Wastewater-Based Surveillance of Respiratory Syncytial Virus Epidemic at the National Level in Finland DOI Creative Commons
Annika Länsivaara, K. Lehto, Rafiqul Hyder

et al.

ACS ES&T Water, Journal Year: 2024, Volume and Issue: 4(6), P. 2403 - 2411

Published: May 9, 2024

The purpose of this study was to evaluate the potential wastewater-based surveillance in monitoring epidemics at national level Finland. 2021–2022 respiratory syncytial virus epidemic Finland analyzed from wastewater and Finnish National Infectious Diseases Register. performed using 150 samples that were collected monthly May 2021 July 2022 ten treatment plants cover 40% population. Respiratory detection 24 h composite influent reverse-transcription quantitative polymerase chain reaction (RT-qPCR). data positively correlated with Register-based sampling week incidence (correlation coefficient, CC min = 0.412, max 0.865) four-week cumulative (CC 0.482, 0.814), showing estimating course epidemics. When register-based least four cases/100,000 persons/sampling week, it detected all samples. This showed can be used surveil level, its other should explored further.

Language: Английский

Observations of Respiratory Syncytial Virus (RSV) Nucleic Acids in Wastewater Solids Across the United States in the 2022–2023 Season: Relationships with RSV Infection Positivity and Hospitalization Rates DOI Creative Commons
Alessandro Zulli, Meri R.J. Varkila, Julie Parsonnet

et al.

ACS ES&T Water, Journal Year: 2024, Volume and Issue: 4(4), P. 1657 - 1667

Published: Feb. 29, 2024

Respiratory syncytial virus (RSV) is a leading cause of respiratory illness and hospitalization, but clinical surveillance detects only minority cases. Wastewater could determine the onset extent RSV circulation in absence sensitive case detection, to date, studies wastewater are few. We measured RNA concentrations solids from 176 sites during 2022–2023 season compared those publicly available infection positivity hospitalization rates. Concentrations ranged undetectable 107 copies per gram. concentration aggregated at state national levels correlated with was determined using both rates independent algorithms for 14 states where data were start season. In 4 states, identified same week; 3 preceded onset, 7 occurred after onset. generally peaked week as peaked. Differences peaks versus may reflect inherent differences approaches.

Language: Английский

Citations

13
Case report: Zika surveillance complemented with wastewater and mosquito testing DOI Creative Commons
Judith Chui Ching Wong,

Martin Tay,

Hapuarachchige Chanditha Hapuarachchi

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 101, P. 105020 - 105020

Published: Feb. 21, 2024

In June 2023, a local cluster of 15 Zika cases was reported in neighbourhood Northeastern Singapore. The last significant transmission virus (ZIKV) with more than 450 2016-2017. To monitor the situation and mitigate further transmission, case, entomological wastewater-based surveillance were carried out.

Language: Английский

Citations

11
Urban wastewater-based epidemiology for multi-viral pathogen surveillance in the Valencian region, Spain DOI Creative Commons
Inés Girón‐Guzmán, Enric Cuevas‐Ferrando, Regino Barranquero

et al.

Water Research, Journal Year: 2024, Volume and Issue: 255, P. 121463 - 121463

Published: March 16, 2024

Wastewater-based epidemiology (WBE) has lately arised as a promising tool for monitoring and tracking viral pathogens in communities. In this study, we analysed WBE's role multi-pathogen surveillance strategy to detect the presence of several illness causative agents. Thus, an epidemiological study was conducted from October 2021 February 2023 estimate weekly levels Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Syncytial virus (RSV), Influenza A (IAV) influent wastewater samples (n = 69). parallel, one-year (October 2022) performed assess pathogenic human enteric viruses. Besides, proposed fecal contamination indicators crAssphage Pepper mild mottle (PMMoV) also assessed, along with plaque counting somatic coliphages. Genetic material rotavirus (RV), astrovirus (HAStV), norovirus genogroup I (GI) GII found almost all samples, while hepatitis E viruses (HAV HEV) only tested positive 3.77 % 22.64 respectively. No seasonal patterns were overall viruses, although RVs had peak prevalence winter months. All SARS-CoV-2 RNA, mean concentration 5.43 log genome copies per liter (log GC/L). The circulating variants concern (VOCs) by both duplex RT-qPCR next generation sequencing (NGS). Both techniques reliably showed how dominant VOC transitioned Delta Omicron during two weeks Spain December 2021. RSV IAV peaked months concentrations 6.40 4.10 GC/L, Moreover, three selected respiratory strongly correlated reported clinical data when normalised physico-chemical parameters presented weaker correlations normalising sewage or coliphages titers. Finally, predictive models generated each virus, confirming high reliability on WBE early-warning system communities system. Overall, presents optimal reflecting circulation diseases trends within area, its value stands out due public health interest.

Language: Английский

Citations

10
Seasonality of respiratory, enteric, and urinary viruses revealed by wastewater genomic surveillance DOI Creative Commons

Matthew F. Smith,

R Maqsood,

Regan A. Sullins

et al.

mSphere, Journal Year: 2024, Volume and Issue: 9(5)

Published: May 7, 2024

ABSTRACT Wastewater surveillance can reveal population-level infectious disease burden and emergent public health threats be reliably assessed through wastewater surveillance. While molecular methods for monitoring of microorganisms have traditionally relied on PCR-based approaches, next-generation sequencing (NGS) provide deeper insights via genomic analyses multiple diverse pathogens. We conducted a year-long 1,408 composite samples collected from 12 neighborhood-level access points in the greater Tempe area, Arizona, USA, show that variation viruses is driven by seasonal time location. The temporal dynamics were influenced cyclically, with most dissimilarity between 23 weeks apart (i.e., winter vs summer, spring fall). identified urinary enteric including polyomaviruses, astroviruses, noroviruses, showed their genotypes/subtypes shifted across seasons. while data certain respiratory like severe acute syndrome coronavirus 2 (SARS-CoV-2) strongly correlate clinical case rates, laboratory-reported incidences discordant surges high viral load other human 229E. These results demonstrate utility informing decision-making health. IMPORTANCE into spread pathogens communities. Advances methodologies allow more precise detection wastewater. Long-term an important tool preparedness. This system act as observatory gives real-time early warning outbreaks improved response times.

Language: Английский

Citations

9
Characterising the asynchronous resurgence of common respiratory viruses following the COVID-19 pandemic DOI Creative Commons
Chenkai Zhao, Tiantian Zhang, Ling Guo

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 13, 2025

Abstract The COVID-19 pandemic and relevant non-pharmaceutical interventions (NPIs) interrupted the circulation of common respiratory viruses. These viruses demonstrated an unprecedented asynchronous resurgence as NPIs were relaxed. We compiled a global dataset from systematic review, online surveillance reports unpublished data Respiratory Virus Global Epidemiology Network, encompassing 92 sites. compared timings within each site synthesised differences in across sites, using generalised linear mixed-effects model. revealed distinct sequential timing first post-pandemic resurgence: rhinovirus resurged earliest, followed by seasonal coronavirus, parainfluenza virus, syncytial adenovirus, metapneumovirus influenza A with B virus exhibiting latest resurgence. Similar was observed second except caught up metapneumovirus. consistent asynchrony geographical regions suggests that virus-specific characteristics, rather than location-specific factors, determining relative

Language: Английский

Citations

1
Adapted methods for monitoring influenza virus and respiratory syncytial virus in sludge and wastewater DOI Creative Commons
Daniel Toribio-Avedillo, Clara Gómez-Gómez, Laura Sala‐Comorera

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170636 - 170636

Published: Feb. 6, 2024

Wastewater-based surveillance constitutes a valuable methodology for the continuous monitoring of viral circulation, with capacity to function as an early warning system. It holds particular significance in scenarios where respiratory viruses exhibit overlapping clinical presentations, occurs SARS-CoV-2, influenza virus (IV), and syncytial (RSV), allows seasonal outbreaks be distinguished from COVID-19 peaks. Furthermore, sewage sludge, given it harbors concentrated human waste large population, serves substantial reservoir pathogen detection. To effectively integrate wastewater-based epidemiology into infectious disease surveillance, detection methods employed wastewater samples must adapted distinct characteristics sludge matrices. In this study, we applied protocols IV RSV comparing their performance results obtained wastewater. assess efficiency these protocols, were spiked RNA, either free or incorporated lentiviral particles. Samples using aluminum hydroxide adsorption-precipitation method before RNA extraction. Absolute quantification was carried out by RT-qPCR, including internal control monitor potential inhibitory factors. Recovery efficiencies both 60 % 75 71 respectively wastewater, whereas values particles 16 10 21 17 respectively. Additionally, protocol enabled naturally occurring collected two treatment plants during winter months, thus affirming efficacy methodologies.

Language: Английский

Citations

6
Tracking diarrhea viruses and mpox virus using the wastewater surveillance network in Hong Kong DOI

Xiawan Zheng,

Keyue Zhao,

Bingjie Xue

et al.

Water Research, Journal Year: 2024, Volume and Issue: 255, P. 121513 - 121513

Published: March 24, 2024

Language: Английский

Citations

6
Leveraging wastewater surveillance to detect viral diseases in livestock settings DOI
Warish Ahmed, Yawen Liu, Wendy Smith

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172593 - 172593

Published: April 18, 2024

Language: Английский

Citations

6
Quantification of multiple respiratory viruses in wastewater in the Kathmandu Valley, Nepal: Potential implications of wastewater-based epidemiology for community disease surveillance in developing countries DOI

Sunayana Raya,

Bikash Malla, Sadhana Shrestha

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 920, P. 170845 - 170845

Published: Feb. 8, 2024

Language: Английский

Citations

5
Estimating the COVID-19 prevalence from wastewater DOI Creative Commons
Jan Möhring, Neele Leithäuser,

Jarosław Wlazło

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 22, 2024

Wastewater based epidemiology has become a widely used tool for monitoring trends of concentrations different pathogens, most notably and widespread SARS-CoV-2. Therefore, in 2022, also Rhineland-Palatinate, the Ministry Science Health included 16 wastewater treatment sites surveillance program providing biweekly samples. However, mere viral load data is subject to strong fluctuations limited value political deciders on its own. state Rhineland-Palatinate commissioned University Medical Center at Johannes Gutenberg Mainz conduct representative cohort study called SentiSurv, which an increasing number up 12,000 participants have been using sensitive antigen self-tests once or twice week test themselves SARS-CoV-2 report their status. This puts fortunate position having time series both, prevalence population. Our main contribution calibration from 2023-01-08 until 2023-10-01 where we identified scaling factor ( 0.208±0.031 ) delay 5.07±2.30 days) between virus wastewater, normalized by pepper mild mottle (PMMoV), recorded SentiSurv study. The relation established fitting epidemiological model both series. We show how that can be estimate when no longer available use it as forecasting instrument several weeks ahead time. quality resulting factors depend strongly samples are normalized.

Language: Английский

Citations

5