Outdoor Light Spending Time, Genetic Predisposition and Incident Parkinson's Disease： The mediating effect of lifestyle and vitamin D

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Background Cross-sectional evidence implicates sunlight exposure is associated with the risk of Parkinson's disease (PD), whereas from prospective studies scarce. Methods A cohort study based on UK Biobank enrolled participants between 2006 and 2010, latest follow-up in November 2022. In population-based 375,599 adults aged 37–73 years were enrolled. The outdoor light time was assessed using a questionnaire survey to investigate how many hours spent outdoors typical summer winter days. New-onset PD identified through linkage inpatient hospitalization death registers. Multivariate Cox proportional hazard regression models used. polygenic score (PRS) for comprised 44 single-nucleotide variants. Results total (mean age, 56.8 years; 46.3% males) included, 2,824 individuals first-ever diagnosed PD. Compared shorter time, those longer (HR 0.77; 95% CI, 0.68–0.88), 0.85; 0.75–0.96), average 0.83; 0.74–0.93), prone have lower risk. There no interaction genetic predisposition mediation analyses, physical activities explained 13.24%, 25.72%, 15.55% associations PD, respectively. Conclusion this study, duration independent This association partly mediated by activity, vitamin D, sleep patterns.

Language: Английский

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Self‐Reported Outdoor Light Exposure Time and Incident Heart Failure

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(4)

Published: Feb. 13, 2024

Background A healthy lifestyle is an important factor for preventing heart failure. However, the association between outdoor light exposure time and failure still unknown. The aim of this study was to examine incidence Methods Results This cohort included participants from UK Biobank recruited 2006 2010 who were 40 70 years age free at baseline. mean follow‐up 12.61 years. self‐reported restricted cubic spline performed potential nonlinear relationship Cox proportional hazard models used estimate ratios (HRs) 95% CIs. During a years, 13 789 first diagnosed with There (J‐shaped) trend risk. regression showed that, compared received average 1.0 2.5 hours per day, those <1.0 or >2.5 had higher risk after model adjusted sex (<1.0 hours: HR, 1.27 [95% CI, 1.18–1.36]; 1.11 1.07–1.15]). These associations significant in fully 1.10 1.03–1.18]; 1.07 1.03–1.11]). Conclusions We found J‐shaped incident failure, suggesting that moderate may be prevention strategy

Language: Английский

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Association of time spent outdoors with the risk of Parkinson’s disease: a prospective cohort study of 329,359 participants

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 2, 2024

Abstract Background Studies on the association between time spent outdoors and development of Parkinson’s disease (PD) are lacking, whether this relationship differs in different subgroups (age, sex) remains unclear. Objective We here examined incidence PD seasons. Methods This study included 329,359 participants from UK Biobank. Data regarding hours during a typical day were obtained through questionnaires. Cox proportional hazard regression models used to estimate ratios (HRs) for exposure duration incidence. Restricted cubic spline was explore potential nonlinear risk. To mechanisms effecting risk incidence, their with serum vitamin D further analysed separately. Results During median follow-up 13.57 years, 2,238 developed PD. In summer, > 5.0 h/day associated reduced compared ≤ 2.0 (HR = 0.84, 95% CI, 0.74–0.95). winter too, also 1.0 0.85, 0.76–0.94). For annual average outdoors, who went more than 3.5 had those 1.5 0.75–0.96). Additionally, sex age differences observed Moreover, Time be positively levels. Compared D-deficient participants, by 15% sufficient participants. Conclusion total population, higher linked However, may vary among or groups.

Language: Английский

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Noise Exposure in the Workplace, Genetic Susceptibility, and Incidence of Atrial Fibrillation: A Prospective Cohort Study

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Background No study explored the association of noise exposure in workplace and genetic susceptibility with incidence atrial fibrillation (AF). We aimed to assess separate joint relationship risk AF. Methods Results included 167 577 participants without AF at baseline UK Biobank. Cox proportional hazards models were used During a median follow‐up 11.83 years, we observed 9355 cases. Compared no workplace, hazard ratios (HRs) 1.08 (95% CI, 0.99–1.18) for <1 year, 1.03 0.95–1.12) around 1 5 1.02–1.14) >5 respectively, after adjusting potential confounders. Genetic was positively associated AF, compared low (tertile 1), HRs 1.50 1.41–1.59) medium 2) 2.51 2.38–2.65) high 3). However, interaction between ( P >0.05). Conclusions Long‐term is higher regardless background.

Language: Английский

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Time spent in outdoor light is associated with increased blood pressure, increased hypertension risk, and decreased hypotension risk

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 288, P. 117349 - 117349

Published: Nov. 18, 2024

Language: Английский

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