Journal of King Saud University - Science,
Journal Year:
2023,
Volume and Issue:
35(7), P. 102821 - 102821
Published: Aug. 6, 2023
Antiepileptic
drugs
(ADEs)
are
now
used
to
treat
a
wide
range
of
neurological
problems,
although
their
usage
is
still
restricted
due
side
effects,
particularly
hepatotoxicity.
Thus,
this
study
consists
the
therapeutic
effects
non-
conditioned
Mesenchymal
Stem
Cells
(MSCs)
and
MSCs
preconditioned
with
cherry
extract
(MSCs
CM)
on
mitigation
liver
damage
induced
by
dual
administration
antiepileptic
such
as
Levetiracetam
(L)
Oxcarbazepine
(O).
The
toxicity
was
in
male
albino
rats
means
ADEs
examined
help
different
paraments
biochemical
(total
protein,
albumin,
globulin
levels,
A/G
ratio
level
ALT,
GGTP),
Oxidative
stress
(MDA,
NO,
GSH),
western
blotting
assay,
immune-histopathology,
histopathological
examinations.
results
revealed
that
treated
LO
showed
an
increase
GGTP,
MDA,
Bax,
protein
expression
AKT
BI3K,
caspase
3
along
decrease
GSH,
total
albumin
levels
well
as,
Bcl2.
or
MSC
CM
treatment
post
drug
ameliorate
these
parameters.
Our
findings
suggest
could
be
disparity
purpose
towards
normal.
it
may
deduced
can
hepatoprotection
against
ADEs-mediated
hepatotoxicity
hence
signifying
they
valuable
natural
remedy
for
treating
caused
drugs.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(8), P. e18426 - e18426
Published: July 19, 2023
The
Pharmaceuticals
and
Personal
Care
Products
(PPCPs)
presence
at
harmful
levels
has
been
identified
in
aquatic
ecosystems
all
over
the
world.
Currently,
PPCPs
are
more
common
regions
have
discovered
to
be
extremely
creatures.
Waste-water
treatment
facilities
primary
cause
of
pollution
systems
due
their
limited
as
well
following
release
PPCPs.
degree
elimination
is
primarily
determined
by
method
applied
for
remediation.
It
must
addressed
an
eco-friendly
manner
order
significantly
improve
environmental
quality
or,
very
least,
prevent
spread
effects
toxic
pollutants.
However,
when
compared
other
methods,
environmentally
friendly
strategies
(biological
methods)
less
expensive
require
energy.
Most
biological
methods
under
aerobic
conditions
shown
degrade
effectively.
Furthermore,
scientific
literature
indicates
that
with
exception
a
few
hydrophobic
substances,
degradation
microbes
process
majority
compounds.
Hence,
this
review
discusses
about
optimistic
role
microbe
concerned
or
transformation
into
non/less
form
polluted
environment.
Accordingly,
number
microbial
strains
implicated
biodegradation/transformation
through
termed
bioremediation
limitations.
Chemosphere,
Journal Year:
2024,
Volume and Issue:
364, P. 143214 - 143214
Published: Aug. 29, 2024
Anthropogenic
activities
have
led
to
increased
levels
of
contaminants
that
pose
significant
threats
aquatic
organisms,
particularly
fishes.
One
such
contaminant
is
Selenium
(Se),
a
metalloid
which
released
by
various
industrial
including
mining
and
fossil
fuel
combustion.
crucial
for
physiological
functions,
however
it
can
bioaccumulate
become
toxic
at
elevated
concentrations.
Given
fishes
are
key
predators
in
ecosystems
major
protein
source
humans,
Se
accumulation
raises
considerable
ecological
food
safety
concerns.
induces
toxicity
the
cellular
level
disrupting
balance
between
reactive
oxygen
species
(ROS)
production
antioxidant
capacity
leading
oxidative
damage.
Chronic
exposure
impairs
wide
range
critical
functions
metabolism,
growth
reproduction.
also
potent
teratogen
types
adverse
developmental
effects
fishes,
mainly
due
its
maternal
transfer
eggs.
Moreover,
persist
across
generations.
Furthermore,
Se-induced
stress
brain
driver
neurotoxicity,
leads
impairment
several
ecologically
important
behaviours
cognition
memory
social
preference
interactions,
anxiety
response.
Our
review
provides
an
up-to-date
in-depth
analysis
while
identifying
knowledge
gaps
need
be
addressed
future
research
greater
insights
into
impact
ecosystems.
IWA Publishing eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 12, 2024
Abstract
Detection
and
Treatment
of
Emerging
Contaminants
in
Wastewater
addresses
the
critical
pressing
need
for
effective
strategies
to
detect
treat
emerging
contaminants,
thereby
mitigating
risks
associated
with
their
presence
wastewater.
This
comprehensive
book
features
contributions
from
prominent
experts
field
wastewater,
providing
an
up-to-date
in-depth
collection
chapters
dedicated
tackling
this
issue.
Highlights:
The
serves
as
invaluable
resource
identifying,
assessing,
comprehensively
addressing
contaminants
wastewater
and/or
sludges.
It
delves
into
assessment,
mitigation,
treatment
various
including
microplastics,
antibiotic-resistant
genes,
pharmaceuticals,
personal
care
products
industrial
chemicals.An
exploration
behavior
microplastics
different
plants
accumulation
sludge,
shedding
light
on
potential
impact
environment.An
introduction
key
mechanisms
removal
pollutants
sludge
through
fungal-mediated
processes,
offering
innovative
solutions
treatment.An
investigation
fate
pharmaceutically-active
compounds
along
environmental
impacts.
Additionally,
accurate
quantification
procedures
these
are
discussed.The
covers
new
trends
development
greener
nanomaterials,
evaluating
performance
abating
With
its
insights
diverse
perspectives,
is
essential
guide
researchers,
professionals,
policymakers
engaged
management
protection.
practical
scientific
knowledge
presented
herein
will
contribute
significantly
safeguarding
our
water
resources
ensuring
a
cleaner
healthier
future.
ISBN:
9781789063745
(paperback)
9781789063752
(ebook)
(ePub)
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0312694 - e0312694
Published: Jan. 8, 2025
Understanding
the
mechanisms
that
underlie
adaptive
response
of
ectotherms
to
rising
temperatures
is
key
mitigate
effects
climate
change.
We
assessed
molecular
and
physiological
processes
differentiate
between
rainbow
trout
(
Oncorhynchus
mykiss
)
with
high
low
tolerance
acute
thermal
stress.
To
achieve
our
goal,
we
used
a
critical
maximum
trial
in
two
strains
elicit
loss
equilibrium
responses
identify
fish.
then
compared
hepatic
transcriptome
profiles
fish
relative
untreated
controls
common
both
uncover
patterns
differential
gene
expression
gain
broad
perspective
on
interacting
pathways
functional
involved.
observed
some
classic
increased
temperature
(e.g.,
induction
heat
shock
proteins)
but
these
were
not
defining
factors
differentiated
Instead,
appeared
suppress
growth-related
functions,
enhance
certain
autophagy
components,
better
regulate
neurodegenerative
processes,
stress-related
protein
synthesis,
specifically
spliceosomal
complex
activities,
mRNA
regulation,
processing
through
post-translational
In
contrast,
had
higher
transcript
diversity
demonstrated
elevated
developmental,
cytoskeletal,
morphogenic,
as
well
lipid
carbohydrate
metabolic
Our
results
suggest
engaged
supported
prevention
further
damage
by
enhancing
repair
pathways,
whereas
more
focused
replacing
damaged
cells
their
structures.
Veterinární Medicína,
Journal Year:
2025,
Volume and Issue:
70(1), P. 20 - 29
Published: Jan. 20, 2025
The
present
study
aimed
to
evaluate
the
biochemical
and
antioxidant
responses
of
common
carp
after
exposure
antiepileptic
analgesic
drug
gabapentin
at
concentrations
0.1,
1,
10,
100
μg/l
for
4
weeks.
highest
two
resulted
in
significant
changes
plasma
indices
such
as
glucose
(only
group
μg/l),
alanine
aminotransferase
(ALT),
lactate
dehydrogenase
(LDH),
lipase,
creatine
kinase
(CK),
amylase
well
butyrylcholinesterase
(BChE).
Similar
trends
were
found
both
groups
exposed
environmentally
relevant
(i.e.,
0.1
1
μg/l).
In
addition,
a
increase
ferric-reducing
power
was
noted
all
treated
groups.
Numerous
enzymes,
superoxide
dismutase,
catalase,
glutathione-S-transferase,
lipid
peroxidation,
observed
especially
caudal
kidney
μg/l.
Significant
findings
also
confirmed
an
concentration
(1
with
decrease
dismutase
gill
increased
lipoperoxidation
kidney.
Our
research
shows
that
subchronic
may
pose
risk
non-target
aquatic
organisms,
disruption
metabolic
pathways
or
induction
oxidative
stress,
even
concentrations.
