Applied Organometallic Chemistry,
Journal Year:
2023,
Volume and Issue:
38(1)
Published: Nov. 7, 2023
Diabetes
mellitus
(DM)
is
one
of
the
most
prevalent,
fatal,
and
non‐contagious
diseases.
Therefore,
researchers
are
making
attempts
to
develop
novel
anti‐diabetic
drugs
using
various
organic
compounds
biomolecules.
The
idea
nano‐materials
as
agents
seems
interesting.
current
study
aims
Kickxia
elatine
(KE)
extract‐based
nano‐silver
(KE‐AgNPs)
evaluate
their
in
vivo
potency
female
Sprague
Dawley
rats.
KE‐AgNPs
were
characterized
UV
spectroscopy,
X‐ray
diffractometer
(XRD),
scanning
electron
microscopy
(SEM),
Electron
Diffraction
Spectroscopy
(EDX),
Fourier
transforms
infrared
(FTIR)
techniques.
crystalline
nature
with
a
size
42.47
nm
confirmed
by
XRD
screening.
Spherical‐shaped
mono‐dispersed
mean
50
validated
SEM
examination.
different
phyto‐compounds
(tannins,
alkaloids,
flavonoids,
proteins,
saponins,
phenols,
carbohydrates,
quinones,
sterols,
fats,
oils)
that
contribute
stabilization
reduction
FTIR
analysis.
EDX
showed
strong
peak
(3.2
keV)
identified
Ag
main
component
61.67%
contribution.
use
Alloxan
induce
diabetes
resulted
elevated
levels
blood
sugar,
HbA1c,
liver,
lipid
profile,
well
drastic
body
weight,
organ
Hemoglobin.
These
modifications
switched
following
21
days
treatment
diabetic
rats,
dosage
range
150–450
mg
kg
−1
BW
KE
extract
demonstrated
significant
inhibition
compared
untreated
group.
phytochemical
analysis
plant
was
also
assessed
examine
involved
potential
KE‐AgNPs.
findings
suggested
that,
comparison
extract,
have
promising
action.
The
increasing
number
of
deaths
caused
by
mosquito-borne
diseases
highlights
the
need
to
produce
efficient
and
environmentally
sustainable
alternatives.
aim
present
investigation
we
have
utilized
leaf
from
Laureliopsis
philippiana
(LP)
synthesize
silver
(Ag)
palladium
(Pd)
nanoparticles
(NPs)
studied
toxicity
on
deadly
disease
vectors
larvae
Aedes
aegypti
Anopheles
stephensi.
Biosynthesized
Ag
Pd
NPs
were
investigated
UV-Vis
spectroscopy,
Fourier
transform
infrared
(FT-IR),
X-Ray
Diffraction
(XRD),
Transmission
electron
microscopy
(TEM),
Zeta
potential
analysis.
GC-MS
analysis
L.
assisted
in
identifying
secondary
metabolites
extract's
total
flavonoid
phenolic
compounds,
which
are
reactants
bio-reduction
process
during
production
nanoparticles.
in-silico
was
conducted
mosquito
sterol
carrier
protein-2
(1PZ4)
odorant
binding
protein
(2L2C).
XRD
results
revealed
crystalline
structure
NPs.
At
same
time,
TEM
representation,
biosynthesized
spherical,
clustered,
exhibited
a
noticeable
UV
peak
at
417
370
nm
(average
size
AgNPs:
13.25±
2.53
PdNPs:
4.07±
1.64
nm).
biogenic
concentration-dependent
larvicidal
effect
with
LC50
values
29.596,
17.804,
23.915,
14.878
µg/mL
Ae.
23.946,
13.938,
19.457,
12.876
against
An.
stephensi,
correspondingly.
In-silico
studies
proved
that
Laureliopsine
A
(-7.6
-8.4
kcal/mol)
isoterpinolene
(-7.0
-6.7
showed
significant
docking
scores
comparison
permethrin
(-5.3
-8.0
kcal/mol),
proteins
(1PZ4
2L2C).
Besides,
LP-Ag
non-toxicity
carried
out
Zebrafish
embryos
72h
post-fertilization.
Overall,
findings
clearly
demonstrated
green
synthesized
develop
secure
safe
larvicides.
Applied Organometallic Chemistry,
Journal Year:
2023,
Volume and Issue:
38(1)
Published: Nov. 7, 2023
Diabetes
mellitus
(DM)
is
one
of
the
most
prevalent,
fatal,
and
non‐contagious
diseases.
Therefore,
researchers
are
making
attempts
to
develop
novel
anti‐diabetic
drugs
using
various
organic
compounds
biomolecules.
The
idea
nano‐materials
as
agents
seems
interesting.
current
study
aims
Kickxia
elatine
(KE)
extract‐based
nano‐silver
(KE‐AgNPs)
evaluate
their
in
vivo
potency
female
Sprague
Dawley
rats.
KE‐AgNPs
were
characterized
UV
spectroscopy,
X‐ray
diffractometer
(XRD),
scanning
electron
microscopy
(SEM),
Electron
Diffraction
Spectroscopy
(EDX),
Fourier
transforms
infrared
(FTIR)
techniques.
crystalline
nature
with
a
size
42.47
nm
confirmed
by
XRD
screening.
Spherical‐shaped
mono‐dispersed
mean
50
validated
SEM
examination.
different
phyto‐compounds
(tannins,
alkaloids,
flavonoids,
proteins,
saponins,
phenols,
carbohydrates,
quinones,
sterols,
fats,
oils)
that
contribute
stabilization
reduction
FTIR
analysis.
EDX
showed
strong
peak
(3.2
keV)
identified
Ag
main
component
61.67%
contribution.
use
Alloxan
induce
diabetes
resulted
elevated
levels
blood
sugar,
HbA1c,
liver,
lipid
profile,
well
drastic
body
weight,
organ
Hemoglobin.
These
modifications
switched
following
21
days
treatment
diabetic
rats,
dosage
range
150–450
mg
kg
−1
BW
KE
extract
demonstrated
significant
inhibition
compared
untreated
group.
phytochemical
analysis
plant
was
also
assessed
examine
involved
potential
KE‐AgNPs.
findings
suggested
that,
comparison
extract,
have
promising
action.