The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 959, P. 178291 - 178291
Published: Dec. 29, 2024
Language: Английский
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172303 - 172303
Published: April 9, 2024
Language: Английский
Citations
7
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 281, P. 116590 - 116590
Published: June 20, 2024
Exposure to light at night (LAN) has been associated with multiple adverse health outcomes. However, evidence is limited regarding the impacts of LAN exposure on human inflammation. To examine association between real-ambient bedroom systemic inflammation and circadian rhythm inflammatory markers. Using data from a prospective cohort study Chinese young adults. At baseline, was measured portable illuminance meter; fasting blood sample for high-sensitivity C-reactive protein (hs-CRP) assay collected. 3-year follow-up, 20 healthy adults (10 LANavg < 5 lx, 10 ≥ lx) were recruited same cohort; time-series venous samples sampled every 4 h over 24 h-cycle detection 8 Circadian markers assessed using cosinor analysis. average age 276 participants 18.7 years, 33.3 % male. Higher levels significantly increased hs-CRP levels. The only significant in inactive group (MVPA 2 h/d) but not physically active h/d). In addition, higher nighttime (LANavg disrupted rhythms (including rhythmic expression, amplitude phase) some cytokines balance indicators. increases disrupts Keep darkness may represent important strategies prevention chronic Additionally, people living community pollution, regular physical activity be viable option counteract negative
Language: Английский
Citations
5
Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109344 - 109344
Published: Feb. 21, 2025
Language: Английский
Citations
0
Environmental Sciences Europe, Journal Year: 2025, Volume and Issue: 37(1)
Published: March 12, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 22, 2025
Polycyclic aromatic hydrocarbons (PAHs) pollution and hearing loss are important issues in the environment public health. However, current research still lacks data on their association real-world environments. This study included 658 American adults who participated National Health Nutrition Examination Survey (NHANES) from 2015 to 2016. The correlation between single PAH exposure was estimated by weighted logistic regression, overall mixed PAHs evaluated Bayesian kernel machine regression grouped quantile sum chemicals were identified this study. results showed that 1-Hydroxynaphthalene (1-OHNa) positively correlated with condition, level threshold (OR = 1.41, 95% CI 1.08-1.84, P < 0.01; OR 1.04-1.87, 0.05; 4.34, 1.74-10.81, 0.01, respectively). And 1-Hydroxypyrene (1-OHP) condition 1.83, 0.99-3.36, 5.83, 1.31-26.03, 0.05, respectively) after using covariate correction. of BKMR WQS indicated a positive decreased hearing, higher PAHs, greater risk loss. Further analysis revealed 1-OHP an chemical substance related hearing. result consistent model. These insights provide critical new perspective highlighting urgent need for strategies reduce environmental protect human
Language: Английский
Citations
0
BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 30, 2025
Epidemiological studies that have simultaneously explored the effects of placental and cord blood inflammatory cytokine levels on neurodevelopment in offspring, as well role maternal vitamin D these associations, are lacking. To investigate associations with 18-month-old children, potential modification effect by D. Based Ma'anshan birth cohort, current study involved 1241 mother-child pairs. The mRNA expression levels, serum concentrations, concentrations were determined. Children's neurodevelopmental outcomes defined Chinese version Ages Stages Questionnaire (Third Edition) subdomain scores below established cutoff scores. Generalized linear models utilized to assess cytokines examine After adjusting for confounders, each one-unit increase IL-6 (OR = 1.30, 95% CI: 1.09, 1.55, P-FDR 0.024), IL-8 1.25, 1.05, 1.49, 0.036), IFN-γ level 1.74, 1.16, 2.61, 0.042) was associated an increased risk fine motor delay. Elevated TNF-α 1.38, 1.12, 1.69, 0.012), 1.29, 1.04, 1.61, 0.042), 1.31, 1.06, 1.62, 0.036) personal-social Stratified analyses showed lower (< 20 ng/mL) moderated between markers delays motor, gross subdomains. specific placenta umbilical developmental a parental-reported screening tool. Maternal status can modify adverse intrauterine pro-inflammatory milieu children.
Language: Английский
Citations
0
Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Abstract Humans and animals possess robust immune systems to safeguard against foreign pathogens. However, recent reports suggest a greater incidence of immunity breakdown due exposure environmental pollutants, with heavy metals emerging as potential candidates in such immuno‐toxicological studies. While we have extensive data on the general toxicity resulting from metals, comprehensive documentation their role disruptors remains scarce. Cd (Cadmium) exerts immunomodulation by interfering organs cells, leading altered structure, physiology, function, thereby inducing symptoms deregulation, inflammation and/or autoimmunity. This review aims summarize link between dysfunction, drawing case studies exposed human subjects, well research conducted various model organisms in‐vitro culture systems.
Language: Английский
Citations
2
Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 316 - 316
Published: April 26, 2024
Objective: We aimed to investigate the relationship between metal exposure and novel immunoinflammatory indicators. Methods: Data on adults participating in National Health Nutrition Examination Survey (NHANES) from 2009 2018 were analyzed. Various statistical models employed assess association immune-inflammation-related Additionally, impact of inflammation different gender populations was explored. Results: This study included 4482 participants, whom 51.1% male. Significant correlations observed among various metals. Both elastic net (ENET) linear regression revealed robust associations cadmium (Cd), cobalt (Co), arsenic (As), mercury (Hg), Weighted quantile sum (WQS) Quantile g-computation (Q-gcomp) demonstrated strong barium (Ba), Co, Hg Bayesian kernel machine (BKMR) analysis indicated an overall positive correlation vivo urinary levels systemic response index (SIRI) aggregate (AISI). Furthermore, As, emerged as key metals contributing changes Conclusions: Metals exhibit with emerging indicators, concurrent mixed may exacerbate inflammatory response. this varies across populations.
Language: Английский
Citations
1
Science Advances, Journal Year: 2024, Volume and Issue: 10(48)
Published: Nov. 29, 2024
Fine particulate matter (PM 2.5 ) exposure can induce immune system pathology via epigenetic modification, affecting pregnancy outcomes. Our study investigated the association between PM and response, as well changes using high-dimensional landscape profiling cytometry by time-of-flight (EpiTOF) at single cell. We found statistically significant associations levels of certain cytokines [interleukin-1RA (IL-1RA), IL-8/CXCL8, IL-18, IL-27)] histone posttranslational modifications (HPTMs) in cells (HPTMs: H3K9ac, H3K23ac, H3K27ac, H2BK120ub, H4K20me1/3, H3K9me1/2) among pregnant nonpregnant women. The cord blood neonates with high maternal showed lower IL-27 than those low exposure. Furthermore, affects co-modification profiles women their neonates, along HPTMs each cell type These specific histones could indicate toxicological mechanism inflammation, inflammasome pathway, complications.
Language: Английский
Citations
1
Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 21, 2024
Abstract Objective To explore the relationship between 35 trace metals in scalp hair and glioma risk as well potential mediating roles of 27 plasma inflammatory cytokines. Methods A case–control study involving 228 participants was performed southeastern China. Trace were analyzed using inductively coupled mass spectrometry, multiplex cytokines detected based on Luminex® technology. The least absolute shrinkage selection operator (LASSO) regression combination with four machine learning methods used to select associated gliomas. joint exposure effect estimated generalized weighted quantile sum (gWQS) quantile‐based g‐computation (qgcomp) algorithms. Results Both LASSO random forest algorithms identified five (gadolinium [Gd], lithium [Li], thulium [Tm], thorium [Th], molybdenum [Mo]) After adjustments for confounders, Gd (odds ratio [OR] = 2.84, 95% confidence interval [CI]: 1.89–4.43) Li (OR 1.77, CI: 1.04–3.02) concentrations positively risk, while Tm 0.36, 0.17–0.73) Th 0.45, 0.28–0.71) exhibited inverse associations. gWQS qgcomp showed contributed most mixture effect. Moreover, there a significant interaction or ( p < 0.05). Notably, granulocyte–macrophage colony‐stimulating factor (GM‐CSF) mediated association by 25.75%. Interpretation These findings suggest associations certain metals, especially Gd, may provide new insights into mechanisms underlying from an response perspective.
Language: Английский
Citations
0