Toxics,
Journal Year:
2025,
Volume and Issue:
13(3), P. 181 - 181
Published: Feb. 28, 2025
Mussels
serve
as
indicators
of
anthropogenic
chemical
pollution;
however,
the
effects
microplastics
and
plastic-related
chemicals
on
their
health
performance
remain
an
emerging
issue.
In
this
study,
mussels
were
exposed
to
a
polyamide
(PA;
5
μg/L)
tricresyl
phosphate
(TCP;
1
for
28
days.
The
exposures
two
contaminants
performed
independently
or
in
combination
lasted
results
showed
that
independent
exposure
altered
enzyme
activities
more
significantly
than
combined
one.
Exposure
PA
(p
<
0.05)
inhibited
antioxidant
catalase
(CAT)
by
43.5%
neurotransmitter
acetylcholinesterase
(AChE)
40.6%,
while
TCP
specifically
carboxylesterase
(CE)
activity
38.5%,
all
respect
solvent
control.
When
both
pollutants
combined,
most
biomarker
responses
similar
control
levels.
To
further
investigate
if
mussels’
response
(here,
compounds
only)
could
be
population-specific,
comparative
study
between
Atlantic
Mediterranean
was
included.
Firstly,
baseline
detoxification
defenses
contrasted
digestive
glands
each
mussel
population,
followed
assessment
vitro
wide
range
plastic
additives.
revealed
expressed
higher
enzymes,
although
sensitivity
targeted
populations.
Of
additives
tested,
CE
vivo
vitro.
screening
also
indicated
other
act
strong
inhibitors
CE.
However,
additional
are
needed
confirm
suitability
these
exposures.
All
together,
suggest
critical
population-level
differences
susceptibility
microplastic
pollution,
highlighting
need
conservation
efforts.
Environments,
Journal Year:
2025,
Volume and Issue:
12(1), P. 10 - 10
Published: Jan. 3, 2025
Microplastic
exposure
has
become
unavoidable,
leading
to
their
presence
in
living
organisms.
One
area
of
particular
concern
is
the
genotoxicity
microplastics,
which
implications
for
reproductive
health
and
cancer
development.
This
review
aims
highlight
genotoxic
effects
microplastics
on
different
organisms,
focusing
impacts
chromosomes,
DNA,
gene
expression.
More
than
85
papers,
primarily
published
last
five
years,
have
been
reviewed.
indicates
that
can
cause
clastogenesis
aneugenesis
at
chromosome
level.
Clastogenesis
results
damage,
while
leads
failures
segregation
without
causing
direct
damage.
Additionally,
fracture
damage
DNA.
These
arise
from
(1)
through
interactions
with
associated
proteins;
(2)
indirect
due
production
reactive
oxygen
species
(ROS)
by
oxidative
stress
induced
microplastics.
Microplastics
trigger
activation
genes
related
inflammatory
response,
increased
ROS
production.
Furthermore,
they
may
alter
expression
other
biological
processes.
The
linked
stem
particles
themselves
chemicals,
it
appears
be
both
size-
dose-dependent.
The Science of The Total Environment,
Journal Year:
2022,
Volume and Issue:
857, P. 159605 - 159605
Published: Oct. 20, 2022
The
growing
use
of
plastics,
including
microplastics
(MPs),
has
enhanced
their
potential
release
into
aquatic
environments,
where
microalgae
represent
the
basis
food
webs.
Due
to
physicochemical
properties,
MPs
may
act
as
carriers
organic
and
inorganic
pollutants.
present
study
aimed
determine
toxicity
polyethylene
(plain
oxidized)
model
pollutants
chlorpyrifos
(CPF)
mercury
(Hg)
on
red
Rhodomonas
lens,
contribute
understanding
effects
associated
marine
ecosystems,
role
vectors
potentially
harmful
R.
lens
cultures
were
exposed
(1-1000
μg/L;
25-24,750
particles/mL),
CPF
(1-4900
μg/L),
Hg
(1-500
CPF-
Hg-loaded
MPs,
for
96
h.
Average
specific
growth
rate
(ASGR,
day-1),
cellular
viability
pigment
concentration
(chlorophyll
a,
c2
carotenoids)
measured
at
48
No
significant
observed
pattern
after
96-h
exposure
plain
oxidized
MPs.
However,
a
increase
in
cell
was
detected
48-h
A
decrease
ASGR
noticed
CPF,
CPF/Hg-loaded
whereas
affected
by
Hg,
alone
combination.
Chlorophyll
significantly
decreased
when
while
both
pigments
increased
CPF-loaded
Similarly,
chlorophyll
carotenoids
content
higher
tested
concentration.
Overall,
presence
modulates
these
microalgae,
decreasing
toxic
probably
due
lower
bioavailability
contaminants.
Environmental Pollution,
Journal Year:
2023,
Volume and Issue:
320, P. 121053 - 121053
Published: Jan. 9, 2023
Microplastics
(MPs)
have
become
a
global
issue
as
they
are
omnipresent
in
the
ocean.
Fish
ingesting
MPs
through
feed
could
be
affected
their
physiological
function,
e.g.,
disrupted
enzyme
production
and
reduction
of
feeding
reproductive
failure.
This
study
assessed
effects
containing
naturally
weathered
from
Oslofjord
(Norway)
on
physiology
Atlantic
cod
(Gadus
morhua).
Farmed
broodstock
were
fed
either
control
(C-diet)
or
feeds
1%
microplastic
(MP-diet)
starting
nine
months
prior
to
spawning,
June
until
May.
No
major
differences
found
between
diet
groups
overall
biometrics
gonad
histology.
Sex
steroid
levels
(testosterone,
11-ketotestosterone
17β-estradiol)
resulted
expected
profiles
increasing
over
time
without
any
significant
treatments.
Gene
expression
steroidogenic
20β-hydroxysteroid
dehydrogenase
(20β-hsd)
vitellogenin1
(vtg1)
showed
dietary
treatments
with
lower
group.
can
direct
effect
MPs,
but
endocrine
disrupting
potentially
leachable
plastic
additives
cannot
completely
ruled
out.
Thus,
these
enzymes
indicators
exposure
contaminants
that
disrupt
sexual
maturation
by
affecting
primarily
maturation-inducing
steroid.
Although
concentration
employed
this
may
not
high
enough
elicit
observable
short-term
biological
effects,
observed
gene
suggests
long-term
consequences
should
considered
caused
an
increase
marine
environments.
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
468, P. 133819 - 133819
Published: Feb. 16, 2024
Biodegradable
polymers
have
been
proposed
as
an
alternative
to
conventional
plastics
mitigate
the
impact
of
marine
litter,
but
research
investigating
their
toxicity
is
still
in
its
infancy.
This
study
evaluates
potential
ecotoxicological
effects
both
virgin
and
marine-incubated
microparticles
(MPs),
at
environmentally
relevant
concentration
(0.1
mg/l),
made
different
biodegradable
(Polycaprolactone,
Mater-Bi,
cellulose)
(Polyethylene)
on
Mytilus
galloprovincialis
by
using
transcriptomics.
approach
increasingly
being
used
assess
pollutants
organisms,
obtaining
data
numerous
biological
pathways
simultaneously.
Whole
hepatopancreas
de
novo
transcriptome
sequencing
was
performed,
individuating
972
genes
differentially
expressed
across
experimental
groups
compared
control.
Through
comparative
transcriptomic
profiling
emerges
that
preponderant
effect
attributable
incubation
MPs,
especially
for
incubated
polycaprolactone
(731
DEGs).
Mater-Bi
cellulose
alter
smallest
number
processes
mussel
hepatopancreas.
All
microparticles,
regardless
polymeric
composition,
dysregulated
innate
immunity,
fatty
acid
metabolism
processes.
These
findings
highlight
necessity
considering
interactions
MPs
with
environmental
factors
ecosystem
when
performing
evaluations.
The
results
obtained
contribute
fill
current
knowledge
gaps
regarding
impacts
polymers.
Non-biodegradable
are
considered
hazardous
material
a
large
amount
scientific
publications
worldwide,
hazardousness
environment
open
question.
present
work
helps
understand
sentinel
species
comparing
entire
trascriptome
mussels
exposed
concentrations
natural
(cellulose),
Mater-Bi)
(polyethylene).
sea
make
experiment
extremely
realistic.
