Toxics,
Journal Year:
2025,
Volume and Issue:
13(3), P. 181 - 181
Published: Feb. 28, 2025
Mussels
serve
as
indicators
of
anthropogenic
chemical
pollution;
however,
the
effects
microplastics
and
plastic-related
chemicals
on
their
health
performance
remain
an
emerging
issue.
In
this
study,
mussels
were
exposed
to
a
polyamide
(PA;
5
μg/L)
tricresyl
phosphate
(TCP;
1
for
28
days.
The
exposures
two
contaminants
performed
independently
or
in
combination
lasted
results
showed
that
independent
exposure
altered
enzyme
activities
more
significantly
than
combined
one.
Exposure
PA
(p
<
0.05)
inhibited
antioxidant
catalase
(CAT)
by
43.5%
neurotransmitter
acetylcholinesterase
(AChE)
40.6%,
while
TCP
specifically
carboxylesterase
(CE)
activity
38.5%,
all
respect
solvent
control.
When
both
pollutants
combined,
most
biomarker
responses
similar
control
levels.
To
further
investigate
if
mussels’
response
(here,
compounds
only)
could
be
population-specific,
comparative
study
between
Atlantic
Mediterranean
was
included.
Firstly,
baseline
detoxification
defenses
contrasted
digestive
glands
each
mussel
population,
followed
assessment
vitro
wide
range
plastic
additives.
revealed
expressed
higher
enzymes,
although
sensitivity
targeted
populations.
Of
additives
tested,
CE
vivo
vitro.
screening
also
indicated
other
act
strong
inhibitors
CE.
However,
additional
are
needed
confirm
suitability
these
exposures.
All
together,
suggest
critical
population-level
differences
susceptibility
microplastic
pollution,
highlighting
need
conservation
efforts.
Aquaculture Research,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Investigating
the
impact
of
two
or
more
toxic
chemicals
on
aquatic
organisms
is
one
main
objectives
toxicological
research.
Microplastics
(MPs)
are
identified
as
a
carrier
vector
for
other
pollutants.
Therefore,
current
study
investigated
effects
both
pyrogallol
(PG)
and
MPs,
individually
in
combination,
freshwater
crayfish
(
Procambarus
clarkii
).
Following
15‐day
exposure
to
10
mg/L
PG
and100
MPs
their
combination
(10
+
100
MPs),
hemocyte
count,
hepatopancreatic
parameters,
antioxidant
variables,
histopathological
markers
were
all
assessed
crayfish.
The
results
revealed
that
potentially
combined
altered
count
(including
granular
semigranular)
compared
control
group
(0.001
≥
p
<
0.0001).
levels
aspartate
aminotransferase
(AST),
alanine
(ALT),
protein
showed
significant
elevation
0.05)
PG–MP‐exposed
fish
ones.
In
comparison
P.
,
measured
oxidation
indicators,
superoxide
dismutase
(SOD),
glutathione
(GSH),
total
capacity
(TAC),
reduction
after
single
>
0.0001),
while
catalase
(CAT)
malondialdehyde
(MDA)
elevated
drastically
(0.05
histology
hepatopancreas
has
shown
many
deformities
abnormalities
individual
toxicity,
such
vacuolations,
degraded
tubules,
eosinophilic
deposits,
hemocytic
infiltrations,
aberrant
tubules.
Accordingly,
there
synergistic
relationship
between
MP
toxicity
it
crucial
routinely
check
assess
discharge
waste
into
waterways.
Aquatic Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107369 - 107369
Published: April 1, 2025
Micro-
and
nanoplastic
particles
(MNPs)
are
pollutants
of
global
concern
due
to
their
persistence,
ubiquity,
associated
risks.
Laboratory
studies,
however,
have
predominantly
focused
on
pristine
MNPs,
which
do
not
adequately
reflect
the
characteristics
environmental
plastic
debris.
To
address
this
gap,
study
investigated
cellular
tissue-level
responses
mussels
(Mytilus
edulis)
aged
polyethylene
terephthalate
(PET)
MNPs
(diameter
600
nm
3.1
µm)
at
three
environmentally
relevant
concentrations:
10,
103,
105
particles/L.
The
particles'
physicochemical
stability
in
exposure
media
were
analyzed
using
a
combination
advanced
analytical
techniques.
biological
across
multiple
effect
endpoints
during
both
(days
1,
3,
7,
14)
subsequent
recovery
periods
(3
10
days
post-exposure),
via
flow
cytometry
histopathology.
results
revealed
sensitivity
hemocyte
subpopulations,
including
granulocytes
hyalinocytes,
PET
MNPs.
Concentration-
time-dependent
changes
lysosomal
stability,
oxidative
activity,
mortality
observed,
demonstrating
immediate
perturbations
potential
alleviate
particle-induced
effects.
Histopathological
analysis
key
tissues
exhibited
significant
alterations,
particularly
gill,
suggesting
impairment
essential
physiological
functions.
No
mussel
or
growth
metrics
observed
under
tested
experimental
conditions.
These
findings
underscore
systemic
impacts
MNP
highlight
importance
adopting
integrative,
realistic
approaches
assess
consequences
future
research.
Toxics,
Journal Year:
2025,
Volume and Issue:
13(3), P. 181 - 181
Published: Feb. 28, 2025
Mussels
serve
as
indicators
of
anthropogenic
chemical
pollution;
however,
the
effects
microplastics
and
plastic-related
chemicals
on
their
health
performance
remain
an
emerging
issue.
In
this
study,
mussels
were
exposed
to
a
polyamide
(PA;
5
μg/L)
tricresyl
phosphate
(TCP;
1
for
28
days.
The
exposures
two
contaminants
performed
independently
or
in
combination
lasted
results
showed
that
independent
exposure
altered
enzyme
activities
more
significantly
than
combined
one.
Exposure
PA
(p
<
0.05)
inhibited
antioxidant
catalase
(CAT)
by
43.5%
neurotransmitter
acetylcholinesterase
(AChE)
40.6%,
while
TCP
specifically
carboxylesterase
(CE)
activity
38.5%,
all
respect
solvent
control.
When
both
pollutants
combined,
most
biomarker
responses
similar
control
levels.
To
further
investigate
if
mussels’
response
(here,
compounds
only)
could
be
population-specific,
comparative
study
between
Atlantic
Mediterranean
was
included.
Firstly,
baseline
detoxification
defenses
contrasted
digestive
glands
each
mussel
population,
followed
assessment
vitro
wide
range
plastic
additives.
revealed
expressed
higher
enzymes,
although
sensitivity
targeted
populations.
Of
additives
tested,
CE
vivo
vitro.
screening
also
indicated
other
act
strong
inhibitors
CE.
However,
additional
are
needed
confirm
suitability
these
exposures.
All
together,
suggest
critical
population-level
differences
susceptibility
microplastic
pollution,
highlighting
need
conservation
efforts.
