INDIAN DRUGS,
Journal Year:
2023,
Volume and Issue:
60(08), P. 67 - 71
Published: Aug. 28, 2023
A
new,
accurate,
and
easy-to-use
UV-spectrophotometry
method
for
analyzing
favipiravir
in
both
bulk
tablet
forms
has
been
developed.
Favipiravir,
an
antiviral
drug,
is
classified
as
a
modified
pyrazine
analogue
also
known
6-fluoro-3-hydroxypyrazine-2-carboxamide.
The
drug’s
concentration
was
determined
by
measuring
zero-order
derivative
values
at
wavelength
of
323
nm.
linear
plot
constructed,
demonstrating
linearity
within
the
range
4-20
µg
mL-1,
with
impressive
correlation
coefficient
(r2)
0.9997
spectrophotometry
method.
method’s
limits
detection
(LOD)
quantification
(LOQ)
were
to
be
0.08
g
0.26
g,
respectively.
All
suggested
methods
rigorously
tested
make
sure
they
met
standards
set
International
Council
Harmonization
Technical
Requirements
Pharmaceuticals
Human
Use.
developed
are
characterized
their
linearity,
accuracy,
precision
sensitivity.
Journal of Pure and Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
18(1), P. 1 - 15
Published: Feb. 29, 2024
Antibiotics
are
an
essential
part
of
modern
healthcare,
revolutionizing
medicine
and
saving
countless
lives
worldwide.
However,
the
emergence
antimicrobial
resistance
(AMR)
is
a
growing
concern,
with
potential
to
cause
public
health
crisis
in
future.
The
aim
this
review
article
provide
overview
microbial
anthropogenic
factors
contributing
AMR,
as
well
consequences
inaction
address
AMR
crisis.
We
searched
various
international
databases
such
PubMed,
Scopus,
ScienceDirect
Google
Scholar
using
“Antimicrobial
Resistance”,”
Superbug”,
“Antibiotic
Stewardship”,
“One
Health’
“Surveillance”
search
keywords
different
combinations.
have
thoroughly
discussed
causes
overuse
misuse
antibiotics,
development
resistant
strains
bacteria.
also
suggested
possible
interventions
combat
one
approach,
antibiotic
stewardship
protocols,
application
artificial
intelligence
drug
design.
Additionally,
we
explored
benefits
traditional
ethnic
medicinal
practices
therapy.
In
conclusion,
emphasized
urgent
need
for
comprehensive
strategic
plan
issue
AMR.
Further
in-depth
research
novel
approaches
can
mitigate
menace
safeguard
both
human
animal
populations.
Applied and Environmental Microbiology,
Journal Year:
2024,
Volume and Issue:
90(11)
Published: Nov. 4, 2024
ABSTRACT
Horizontal
gene
transfer
(HGT)
is
a
major
process
by
which
genes
are
transferred
between
microbes
in
the
rhizosphere.
However,
examining
HGT
remains
challenging
due
to
complexity
of
mimicking
conditions
within
Fabricated
ecosystems
(EcoFABs)
have
been
used
investigate
several
complex
processes
plant-associated
environments.
Here
we
show
that
EcoFABs
efficient
tools
examine
and
measure
frequency
We
provide
first
demonstration
via
triparental
conjugation
system
Brachypodium
distachyon
rhizosphere
an
EcoFAB
using
Pseudomonas
putida
KT2440
as
both
donor
recipient
bacterial
strain
with
containing
mobilizable
non-self-transmissible
plasmid.
observed
plasmid
potentially
dependent
on
plant
developmental
stage
composition
amount
root
exudates.
The
also
increased
higher
numbers
cells.
demonstrate
from
P.
another
B.
colonizer,
Burkholderia
sp.
OAS925,
showing
microbial
community.
Environmental
stresses
influenced
rate
efficiency
different
species
genera.
This
study
provides
robust
workflow
evaluate
engineered
plasmids
when
such
introduced
field
or
other
IMPORTANCE
report
use
environment.
It
highlights
potential
recapitulating
dynamic
well
their
versatility
studying
plant-microbe
interactions.
emphasizes
importance
parameters
impacting
frequency.
Several
factors
stages,
nutrient
conditions,
number
cells,
environmental
influence
paves
way
for
future
investigations
into
understanding
fate
movement
INDIAN DRUGS,
Journal Year:
2023,
Volume and Issue:
60(08), P. 67 - 71
Published: Aug. 28, 2023
A
new,
accurate,
and
easy-to-use
UV-spectrophotometry
method
for
analyzing
favipiravir
in
both
bulk
tablet
forms
has
been
developed.
Favipiravir,
an
antiviral
drug,
is
classified
as
a
modified
pyrazine
analogue
also
known
6-fluoro-3-hydroxypyrazine-2-carboxamide.
The
drug’s
concentration
was
determined
by
measuring
zero-order
derivative
values
at
wavelength
of
323
nm.
linear
plot
constructed,
demonstrating
linearity
within
the
range
4-20
µg
mL-1,
with
impressive
correlation
coefficient
(r2)
0.9997
spectrophotometry
method.
method’s
limits
detection
(LOD)
quantification
(LOQ)
were
to
be
0.08
g
0.26
g,
respectively.
All
suggested
methods
rigorously
tested
make
sure
they
met
standards
set
International
Council
Harmonization
Technical
Requirements
Pharmaceuticals
Human
Use.
developed
are
characterized
their
linearity,
accuracy,
precision
sensitivity.
