Research progress on metal pollutants inducing neurotoxicity through ferroptosis DOI
Zhiqiang Qin, Yuqing Chen, Xinyuan Zhao

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

It has been confirmed that exposure to various metal pollutants can induce neurotoxicity, which is closely associated with the occurrence and development of neurological disorders. Ferroptosis a form cell death in response pollutant it related oxidative stress, iron metabolism lipid peroxidation. Recent studies have revealed ferroptosis plays significant role neurotoxicity induced by metals such as lead, cadmium, manganese, nickel, antimony. Lead triggers through disorder inflammation. Cadmium ion metabolism, stress signaling pathways IRE1/JNK/FTH1. Manganese promote mitochondrial dysfunction, stress. Nickel influencing function, disrupting homeostasis facilitating peroxidation central nervous system. Antimony glutathione depletion activating autophagy, resulting excessive intracellular deposition ultimately causing ferroptosis. This article reviews effects on ferroptosis-related indicators discusses specific mechanisms each may provide references identify targets preventing develop treatment strategies

Language: Английский

Research progress on metal pollutants inducing neurotoxicity through ferroptosis DOI
Zhiqiang Qin, Yuqing Chen, Xinyuan Zhao

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

It has been confirmed that exposure to various metal pollutants can induce neurotoxicity, which is closely associated with the occurrence and development of neurological disorders. Ferroptosis a form cell death in response pollutant it related oxidative stress, iron metabolism lipid peroxidation. Recent studies have revealed ferroptosis plays significant role neurotoxicity induced by metals such as lead, cadmium, manganese, nickel, antimony. Lead triggers through disorder inflammation. Cadmium ion metabolism, stress signaling pathways IRE1/JNK/FTH1. Manganese promote mitochondrial dysfunction, stress. Nickel influencing function, disrupting homeostasis facilitating peroxidation central nervous system. Antimony glutathione depletion activating autophagy, resulting excessive intracellular deposition ultimately causing ferroptosis. This article reviews effects on ferroptosis-related indicators discusses specific mechanisms each may provide references identify targets preventing develop treatment strategies

Language: Английский

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