The
increasing
number
of
deaths
caused
by
mosquito-borne
diseases
highlights
the
need
to
produce
efficient
and
environmentally
sustainable
alternatives.
aim
present
investigation
we
have
utilized
leaf
from
Laureliopsis
philippiana
(LP)
synthesize
silver
(Ag)
palladium
(Pd)
nanoparticles
(NPs)
studied
toxicity
on
deadly
disease
vectors
larvae
Aedes
aegypti
Anopheles
stephensi.
Biosynthesized
Ag
Pd
NPs
were
investigated
UV-Vis
spectroscopy,
Fourier
transform
infrared
(FT-IR),
X-Ray
Diffraction
(XRD),
Transmission
electron
microscopy
(TEM),
Zeta
potential
analysis.
GC-MS
analysis
L.
assisted
in
identifying
secondary
metabolites
extract's
total
flavonoid
phenolic
compounds,
which
are
reactants
bio-reduction
process
during
production
nanoparticles.
in-silico
was
conducted
mosquito
sterol
carrier
protein-2
(1PZ4)
odorant
binding
protein
(2L2C).
XRD
results
revealed
crystalline
structure
NPs.
At
same
time,
TEM
representation,
biosynthesized
spherical,
clustered,
exhibited
a
noticeable
UV
peak
at
417
370
nm
(average
size
AgNPs:
13.25±
2.53
PdNPs:
4.07±
1.64
nm).
biogenic
concentration-dependent
larvicidal
effect
with
LC50
values
29.596,
17.804,
23.915,
14.878
µg/mL
Ae.
23.946,
13.938,
19.457,
12.876
against
An.
stephensi,
correspondingly.
In-silico
studies
proved
that
Laureliopsine
A
(-7.6
-8.4
kcal/mol)
isoterpinolene
(-7.0
-6.7
showed
significant
docking
scores
comparison
permethrin
(-5.3
-8.0
kcal/mol),
proteins
(1PZ4
2L2C).
Besides,
LP-Ag
non-toxicity
carried
out
Zebrafish
embryos
72h
post-fertilization.
Overall,
findings
clearly
demonstrated
green
synthesized
develop
secure
safe
larvicides.
Bioinorganic Chemistry and Applications,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 13
Published: May 11, 2023
Insects
act
as
vectors
to
carry
a
wide
range
of
bacteria
and
viruses
that
can
cause
multiple
vector-borne
diseases
in
humans.
Diseases
such
dengue
fever,
epidemic
encephalitis
B,
typhus,
which
pose
serious
risks
humans,
be
transmitted
by
insects.
Due
the
absence
effective
vaccines
for
most
arbovirus,
insect
control
was
main
strategy
control.
However,
rise
drug
resistance
brings
great
challenge
prevention
diseases.
Therefore,
finding
an
eco-friendly
method
vector
is
essential
combat
Nanomaterials
with
ability
resist
insects
deliver
drugs
offer
new
opportunities
increase
agent
efficacy
compared
traditional
agents,
application
nanoagents
has
expanded
field
disease
Up
now,
reviews
nanomaterials
mainly
focus
on
biomedicines,
insect-borne
always
been
neglected
field.
In
this
study,
we
analyzed
425
works
literature
about
different
nanoparticles
applied
PubMed
around
keywords,
as“nanoparticles
against
insect,”
“NPs
“metal
insect.”
Through
these
articles,
development
(NPs)
control,
discussing
lethal
mechanism
NPs
vectors,
explore
prospect
applying
nanotechnology
vectors.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(8), P. 2285 - 2285
Published: Aug. 17, 2023
The
utilization
of
nanoparticles
derived
from
algae
has
generated
increasing
attention
owing
to
their
environmentally
sustainable
characteristics
and
capacity
interact
harmoniously
with
biologically
active
metabolites.
present
study
utilized
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(2), P. 325 - 325
Published: Feb. 2, 2025
In
the
scenario
of
fighting
bacterial
resistance
to
antibiotics,
natural
products
have
been
extensively
investigated
for
their
potential
antibacterial
activities.
Among
these,
cannabinoids—bioactive
compounds
derived
from
cannabis—have
garnered
attention
diverse
biological
activities,
including
anxiolytic,
anti-inflammatory,
analgesic,
antioxidant,
and
neuroprotective
properties.
Emerging
evidence
suggests
that
cannabinoids
may
also
possess
significant
antimicrobial
properties,
with
applications
in
enhancing
efficacy
conventional
agents.
Therefore,
this
review
examines
past
five
years
on
properties
cannabinoids,
focusing
underlying
mechanisms
such
as
microbial
membrane
disruption,
immune
response
modulation,
interference
virulence
factors.
addition,
synergistic
potential,
when
used
alongside
standard
therapies,
underscores
promise
a
novel
strategy
address
drug
resistance,
although
further
research
clinical
trials
are
needed
validate
therapeutic
use.
Overall,
offer
promising
avenue
development
innovative
treatments
combat
drug-resistant
infections
reduce
reliance
traditional
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101408 - 101408
Published: Jan. 1, 2024
In
order
to
eradicate
mosquito-borne
diseases
like
malaria,
chikungunya,
dengue,
and
Zika
virus
which
are
mostly
found
in
temperate
zones,
synthetic
pesticides
widely
used
as
a
form
of
fumigation.
This
has
resulted
rise
disease
transmission
dynamics
substantial
atmospheric
pollution.
light
this,
the
current
work
an
aqueous
extract
Phaseolus
vulgaris
formulate
bioencapsulated
CuO
ZnO
NPs
combat
mosquito
vectors.
The
synthesized
were
characterized
using
UV–visible,
XRD,
FT-IR,
FE-SEM
&
EDX,
AFM,
DLS
techniques.
According
analytical
characterization,
had
monoclinic
hexagonal
crystallites
with
average
sizes
13.7
nm
185
nm,
respectively.
analysis
confirms
spherical
flower-like
morphology
their
respective
elemental
composition
was
identified
by
EDX
studies.
particle
size
determined
be
22.6
662
nm.
possessed
zeta
potential
values
−23.2
mV
−29.7
larvae
malaria
vector
Anopheles
stephensi
dengue
Aedes
aegypti
subjected
compare
larvicidal
bioassays
range
concentrations
P.
methanol
extracts,
(6.25,
12.5,
25,
50,
100
µg/mL).
results
showed
activity
is
superior
NPs.
study
further
revealed
that
vulnerable
than
given
concentration
crude
aqueous,
extracts
overall
findings
this
research
demonstrated
feasibility
these
biosynthesized
nanoparticles
highly
effective,
eco-friendly
natural
control
pesticides.
