncFII-IncFIB hybrid also integrative conjugative element ICEKp2 KP8336. demonstrate first description WHO critical-priority pathogen birds. convergence virulence associated known contact should be further investigated to evaluate potential epidemiological implications. risk global transmission warrant comprehensive evaluation emphasizes need effective mitigation reduce anthropogenic-driven dissemination AMR environment.
Language: Английский
Citations
5
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28052 - e28052
Published: March 17, 2024
BackgroundCarbapenem resistance is epidemic worldwide, these last resort antimicrobials are listed in the WHO 'watch group' with higher potential. During years 2017-18 Pakistan Antimicrobial Resistance Surveillance System reported an increase carbapenem resistance. However, a comprehensive information on prevalence and molecular epidemiology of not available. This systematic review meta-analysis aimed to report current situation its treatment options.MethodsIn this meta-analysis, we investigated pooled (PPr) Enterobacteriaceae non-Enterobacteriaceae by organizing available data, from Web Science PubMed April 2, 2020, various groups subgroups including species, years, provinces, extended spectrum β-lactamase production, clinical presentation, carbapenemase metallo-β-lactamase New Delhi (NDM) prevalence. Moreover, descriptively reviewed Pakistan. Lastly, statistically explored different options for resistant infections. We used R package 'metafor' influence diagnostics, options.ResultsFrom two academic databases identified 343 studies. Eighty-eight studies were selected meta-analysis. Seventy-four phenotypic analysis, 36 genotypic 31 options. PPr-ID 12% [0.12 (0.07, 0.16)] was observed more recorded Klebsiella pneumoniae 24% [0.24 (0.05, 0.44)] followed 9% [0.09 (−0.03, 0.20)] Escherichia coli. decades striking PPr i.e., 0% [0.00 (−0.02, 0.03)] 36% [0.36 (0.17, 0.56)]. blaNDM 15% [0.15 (0.06, 0.23)] naive isolates found be fundamental genetic determinant Polymyxin B, colistin, tigecycline, fosfomycin as suggested multidrug infections responding carbapenems.ConclusionIn conclusion, that NDM-1 producing increasing Meta-analysis showed metallo-β-lactamases E. coli ST405 K. sequence type11 major clones. Number inconsistency following CLSI guidelines potential limitations A National antimicrobial (AMR) surveillance strategy based One Health urgently needed check any future AMR crisis
Language: Английский
Citations
4
Journal of Applied Microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract Antimicrobial resistance (AMR), arising from decades of imprudent anthropogenic use antimicrobials in healthcare and agriculture, is considered one the greatest One Health crises facing globally. pollutants released human-associated sources are intensifying evolution environment. Due to various ecological factors, wildlife interact with these polluted ecosystems, acquiring resistant bacteria genes. Although recognised reservoirs disseminators AMR environment, current surveillance systems still primarily focus on clinical agricultural settings, neglecting this environmental dimension. Wildlife can serve as valuable sentinels reflecting ecosystem health, effectiveness mitigation strategies. This review explores knowledge gaps surrounding factors influencing acquisition dissemination wildlife, highlights limitations policy instruments that do not sufficiently address component AMR. We discuss underutilised opportunity using sentinel species a holistic, Health-centred system. By better integrating into systematic policy, leveraging advances high-throughput technologies, we track predict evolution, assess impacts, understand complex dynamics transmission across ecosystems.
Language: Английский
Citations
0
Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109320 - 109320
Published: Feb. 12, 2025
Migratory birds play a pivotal role in the global dissemination of antimicrobial resistance genes (ARGs), with shorebirds relying on coastal wetlands during their long-distance migrations, environments often contaminated and conducive to ARG transmission. However, systematic investigations into (AMR) remain scarce. During spring autumn 2023, we collected 893 throat cloacal swabs from 480 shorebirds, representing 28 species, at Chongming Dongtan, critical stopover along East Asian-Australasian Flyway. Our analysis identified six strains, including four extra-intestinal pathogenic E. coli (ExPEC) two K. pneumoniae, that exhibited third-generation cephalosporins, three ExPEC strains exhibiting significant virulence Galleria mellonella infection assays. We conjugative plasmids: E042113F_p1, carrying blaCMY-2 gene coli, M50_p2, blaKPC-2 hypervirulent pneumoniae plasmid harboring aerobactin system. Bioinformatic experimental analyses confirmed these plasmids could transfer without any fitness cost, remaining stable for least 30 passages. Surprisingly, genomic tracing revealed among similar E042113F_p1 (blaCMY-2), earliest was Chinese swallow 2015, subsequent detections wild Mongolia (2017), Russia (2018), Australia (2019). Notably, E04-CMY-like/M50-KPC-like predominantly originated human sources, underscoring activity cross-species transmission AMR. This human-mediated elements wildlife posed substantial risk amplifying disseminating AMR through long-range migratory bird movements, highlighting urgent need international collaboration under One Health framework. Integrated surveillance, environmental management, stringent antibiotic stewardship are mitigating risks by spreading across ecosystems.
Language: Английский
Citations
0
EcoHealth, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Language: Английский
Citations
0
Applied and Environmental Microbiology, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 13, 2024
A One Health perspective is crucial to understand the extent of antimicrobial resistance (AMR) globally, and investigation AMR in environment has been increasing recent years. However, most studies have focused on waterways that are directly polluted by sewage, industrial manufacturing, or agricultural activities. Therefore, there remains a lack knowledge about more natural, less overtly impacted environments. Through phenotypic genotypic Escherichia coli , this study adds our understanding patterns these types environments, including over time series, showed complex biotic abiotic factors contribute observed. Our further emphasizes importance incorporating surveillance microbes freshwater environments order better comprehend potential risks for both human animal health how may serve as sentinel future clinical infections.
Language: Английский
Citations
3