The Impact of the Reduction in Environmental Pollution during COVID-19 Lockdown on Healthy Individuals DOI Creative Commons
Christian Romero‐Mesones, De M, David Soler-Segovia

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(7), P. 492 - 492

Published: July 4, 2024

The lockdown imposed to combat the COVID-19 pandemic produced a historic fall in air pollution cities like Barcelona. This exceptional situation offered unique context which examine effects of pollutants on human health. present study aims determine and compare oxidative stress biomarkers Th1/Th2 inflammatory-related cytokines healthy individuals first during then six months after easing restrictions mobility. A prospective representative sample 58 healthy, non-smoking adults was carried out. During post-easing restrictions, blood samples were drawn measure percentage eosinophils, levels assessed by multiplex assay (BioRad Laboratories S.A., Marnes-la-Coquette, France), 8-isoprostane, glutathione peroxidase activity, myeloperoxidase (Cayman Chemical Co., Ann Arbor, MI, USA), assess their value as stress. Six mobility increases 8-isoprostane (p < 0.0001), IL-1β = 0.0013), IL-1ra 0.0110), IL-4 IL-13 G-CSF 0.0007), CCL3 0.0001) recorded, along with reductions IFN-γ 0.0145), TNFα IP-10 IL-2 IL-7 basic FGF CCL4 CCL5 0.0001). No significant differences observed rest analyzed. reduction environmental significantly lowered stress, systemic inflammation, Th2-related people.

Language: Английский

Contribution of Road Vehicle Tyre Wear to Microplastics and Ambient Air Pollution DOI Open Access
Barouch Giechaskiel, Theodorοs Grigoratos, Marcel Mathissen

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(2), P. 522 - 522

Published: Jan. 7, 2024

Tyre particles are generated by shear forces between the tread and road or volatilisation. abrasion (wear) contributes from one-third to half of microplastics unintentionally released into environment. The major part ends up in soil, a considerable amount is aquatic environment, small percentage becomes airborne. Nevertheless, tyre 5–30% transport particulate matter (PM) emissions. This corresponds approximately 5% total ambient PM particle mass size distribution peak at around 20 100 μm, with second 2–10 μm range. A nucleation mode has been reported some studies. absolute levels depend on tyre, vehicle, characteristics, but also environmental conditions driving style. Most emission factors literature based data prior year 2000. We aggregated recent studies found mean 110 mg/km per vehicle 68 mg/km/t for passenger cars (based 300 measurements). Based limited number studies, PM10 emissions were 1.4–2.2 tyre. On other hand, order 1010 #/km ratio was be 2.5% average. Finally, PM2.5 calculated 40%. Various mitigation measures pollution could envisaged; most direct limitation rate, as proposed European Commission Euro 7 regulation. Other regulatory initiatives discussed.

Language: Английский

Citations

41
Abundance and risk assessment of microplastics in water, sediment, and aquatic insects of the Nile River DOI

Azza M. Khedre,

Somaia A. Ramadan,

Ali Ashry

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 353, P. 141557 - 141557

Published: Feb. 26, 2024

Language: Английский

Citations

22
Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis DOI Creative Commons
Jessy Le Du-Carrée,

Clara Kempkens Palacios,

Anna Rotander

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134401 - 134401

Published: April 25, 2024

Tire wear particles (TWP) stand out as a major contributor to microplastic pollution, yet their environmental impact remains inadequately understood. This study delves into the cocktail effects of TWP leachates, employing molecular, cellular, and organismal assessments on diverse biological models. Extracted in artificial seawater analyzed for metals organic compounds, leachates revealed presence polyaromatic hydrocarbons 4-tert-octylphenol. Exposure (1.5 1000 mg peq L−1) inhibited algae growth induced zebrafish embryotoxicity, pigment alterations, behavioral changes. Cell painting uncovered pro-apoptotic changes, while mechanism-specific gene-reporter assays highlighted endocrine-disrupting potential, particularly antiandrogenic effects. Although heavy like zinc have been suggested players leachate toxicity, this emphasizes water-leachable compounds primary causative agents observed acute toxicity. The findings underscore need reduce pollution aquatic systems enhance regulations governing highly toxic tire additives. pose significant threat, contributing releasing harmful chemical contaminants. unveils hazardous nature introducing detrimental ecosystems. Identified pollutants, notably hydrocarbons, induce impede growth, alter behavior, disrupt signaling pathways. These revelations emphasize material affecting life at multiple levels, posing risks health both ecosystems and, potentially, human well-being. Enhancing our understanding mechanisms is crucial mitigating these safeguarding from deleterious

Language: Английский

Citations

13
Exposure to complex mixtures of urban sediments containing Tyre and Road Wear Particles (TRWPs) increases the germ-line mutation rate in Chironomus riparius DOI Creative Commons
Lorenzo Rigano, Markus Schmitz, Volker Linnemann

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 281, P. 107292 - 107292

Published: Feb. 16, 2025

Tyre and road wear particles (TRWPs) are a significant yet often underestimated source of environmental pollution, contributing to the accumulation microplastics complex mixture contaminants in both terrestrial aquatic ecosystems. Despite their prevalence, long-term evolutionary effects TRWPs, beyond immediate toxicity, remain largely unknown. In this study, we assessed mutagenicity non-biting midge Chironomus riparius, upon exposure urban sediment collected from runoff sedimentation basin. To assess extent mutagenic over multiple generations, combined model with short-term mutation lines (MALs) subsequent whole genome sequencing (WGS). The study was conducted five concentrations 0.5 % 10 %. Our results reveal that significantly increases rates compared control groups by 50 %, independent concentration (0.5 %). infer potential causal processes, comparative analysis using known mutational spectra previous studies. This comparison showed profiles induced clearly clustered those caused Benzo[a]Pyrene (BaP), Polycyclic Aromatic Hydrocarbon (PAH). A comprehensive chemical characterization confirmed considerable impact traffic-related contamination, including PAHs primarily petrogenic origin. suggests PAH-like compounds present sediments may play role observed effects. shows influence alter exposed organisms, potentially compromising genomic stability shaping trajectories. These genetic changes can have profound on population dynamics ecosystem health, underlining importance understanding consequences pollution. Additionally, show comparatively analysing provide valuable insights into processes.

Language: Английский

Citations

1
Accumulation and depuration of tire wear particles in zebrafish (Danio rerio) and toxic effects on gill, liver, and gut DOI
Yun Zhang, Tianyu Zhao, Yanan Zhang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175625 - 175625

Published: Aug. 18, 2024

Language: Английский

Citations

8
Combined toxicity of pristine or artificially aged tire wear particles and bisphenols to Tigriopus japonicus DOI
Jinbo Song,

Qian Meng,

Hongyu Song

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142894 - 142894

Published: July 17, 2024

Language: Английский

Citations

5
Tracking the biogeochemical behavior of tire wear particles in the environment – A review DOI
Qiao Xu, Syed Shabi Ul Hassan Kazmi, Gang Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136184 - 136184

Published: Oct. 17, 2024

Language: Английский

Citations

5
Biological effects of brake wear particles in mammalian models: A systematic review DOI Creative Commons
Valérie Forest, Jérémie Pourchez

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167266 - 167266

Published: Sept. 22, 2023

Language: Английский

Citations

11
An in vitro comparison of the toxicological profiles of ground tire particles (TP) and actual tire and road wear particles (TRWP) emissions DOI Creative Commons

Abderrahmane Bouredji,

Bogdan Muresan, Xuan-Trinh Truong

et al.

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108885 - 108885

Published: July 14, 2024

There is currently limited data on the potential effects of tire and road wear particles (TRWP) human health. TRWP include fragments, but also materials, dust, adsorbed gaseous pollutants different types inclusions that could affect their hazard profiles. Due to availability lower complexity, ground (TP) are often used in toxicological studies. However, this makes it difficult draw firm conclusions about actual TRWP. Here, we compared vitro profile TP emissions similar size collected from traffic. For purpose, were separately incubated with alveolar macrophages for 24 h, cellular response was evaluated terms cytotoxicity, proinflammatory oxidative stress. Both induced neither significant cytotoxicity nor stress, triggered a concentration-dependent response, as evidenced by increased TNF-α production. The level production slightly higher than TP, independent particle dose. All all, pulmonary toxicity be due primarily tread only marginally other components (i.e. dust …). Although these preliminary results need confirmed further analysis, they useful manufacturers safer-by-design tires.

Language: Английский

Citations

4
A study of the direct emission of tire wear particles on different types of roads DOI Creative Commons
Bogdan Muresan, Xuan-Trinh Truong, Tiago De Oliveira

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 958, P. 178018 - 178018

Published: Dec. 13, 2024

Language: Английский

Citations

3