Travel Medicine and Infectious Disease,
Journal Year:
2023,
Volume and Issue:
55, P. 102630 - 102630
Published: Aug. 9, 2023
Human
lice
have
always
been
a
major
public
health
concern
due
to
their
vector
capacity
for
louse-borne
infectious
diseases,
like
trench
fever,
relapsing
and
epidemic
which
are
caused
by
Bartonella
quintana,
Borrelia
recurrentis,
Rickettsia
prowazekii,
respectively.
Those
diseases
currently
re-emerging
in
the
regions
of
poor
hygiene,
social
poverty,
or
wars
with
life-threatening
consequences.
These
also
outbreaks
among
populations
jails
refugee
camps.
In
addition,
antibodies
DNAs
those
pathogens
steadily
detected
homeless
populations.
Importantly,
more
bacterial
human
lice,
some
transmitted
laboratories.
Here,
we
provide
comprehensive
review
update
on
diseases/bacterial
pathogens.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 4, 2024
The
dissemination
of
antibiotic
resistance
in
Escherichia
coli
poses
a
significant
threat
to
public
health
worldwide.
This
review
provides
comprehensive
update
on
the
diverse
mechanisms
employed
by
E.
developing
antibiotics.
We
primarily
focus
pathotypes
(e.g.,
uropathogenic
)
and
investigate
genetic
determinants
molecular
pathways
that
confer
resistance,
shedding
light
both
well-characterized
recently
discovered
mechanisms.
most
prevalent
mechanism
continues
be
acquisition
genes
through
horizontal
gene
transfer,
facilitated
mobile
elements
such
as
plasmids
transposons.
discuss
role
extended-spectrum
β
-lactamases
(ESBLs)
carbapenemases
conferring
-lactam
antibiotics,
which
remain
vital
clinical
practice.
covers
key
resistant
mechanisms,
including:
1)
Efflux
pumps
porin
mutations
mediate
broad
spectrum
including
fluoroquinolones
aminoglycosides;
2)
adaptive
strategies
,
biofilm
formation,
persister
cell
activation
stress
response
systems,
withstand
pressure;
3)
regulatory
systems
coordinating
providing
insights
into
potential
targets
for
therapeutic
interventions.
Understanding
intricate
network
is
crucial
development
effective
combat
this
growing
crisis.
By
clarifying
these
we
aim
pave
way
design
innovative
approaches
implementation
prudent
stewardship
practices
preserve
efficacy
current
antibiotics
ensure
sustainable
future
healthcare.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 27, 2024
Abstract
Previous
studies
reported
microplastics
(MPs),
antibiotics,
and
antibiotic
resistance
genes
(ARGs)
in
wastewater
treatment
plants
(WWTPs).
There
is
still
a
lack
of
research
progress
on
the
origin,
fate,
impact
hazards
MPs
ARGs
WWTPs.
This
paper
fills
gap
this
regard.
In
our
search,
we
used
“microplastics”,
“antibiotic
genes”,
“wastewater
plant”
as
topic
terms
Web
Science,
checking
returned
results
for
relevance
by
examining
titles
abstracts.
study
mainly
explores
following
points:
(1)
origins
fate
MPs,
antibiotics
WWTPs;
(2)
mechanisms
action
sludge
biochemical
pools;
(3)
impacts
WWTPs
spread
ARGs;
(4)
harm
inflicted
environment
human
body.
Contaminants
sewage
such
ARGs,
antibiotic-resistant
bacteria
enter
soil
water.
can
travel
through
food
chain
thus
reach
humans,
leading
to
increased
illness,
hospitalization,
even
mortality.
will
enhance
understanding
among
they
inflict
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 6814 - 6814
Published: June 21, 2024
represents
a
significant
concern
in
nosocomial
settings,
particularly
critically
ill
patients
who
are
forced
to
remain
hospital
for
extended
periods.
The
challenge
of
managing
and
preventing
this
organism
is
further
compounded
by
its
increasing
ability
develop
resistance
due
extraordinary
genomic
plasticity,
response
adverse
environmental
conditions.
Its
recognition
as
public
health
risk
has
provided
impetus
the
identification
new
therapeutic
approaches
infection
control
strategies.
Indeed,
currently
used
antimicrobial
agents
gradually
losing
their
efficacy,
neutralized
newer
mechanisms
bacterial
resistance,
especially
carbapenem
antibiotics.
A
deep
understanding
underlying
molecular
urgently
needed
shed
light
on
properties
that
allow
Aquaculture International,
Journal Year:
2024,
Volume and Issue:
32(7), P. 9017 - 9078
Published: July 17, 2024
Abstract
The
aquaculture
industry
is
suffering
from
significant
financial
setbacks
due
to
an
increasing
frequency
of
disease
outbreaks,
posing
a
threat
the
sector’s
sustainability.
Various
bacterial,
viral,
parasitic,
and
fungal
pathogens
have
led
massive
mortalities
in
farmed
fish
worldwide.
Throughout
years,
management
diseases
has
predominantly
centered
around
utilization
conventional
antibiotics
chemicals.
Nevertheless,
their
indiscriminate
use
given
rise
serious
implications,
including
increase
resistant
pathogens,
disruptions
metabolic
processes
fish,
degradation
aquatic
environment,
presence
drug
residues
products,
potential
human
health.
effective
bio-based
immunoprophylaxis
alternative
therapies
been
developed
overcome
these
impediments.
Recent
therapeutic
approaches
encompass
range
strategies,
phytotherapeutics,
nanotherapeutics,
probiotics,
prebiotics,
synbiotics,
phage
therapy,
vaccination,
quorum
quenching,
antimicrobial
peptides,
biosurfactants,
bacteriocins,
stem
cells,
diagnostic-based
therapy.
Advancements
biotechnology
significantly
enhanced
efficacy
therapies.
However,
additional
research
essential
refine
approaches.
Critical
concerns,
such
as
efficacy,
cost,
risks,
availability,
adverse
effects
on
ecosystem,
need
be
addressed
establish
guidelines
for
sustainable
application
aquaculture.
This
review
will
aquaculturists’
awareness
recent
used
farming,
mechanisms,
challenges,
impacts
while
promoting
sustainability
commercial
Journal of Global Antimicrobial Resistance,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Carbapenem-resistant
Acinetobacter
baumannii
(CRAB),
particularly
the
globally
prevalent
ST2
clone,
poses
significant
threats
in
Gulf
Cooperation
Council
region
through
extensive
drug
resistance,
high
virulence,
and
efficient
gene
transfer.
This
study
investigates
epidemiological
genomic
characteristics
of
CRAB
Jazan
region,
using
whole
genome
sequencing
to
understand
its
transmission
genetic
determinants.
Sixty-five
clinical
A.
isolates
exhibiting
phenotypic
resistance
carbapenems
(meropenem,
imipenem,
ertapenem)
were
collected
from
various
tertiary
hospitals
region.
The
presence
carbapenemase
genes
among
these
was
examined
two
sets
multiplex
polymerase
chain
reaction
(PCR).
Forty-eight
confirmed
as
producers
selected
for
WGS
analysis.
Among
65
isolates,
adult
ICU
exhibited
highest
prevalence
(76.9%).
Multiplex
PCR
identified
48
(73.8%)
producers,
all
harboring
blaOXA-51-like
genes.
Specifically,
blaOXA-23
detected
39
(60%),
blaNDM
8
(12.3%),
blaOXA-24
one
isolate.
These
carbapenemase-producing
also
carried
virulence-associated
related
adherence,
biofilm
formation,
immune
evasion,
iron
acquisition
regulation,
serum
resistance.
Whole-genome
(WGS)
revealed
that
(81.2%)
carbapenemase-positive
belonged
ST2,
followed
by
ST85
ST107,
with
KL152
locus
most
common
capsule
type.
indicates
a
rise
clone
Arabian
Gulf,
Saudi
Arabia,
underscores
need
ongoing
surveillance
less
clones
such
ST107
manage
public
health
risks
effectively.
Environment International,
Journal Year:
2024,
Volume and Issue:
190, P. 108831 - 108831
Published: June 18, 2024
Antibiotic
resistance
in
soil
introduced
by
organic
fertilizer
application
pose
a
globally
recognized
threat
to
human
health.
Insect
may
be
promising
alternative
due
its
low
antibiotic
resistance.
However,
it
is
not
yet
clear
how
regulate
microbes
reduce
agricultural
application.
In
this
study,
we
investigated
and
resistome
under
black
soldier
fly
(BOF)
pot
field
systems.
Our
study
shows
that
BOF
could
stimulate
ARB
(antibiotic
resistant
−
bacteria)
suppressive
Bacillaceae
the
microbiome
resistome.
The
carbohydrate
transport
metabolism
pathway
of
was
strengthened,
which
accelerated
synthesis
polysaccharides
form
biofilm
antagonistic
ARB,
thus
reduced
We
further
tested
Bacillus
spp.
microcosm
assay,
resulted
significant
decrease
presence
ARGs
together
with
higher
abundance
key
formation
gene
(epsA).
This
knowledge
might
help
development
more
efficient
bio-fertilizers
aimed
at
mitigating
enhancing
health,
particular,
requirements
global
"One
Health".
Biotechnology and Bioengineering,
Journal Year:
2023,
Volume and Issue:
121(1), P. 82 - 99
Published: Oct. 26, 2023
Defending
against
antibiotic-resistant
infections
is
similar
to
fighting
a
war
with
limited
ammunition.
As
the
new
century
unfolded,
antibiotic
resistance
became
significant
concern.
In
spite
of
fact
that
phage
treatment
has
been
used
as
an
effective
means
for
more
than
century,
researchers
have
had
overcome
many
challenges
superbug
bacteria
by
manipulating
phages
and
producing
engineered
enzymes.
New
enzymes
enhanced
properties
impact
on
ability
fight
infections,
which
considered
window
hope
future.
This
review,
therefore,
illustrates
not
only
caused
but
also
are
being
developed
solve
these
issues.
Our
study
found
phages,
proteins,
can
be
in
treating
destroying
biofilm
them.
Combining
compounds
other
antimicrobial
substances
increase
their
effectiveness
bacteria.
Therefore,
substitute
antibiotics
or
combination
treat
patients
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1251 - 1251
Published: April 15, 2023
Carbapenem-resistant
Acinetobacter
baumannii
(CRAB)
is
the
most
detrimental
pathogen
that
causes
hospital-acquired
infections.
Tigecycline
(TIG)
currently
used
as
a
potent
antibiotic
for
treating
CRAB
infections;
however,
its
overuse
substantially
induces
development
of
resistant
isolates.
Some
molecular
aspects
resistance
mechanisms
AB
to
TIG
have
been
reported,
but
they
are
expected
be
far
more
complicated
and
diverse
than
what
has
characterized
thus
far.
In
this
study,
we
identified
bacterial
extracellular
vesicles
(EVs),
which
nano-sized
lipid-bilayered
spherical
structures,
mediators
resistance.
Using
laboratory-made
TIG-resistant
(TIG-R
AB),
demonstrated
TIG-R
produced
EVs
control
TIG-susceptible
(TIG-S
AB).
Transfer
analysis
AB-derived
treated
with
proteinase
or
DNase
recipient
TIG-S
showed
EV
proteins
major
factors
in
transfer.
Additional
transfer
spectrum
EV-mediated
was
selectively
transferred
Escherichia
coli,
Salmonella
typhimurium,
Proteus
mirabilis.
However,
action
not
observed
Klebsiella
pneumonia
Staphylococcus
aureus.
Finally,
likely
induce
antibiotics.
Our
data
provide
direct
evidence
cell-derived
components
high,
selective
occurrence
neighboring
cells.