DEHP
is
a
plasticizer
that
can
damage
various
organizations
and
physiques
through
oxidative
stress.
Quercetin
rich
polyphenol
flavonoid
with
good
anti-inflammatory
antioxidant
effects.
However,
the
protection
mechanism
of
Que
against
exposure-induced
IPEC-J2
cell
injury
implication
autophagy,
apoptosis
immunity
are
still
unclear.
In
this
experiment,
we
looked
into
toxicity
regime
exposure
on
cells
antagonistic
function
DEHP.
135
μM
and/or
80
were
used
to
treat
for
24
hours.
Experiments
indicated
cause
increased
reactive
oxygen
species
(ROS)
levels
leading
stress,
decreased
CAT,
T-AOC
GSH-Px
activities,
MDA
H2O2
accumulation,
activated
ASK1/JNK
signalling
pathway,
further
increases
in
markers
Bax,
Caspase
3,
9,
Cyt-c,
while
reduced
Bcl-2
expression.
also
expression
genes
linked
autophagy
(ATG5,
Beclin1,
LC3),
decreasingd
P62.
Additionally,
led
elevated
IL1-β,
IL-6,
MCP-1,
TNF
When
exposed
alone,
there
no
significant
changes
cellular
stress
level,
pathway
apoptosis,
immune
function.
The
combination
treatment
remarkably
proportion
recovered
immunity.
summary,
attenuate
DEHP-induced
by
regulating
ROS/ASK1/JNK
improving
dysfunction
cells.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 2, 2025
Bis(2-ethylhexyl)
phthalate
(DEHP)
is
an
endocrine
disruptor
that
may
cause
damage
to
several
species.
Quercetin
(Que),
a
common
flavonoid,
has
anti-inflammation,
antioxidation,
and
immune
regulation
properties.
In
this
study,
we
identified
DEHP-exposed
or
Que-antagonist
groups
in
chicken
MSB-1
cells
explore
whether
Que
can
mitigate
DEHP-caused
bursa
of
Fabricius
pyroptosis
necroptosis.
The
findings
demonstrated
reduced
the
expression
necroptosis
pyroptosis,
inhibited
mitogen-activated
protein
kinase
(MAPK)/NF-κB
pathway,
mitigated
oxidative
stress
caused
by
DEHP.
addition
reactive
oxygen
species
activator
(Sanguinarin)
raised
extent
stress,
NF-κB
(nuclear
factor-kappa-B
activator1,
act1)
activated
MAPK/NF-κB
pathway
compared
+
DEHP
group.
conclusion,
counteract
DEHP-induced
programmed
necrosis.
This
work
adds
toxicological
consequences
on
avian
further
theoretical
justification
for
Que's
treatment
organic
toxic
damage.
Land Degradation and Development,
Journal Year:
2024,
Volume and Issue:
35(15), P. 4596 - 4606
Published: July 24, 2024
Abstract
N‐(1,3‐dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine
(6PPD)
and
N‐(1,3‐Dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine‐quinone
(6PPD‐Q)
are
the
derivatives
of
tire
wear
particles
(TWPs)
that
can
enter
agricultural
environment.
Their
negative
consequences
on
environment
remain
unknown,
particularly
their
toxic
effects
edible
plants.
In
this
experiment,
toxicity
different
concentrations
6PPD
6PPD‐Q
pakchoi
(
Brassica
rapa
L.
ssp.
chinensis
)
was
explored
by
hydroponics.
The
results
revealed
seed
germination
inhibited
to
various
degrees.
However,
we
observed
an
increase
in
fresh
weight
seedling.
Environmental
concentration
(1
μg
L
−1
significantly
increased
ROS
levels
caused
changes
antioxidant
enzyme
activities.
MDA
content
elevated
under
treatment,
indicating
severe
oxidative
damage.
These
demonstrated
phytotoxicity
induced
6PPD‐Q,
which
is
great
significance
for
assessing
potential
ecological
risks
