Protective effect of zinc gluconate on intestinal mucosal barrier injury in antibiotics and LPS-induced mice

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Objective The aim of the study is to investigate function and mechanism Zinc Gluconate (ZG) on intestinal mucosal barrier damage in antibiotics Lipopolysaccharide (LPS)-induced mice. Methods We established a composite mouse model by inducing using LPS. animals were divided into five groups: Control (normal model) experimental (low, medium, high-dose ZG treatments). evaluated various methods, including monitoring body weight fecal changes, assessing pathological ultrastructure ileum, analyzing expression levels tight junction (TJ)-related proteins genes, confirming TLR4/NF-κB signaling pathway, examining structure flora. Results In mice, dual induction LPS led loss, abnormalities, disruption ileocecal structure, increased permeability, disorganization microbiota structure. restored weight, alleviated diarrheal symptoms damage, maintained structural integrity epithelial cells (IECs). Additionally, reduced permeability upregulating TJ-associated (ZO-1, Occludin, Claudin-1, JAM-A) downregulating MLCK, thereby repairing induced Moreover, suppressed demonstrating anti-inflammatory properties preserving integrity. Furthermore, gut diversity richness, evidenced Shannon Observed features indices, decreased Simpson’s index. also modulated relative abundance beneficial human bacteria ( Bacteroidetes , Firmicutes Verrucomicrobia Parabacteroides Lactobacillus Akkermansia ) harmful Proteobacteria Enterobacter ), administration Conclusion attenuates LPS-induced protects

Language: Английский

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From zinc homeostasis to disease progression: Unveiling the neurodegenerative puzzle

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107039 - 107039

Published: Dec. 19, 2023

Zinc is a crucial trace element in the human body, playing role various physiological processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair. The zinc transporters (ZnTs) family members are responsible for exporting intracellular zinc, while Zrt- Irt-like proteins (ZIPs) involved importing extracellular zinc. These essential maintaining cellular homeostasis. Imbalances metabolism have been linked to development of neurodegenerative diseases. Disruptions levels can impact survival activity neurons, thereby contributing progression diseases through mechanisms like cell apoptosis regulation, phase separation, ferroptosis, neuroinflammation. Therefore, conducting systematic review regulatory network investigating relationship between dysmetabolism enhance our understanding pathogenesis these Additionally, it may offer new insights approaches treatment

Language: Английский

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Dietary Citrus Flavonoids Improved Growth Performance and Intestinal Microbiota of Weaned Piglets via Immune Function Mediated by TLR2/NF-κB Signaling Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(30), P. 16761 - 16776

Published: July 16, 2024

This study investigated the effects of citrus flavonoids (CF) and compared to antibiotics on piglet growth gut health. Weaned piglets were fed either a basal diet (CON) or supplemented with 75 mg/kg chlortetracycline (CTC), 20 CF (CF1), 40 (CF2), 80 (CF3). The group, especially CF3, exhibited improved performance; reduced diarrhea; significantly higher levels serum factors, immunoglobulins, anti-inflammatory cytokines; lower pro-inflammatory factors markers intestinal barrier damage (

Language: Английский

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The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10040 - 10040

Published: Sept. 18, 2024

Weaning is one of the most challenging phases for piglets, and it also time when piglets are susceptible to diarrhea, which may result in significant economic losses pig production. One dietary strategies reducing post-weaning diarrhea (PWD) provide them with a pharmacological dose zinc oxide (ZnO). However, excessive or long-term usage high-dose ZnO has impacts on health ecological environment. Therefore, caution should be exercised considering use prevention treatment PWD piglets. In this paper, role animal health, potential mode action alleviating impact innovative, highly efficient alternatives regulation piglet were reviewed offer insights into application novel

Language: Английский

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Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Jan. 27, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

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Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Feb. 18, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

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Enhanced fast green dye degradation and biological activity of green synthesized Se@ZnO photocatalysts using Ficus religiosa plant extract

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

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Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: April 24, 2025

Heavy metal contamination has gradually become a highly significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These seep into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing very much important insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

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Bacillus amyloliquefaciens attenuates the intestinal permeability, oxidative stress and endoplasmic reticulum stress: transcriptome and microbiome analyses in weaned piglets

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: May 13, 2024

Endoplasmic reticulum (ER) stress is related to oxidative (OS) and leads intestinal injury. Bacillus amyloliquefaciens SC06 (SC06) can regulate OS, but its roles in ER remains unclear. Using a 2 × factorial design, 32 weaned piglets were treated by two levels (0 or 1 10 8 CFU/g), either with without diquat (DQ) injection. We found that increased growth performance, decreased ileal permeability, OS DQ-treated piglets. Transcriptome showed differentially expressed genes (DEGs) induced DQ enriched NF-κB signaling pathway. DEGs between DQ- + glutathione metabolism Ileal microbiome revealed the treatment Clostridium Actinobacillus . Correlations microbiota genes. In conclusion, dietary supplementation regulating microbiota.

Language: Английский

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Tecoma stans floral extract-mediated synthesis of MgFe2O4/ZnO nanoparticles for adsorption and photocatalytic degradation of coomassie brilliant blue dye

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(18), P. 26806 - 26823

Published: March 8, 2024

Language: Английский

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