Assessment of the level of apoptosis in differentiated pseudo-neuronal cells derived from neural stem cells under the influence of various inducers DOI

Adele Naghshbandieh,

Atefe Naghshbandieh,

Elahe Barfi

et al.

American Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 250 - 270

Published: Jan. 1, 2024

Development and maintenance of the nervous system are governed by a scheduled cell death mechanism known as apoptosis. Very much how neurons survive function depends on degree in differentiating pseudo-neuronal cells produced from neural stem cells. Different inducers can affect these cells: hormones, medicines, growth factors, others. Developing inventive therapies for neurodegenerative illnesses knowledge impact mortality differentiated Using flow cytometry, Western blotting, fluorescence microscopy among other techniques, many is evaluated. Flow cytometry generates dead counts measurements size, granularity, DNA content. Whereas visualizes using fluorescent dyes or antibodies, blotting detects caspases Bcl-2 family proteins. This review attempts to offer thorough investigation present studies under effect different inducers. Through investigating influence death, aims provide information that might direct next support treatment plans diseases. With an eye toward like retinoic acid, selegiline, cytokines, valproic small compounds, we examined research evaluate rates. The findings important new perspectives molecular processes guiding There still complete lack understanding factors lead so contribute therapeutic approaches treat

Language: Английский

High performance epoxy soybean oil-based composite reinforced by wood powder DOI
Weicong Wang, Rui Luo,

Shuduan Deng

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 211, P. 118195 - 118195

Published: Feb. 12, 2024

Language: Английский

Citations

6
Tetrabromobisphenol A, but not bisphenol A, disrupts plasma membrane homeostasis in myeloid cell models – A novel threat from an established persistent organic pollutant DOI Creative Commons
Leila Khani, Maciej Studzian, Leonardo Martins

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 961, P. 178284 - 178284

Published: Jan. 1, 2025

Bisphenol A (BPA, a plastic polymer component) and tetrabromobisphenol (TBBPA, brominated flame retardant) are industrial compounds representative persistent organic pollutants (POPs) with similar chemical structure. We studied their impact on biological membrane dynamics, which is an emerging understudied target for environmental contaminants, using set of state-of-the-art methods. found that exposure to TBBPA, but not BPA, leads disruption biophysical homeostasis the plasma in myeloid cell lines HL-60, THP-1 Mono Mac 6. Applied methods include: pyrene excimer formation, fluorescence anisotropy, solvatochromic shift ratiometry (using di-4-ANEPPDHQ, NR12A laurdan) recovery after photobleaching. TBBPA increased rotational lateral mobility decreased general polarity lipid order membranes cells, rigidity internal same cells. Strikingly, BPA had no significant effects these suggesting specific molecular interaction mechanism action may potentially lead immune function. Identification this novel threat from established pollutant documented pathways highlights possibility immunotoxicity POPs contribute toxicity burden.

Language: Английский

Citations

0
High-value added utilization of magnesium resource in brine via indirect CO2 mineralization to synthesize MgCO3⸱3H2O whiskers for excellent flame retardant DOI
Dapeng Zhang, Shuo Yan, Hongfei Guo

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115404 - 115404

Published: Jan. 1, 2025

Language: Английский

Citations

0
Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure DOI
Zhihao Hou, Z. Shi,

Zhen Lu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137550 - 137550

Published: Feb. 10, 2025

Language: Английский

Citations

0
Recent advancement in Mxene-based nanomaterials for flame retardant polymers and composites DOI Creative Commons
Yakubu Adekunle Alli, Abayomi Bamisaye, Onome Ejeromedoghene

et al.

Advanced Industrial and Engineering Polymer Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Environmental concentrations of TCEP and TDCIPP induce dysbiosis of gut microbiotal and metabolism in the honeybee (Apis mellifera L.) DOI

Tao Cang,

Weijie Gu,

Yu Cheng Zhu

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138039 - 138039

Published: March 1, 2025

Language: Английский

Citations

0
Association between exposure to brominated flame retardants (BFRs) and blood lipid profiles in American adults: a cross-sectional study DOI Creative Commons
Yuxuan Wang, Zhihao Zhang, Nana Shen

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 27, 2025

Exposure to brominated flame retardants (BFRs) has been linked alterations in human metabolism and disease processes. However, the relationship between BFR exposure blood lipid levels remains unclear. This study aimed investigate potential association profiles American adults. A cross-sectional was conducted using data from National Health Nutrition Examination Survey (NHANES) 2005–2016. Serum concentrations of twelve BFRs, PBB153 eleven polybrominated diphenyl ethers (PBDEs), were quantified isotope dilution gas chromatography/high-resolution mass spectrometry (GC/HRMS). Blood levels, including total cholesterol (TC) high-density lipoprotein (HDL-C) measured enzymatically. The Friedewald equation used determine low-density (LDL-C): [LDL-C] = [TC] − [HDL-C] [TG/5]. Remnant (RC) calculated formula: [RC] [LDL-C]. Multivariable regression analyses applied examine associations individual BFRs TC, HDL-C, LDL-C, RC. overall mixtures with lipids evaluated quantile g-computation (QGC) weighted sum (WQS) regression. In order identify gender-specific differences, stratified mixture performed by gender. 3,154 eligible participants included. Nine a detection rate greater than 70% included analysis. Individually, PBB153, PBDE209, PBDE153, PBDE28 positively associated TC RC after adjusted all covariates. Furthermore, PBDE153 LDL-C. No found HDL-C. WQS QGC confirmed that demonstrates is increased RC, indicating an elevated risk dyslipidemia cardiovascular diseases.

Language: Английский

Citations

0
Assessment of membrane and metabolic parameters of erythrocytes exposed to selected bromophenols DOI Creative Commons
Monika Jarosiewicz, Piotr Duchnowicz, Bożena Bukowska

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

Language: Английский

Citations

0
A Review of the Association between Exposure to Flame Retardants and Thyroid Function DOI Creative Commons
Brandon Yeshoua, Horacio Romero Castillo,

Mathilda Monaghan

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1365 - 1365

Published: June 19, 2024

Flame retardants have been shown to cause widespread physiological effects, in particular on endocrine organs such as the thyroid. This review aims provide an overview of literature association between flame and thyroid function within humans. A search National Library Medicine Institutes Health PubMed database through January 2024 yielded 61 studies that met inclusion criteria. The most frequently analyzed across all hormones were polybrominated diphenyl ethers (PBDEs), BDE-47 BDE-99. Ten demonstrated exclusively positive associations stimulating hormone (TSH). Six negative TSH. Twelve for total triiodothyronine (tT3) thyroxine (tT4). Five eight these same hormones, respectively. effect is heterogeneous; however, long-term impact warrants further investigation. Vulnerable populations, including indigenous people, individuals working at e-waste sites, firefighters, certain age groups, children elderly, are especially critical be informed risk exposure.

Language: Английский

Citations

3
Relationship between flame retardants and respiratory health– A systematic review and meta-analysis of observational studies DOI Creative Commons
Sónia D. Coelho, Tiago Maricoto, Luís Taborda‐Barata

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 347, P. 123733 - 123733

Published: March 6, 2024

Chronic respiratory diseases are a dealing cause of death and disability worldwide. Their prevalence is steadily increasing the exposure to environmental contaminants, including Flame Retardants (FRs), being considered as possible risk factor. Despite widespread continuous FRs, role these contaminants in chronic yet not clear. This study aims systematically review association between FRs diseases. Searches were performed using Cochrane Library, MEDLINE, EMBASE, PUBMED, SCOPUS, ISI Web Science (Science Social Index), WHO Global Health Library CINAHL EBSCO. Among initial 353 articles found, only 9 fulfilled inclusion criteria included. No statistically significant increase for with was found therefore there enough evidence support that pose significantly higher development or worsening However, non-significant trend potential hazard asthma rhinitis/rhinoconjunctivitis, particularly considering urinary organophosphate esters (OPEs) TNBP, TPHP, TCEP TCIPP congeners/compounds. Most studies showed predominance moderate bias, global strength low. The limitations here reviewed, hazardous effects herein identified highlights need good quality large-scale cohort which biomarkers should be quantified biological samples.

Language: Английский

Citations

2