Evaluation of adsorption performance and mechanisms of a highly effective 3D boron-doped graphene composite for amitriptyline pharmaceutical removal

Journal of Environmental Management, Journal Year: 2023, Volume and Issue: 344, P. 118363 - 118363

Published: July 4, 2023

Three-dimensional heteroatom-doped graphene presents a state-of-the-art approach for effective remediation of pharmaceutical wastewater on account its distinguished adsorption and physicochemical attributes. Amitriptyline is an emerging tricyclic antidepressant pollutant posing severe risks to living habitats through water supply food chain. With ultra-large surface area plentiful chemical functional groups, oxide favorable adsorbent decontaminating polluted water. Herein, new boron-doped composite reinforced with carboxymethyl cellulose was successfully developed via solution-based synthesis. Characterization study revealed that the formed by sheets intertwined into porous network engrafted 13.37 at% boron. The has zero charge at pH 6 contained various groups favoring attachment amitriptyline. It also found mere 10 mg able achieve relatively high amitriptyline removal (89.31%) 50 ppm solution concentration 30 °C. attained equilibrium within 60 min across concentrations ranging from 300 ppm. kinetic were well correlated pseudo-second-order Langmuir models, respectively, portraying highest capacity 737.4 mg/g. Notably, predominant mechanism chemisorption assisted physisorption contributed outstanding saturated sufficiently regenerated using ethanol eluent. results highlighted impressive performance as-synthesized in treating amitriptyline-containing waste effluent.

Language: Английский

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Long and Short Duration Exposures to the Selective Serotonin Reuptake Inhibitors (SSRIs) Fluoxetine, Paroxetine and Sertraline at Environmentally Relevant Concentrations Lead to Adverse Effects on Zebrafish Behaviour and Reproduction

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 151 - 151

Published: Feb. 4, 2023

Selective serotonin reuptake inhibitors (SSRIs) are currently the most prescribed class of psychotropic medications. Their increased global manufacture and use have become growing concerns for aquatic toxicologists environmental biologists, who assess both direct indirect effects substances on environment human health. In order to potential impact environmentally relevant levels SSRIs fish development, behaviour reproduction, we exposed juvenile adult zebrafish a select group using two separate exposure paradigms. first paradigm, were Fluoxetine (Prozac), Paroxetine (Paxil), Sertraline (Zoloft) or mixture three beginning at (10 µg/L) 135 days (long-term exposure) 5 post fertilization (dpf). second matching concentrations same 35 (short-term exposure). The long-term paradigm proved little no overt effect growth development sub-lethal 100 µg/L). However, stress/anxiety response (novel tank tests) reproduction (fecundity fertility) dramatically reduced. Importantly, short-term reproductively mature led similar adverse stress reproduction. Following short long duration paradigms, 2-week washout period small reduction in effects. These findings highlight negatively population dynamics may be particular value should they found other species environment.

Language: Английский

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Long-Term Exposure to SSRI Citalopram Induces Neurotoxic Effects in Zebrafish

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(17), P. 12380 - 12390

Published: Aug. 19, 2022

Residual antidepressants are of increasing concern worldwide, yet critical information on their long-term neurotoxic impacts nontarget aquatic animals is lacking. Here, we investigated the effects (from 0 to 150 days postfertilization) selective serotonin reuptake inhibitor citalopram (0.1–100 μg/L) motor function, learning, and memory in zebrafish over two generations explored reversibility effect F1 larvae. Unlike F0+ larvae, found that F1+ larvae displayed decreased sensorimotor performance when continuously exposed at 100 μg/L. No adverse were F1– after they transferred a clean medium. Whole-mount immunofluorescence assays suggested impairments related axonal projections spinal neurons (MNs). For adults, exposure mainly caused male-specific declines motor, performance. Analysis serotonergic cholinergic MNs revealed no significant changes male cord. In contrast, number glutamatergic decreased, likely associated with impairment function. Additionally, treatment μg/L significantly reduced dopaminergic neurons, but neuronal apoptosis was observed adult telencephalon. Overall, this study provides neurobehavioral evidence novel insights into mechanisms may facilitate assessment environmental health risks posed by citalopram-containing antidepressant drugs.

Language: Английский

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Altered reproductive behaviour in siamese fighting fish (Betta splendens) after exposure to different level of turbidity derived from palm oil mill effluent

Applied Animal Behaviour Science, Journal Year: 2024, Volume and Issue: 276, P. 106308 - 106308

Published: June 6, 2024

Language: Английский

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Combined Molecular Toxicity Mechanism of Emerging Pollutant Mixtures

Published: Jan. 14, 2025

Pharmaceuticals and personal care products (PPCPs) compounds are vital components of daily life modern health care. Over the past 20–25 years, a substantial amount work has been done to elucidate occurrence, bioaccumulation, fate, risks PPCPs in environment. The ubiquity most environment their potential deleterious effects on ecological human have engaged community scientists government regulators. Nontarget organisms continuously exposed multiple PPCP compounds, evidence for underestimated toxicity from such mixtures is mounting. Yet, increasing research around world still focuses overwhelmingly molecular mechanism single PPCP, scientific about combined limited date. This chapter provides an overview "state-of-the-art" literature data mechanisms PPCPs, with special emphasis mixture scenarios.

Language: Английский

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A novel data-driven screening method of antidepressants stability in wastewater and the guidance of environmental regulations

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109427 - 109427

Published: March 1, 2025

Wastewater-based epidemiology (WBE) represents a powerful technique for quantifying the attenuation characteristics and consumption of pharmaceuticals. In addition to WBE, no further methods have been developed assess wastewater stability related antidepressants (ADs). this study, biodegradability, solubility, adsorption or partition 66 ADs were objectively scored according relevant guidelines Organisation Economic Cooperation Development. An assessment framework MSSL-RealFormer classification model constructed based on physicochemical properties predict quantitative structure-activity relationship. The exhibited markedly higher prediction accuracy than traditional methods. Furthermore, 15 high-stable in with low high identified. SHapley Additive exPlanation method demonstrated that group hydrophobicity, electrostatic van der Waals forces exerted significant influence stability. And molecular was found be significantly correlated A combination density functional theory employed identify 17 transformation products nine medium- low-stable wastewater. Ecological Structure Activity Relationships bupropion, tapentadol chlorpheniramine acute toxicity aquatic food chain. novel deep learning rapidly screen correlation between their structures. It is anticipated prove favorable tool optimizing screening

Language: Английский

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Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

In recent years, the increasing number of infertility cases has led to a greater research focus on reproductive toxicity drugs due fact that some classes pharmacotherapeutic agents have been found exert deleterious effects system. Depressive disorders are class common mental illnesses seriously damage human health. The variety antidepressant is large and incidence adverse high. Selective serotonin reuptake inhibitors (SSRIs), as first-line for treatment depression, remarkable efficacy, but at same time there widespread abuse them, which not only creates an unfavorable impact one’s own system, also may cause other non-target populations through pathways, such water column. review provides introduction SSRIs from aspects male female germ cell genesis, embryonic development, system maturation, environmental contamination, it briefly describes potential mechanisms underlying SSRI-induced toxicity.

Language: Английский

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Antidepressants and COVID-19: Increased use, occurrence in water and effects and consequences on aquatic environment. A review

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 175993 - 175993

Published: Sept. 6, 2024

Language: Английский

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Hazard and health risk assessment of exposure to pharmaceutical active compounds via toxicological evaluation by zebrafish

Environmental Pollution, Journal Year: 2022, Volume and Issue: 324, P. 120698 - 120698

Published: Nov. 23, 2022

Language: Английский

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Integrated Studies on Male Reproductive Toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 58(1), P. 194 - 206

Published: Dec. 19, 2023

Bis(2-ethylhexyl)tetrabromophthalate (TBPH) has been widely detected in the environment and organisms; thus, its toxic effects on male reproduction were systematically studied. First, we found that TBPH can stably bind to androgen receptor (AR) based silico molecular docking results observed an antagonistic activity, but not agonistic AR signaling pathway using a constructed AR-GRIP1 yeast assay. Subsequently, validated adverse germ cells by observing inhibited production proliferation Leydig upon vitro exposure affected general motility motive tracks of zebrafish sperm ex vivo exposure. Finally, reproductive toxicity was demonstrated reduced mating behavior F0 generation when paired with unexposed females abnormal development their offspring. In addition, impaired also observed, which may be related disturbed homeostasis sex hormones. Notably, specifically suppressed brain provides further evidence for as above-mentioned. These confirmed through classical nuclear receptor-mediated pathway, would helpful assessing ecological health risks TBPH.

Language: Английский

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