Differential effects of foodborne and waterborne micro(nano)plastics exposure on fish liver metabolism and gut microbiota community

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137471 - 137471

Published: Feb. 2, 2025

Micro(nano)plastics (MNPs) primarily enter fish through two routes: directly ingestion via their diets and respiratory filtration gills. However, the specific impacts of these routes on liver metabolism remain largely unknown. Here, we investigated gene expression profiles Nile tilapia Oreochromis niloticus following equivalent doses foodborne waterborne MNPs exposure. While phenotypes O. showed minimal differences between exposure routes, significant variations were observed in response patterns. Using WGCNA, identified key networks KEGG pathways associated with each type. The primary transcription factors regulating changes thrb for fosl2 stimulus induced metabolic disorders circadian rhythm, whereas inflammatory responses to affect host metabolism. By integrating alterations gut microbiota enrichment data, further found that Firmicutes, Fusobacteriota, Proteobacteria, Chloroflexi jointly regulated mapk13 during exposure, most leading genes was predominantly influenced by Firmicutes. Collectively, our study demonstrated a distinct pattern microbiota-gene gut-liver axis

Language: Английский

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Metabolomics reveals the toxicity of polystyrene nanoplastics in the gills of Acrossocheilus yunnanensis

NanoImpact, Journal Year: 2025, Volume and Issue: unknown, P. 100552 - 100552

Published: Feb. 1, 2025

Language: Английский

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Effect of polystyrene nanoplastics on the intestinal histopathology, oxidative stress, and microbiota of Acrossocheilus yunnanensis

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107359 - 107359

Published: April 1, 2025

Language: Английский

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Toxic effects of emerging pollutants on mucosal organs of teleost fish: A review focusing on mucosal microbiota, physical barrier and immune barrier

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 978, P. 179431 - 179431

Published: April 16, 2025

Language: Английский

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Environmental behavior and toxic effects of micro(nano)plastics and engineered nanoparticles on marine organisms under ocean acidification: a review

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120267 - 120267

Published: Oct. 1, 2024

Language: Английский

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Physiological and immune profiling of tilapia Oreochromis niloticus gills by high-throughput single-cell transcriptome sequencing

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 141, P. 109070 - 109070

Published: Sept. 13, 2023

Language: Английский

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Occurrence and accumulation of microplastics in commercial fish in the coastal waters of the Lvsi fishing ground in China

Marine Pollution Bulletin, Journal Year: 2023, Volume and Issue: 194, P. 115181 - 115181

Published: Aug. 4, 2023

Language: Английский

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Conventional Anthelmintic Concentration of Deltamethrin Immersion Disorder in the Gill Immune Responses of Crucian Carp

Toxics, Journal Year: 2023, Volume and Issue: 11(9), P. 743 - 743

Published: Aug. 31, 2023

Current treatment strategies for parasitic infectious diseases in crucian carp primarily rely on chemotherapy. As a commonly used antiparasitic agent, deltamethrin (DEL) may have the potential adverse effects external mucosa of fish such as gills. In this study, 180 healthy juvenile (Carassius auratus) (average weight: 8.8 ± 1.0 g) were randomly divided into three groups 28 days, which immersed 0 μg/L, 0.3 and 0.6 μg/L DEL, respectively. The results histological analysis revealed that severe hyperplasia secondary lamellae gills was observed, number goblet (mucus-secreting) cells increased significantly after DEL immersion. TUNEL staining indicated apoptotic gill. At molecular level, mRNA expression significant upregulation apoptosis (caspase 3, caspase 8, bax), autophagy (atg5 beclin-1), immune response (lzm, muc5, il-6, il-8, il-10, tnfα, ifnγ, tgfβ, tlr4, myd88, nf-kb), whereas tight junction-related genes (occludin claudin12) downregulated immersion, suggesting immersion altered innate immunity responses promoted mucus secretion. Moreover, tandem mass tag (TMT)-based proteomics total 428 differentially expressed proteins (DEPs) contained 341 upregulated DEPs 87 with function annotation identified between control groups. Functional analyses enriched process, phagosome, lysosome pathways. Additionally, also drove gill microbiota to dysbiosis an increase potentially harmful bacteria Flavobacterium. Overall, study showed elicited shifts changes surface fish. These provide new perspectives conventional anthelmintic concentration disorder microenvironment theoretical support future optimization their practical application.

Language: Английский

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Contrasting the distribution kinetics of microplastics and nanoplastics in medaka following exposure and depuration

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135620 - 135620

Published: Aug. 23, 2024

Language: Английский

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Deltamethrin increased susceptibility to Aeromonas hydrophila in crucian carp through compromising gill barrier

Chemosphere, Journal Year: 2024, Volume and Issue: 365, P. 143379 - 143379

Published: Sept. 20, 2024

Language: Английский

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