Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 9, 2024
The
composition
of
the
gut
microbiome
differs
from
that
healthy
individuals
and
is
closely
linked
to
progression
development
breast
cancer.
Recent
studies
have
increasingly
examined
relationship
between
microbial
communities
This
study
analyzed
research
landscape
cancer,
focusing
on
736
qualified
publications
Web
Science
Core
Collection
(WoSCC).
Publications
in
this
field
are
rise,
with
United
States
leading
contributions,
followed
by
China
Italy.
Despite
strong
output,
centrality
value
comparatively
low
at
ninth,
highlighting
a
gap
quantity
its
global
impact.
pattern
repetitively
observed
institutional
predominance
Western
institutes
among
top
contributors,
underscoring
potential
quality
China.
Keyword
analysis
reveals
hotspots
focused
effect
cancer
pathogenesis
tumor
metabolism,
risk
factors
metabolic
pathways
being
most
interesting
areas.
point
shift
toward
anti-tumor
therapies
personalized
medicine,
clusters
such
as
"anti-tumor"
"potential
regulatory
agent"
gaining
prominence.
Additionally,
intratumor
bacteria
emerged
new
area
significant
interest,
reflecting
direction
research.
University
Helsinki
Adlercreutz
H
influential
institutions
researchers
field.
Current
trends
indicate
therapeutic
applications
medicine.
Strengthening
international
collaborations
crucial
for
advancing
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: July 29, 2024
Human
exposure
to
heavy
metals,
which
encompasses
both
essential
and
toxic
varieties,
is
widespread.
The
intestine
functions
as
a
critical
organ
for
absorption
metabolism
of
metals.
Gut
microbiota
plays
crucial
role
in
metal
absorption,
metabolism,
related
processes.
Toxic
metals
(THMs),
such
arsenic
(As),
mercury
(Hg),
lead
(Pb),
cadmium
(Cd),
can
cause
damage
multiple
organs
even
at
low
levels
exposure,
it
emphasize
their
potential
high
toxicity.
Nevertheless,
certain
trace
elements,
including
iron
(Fe),
copper
(Cu),
manganese
(Mn),
play
vital
roles
the
biochemical
physiological
organisms
concentrations
but
exert
effects
on
gut
higher
levels.
Some
potentially
micronutrients,
chromium
(Cr),
silicon
(Si),
nickel
(Ni),
were
considered
be
intermediate
terms
essentiality
toxicity,
had
different
metabolites.
Bidirectional
relationships
between
have
been
found.
Heavy
disrupts
influences
its
functions,
contributing
metabolic
other
disorders.
Furthermore,
by
serving
physical
barrier
against
modulating
pH,
oxidative
balance,
detoxification
enzymes
or
proteins
involved
metabolism.
interactions
might
positive
negative
according
valence
states,
concentrations,
forms
same
metal.
This
paper
reviews
10
common
with
health
implications.
collated
information
could
provide
novel
insights
into
disruption
intestinal
caused
factor
human
diseases.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(30)
Published: June 5, 2024
Cadmium
(Cd)
is
a
neurotoxic
contaminant
that
induces
cognitive
decline
similar
to
observed
in
Alzheimer's
disease
(AD).
Autophagic
flux
dysfunction
attributed
the
pathogenesis
of
AD,
and
this
study
aimed
investigate
effect
autophagy
on
environmental
Cd-induced
AD
progression
underlying
mechanism.
Here,
Cd
exposure
inhibited
autophagosome-lysosome
fusion
impaired
lysosomal
function,
leading
defects
autophagic
clearance
then
APP
accumulation
nerve
cell
death.
Proteomic
analysis
coupled
with
Ingenuity
Pathway
Analysis
(IPA)
identified
SIRT5
as
an
essential
molecular
target
Cd-impaired
flux.
Mechanistically,
hampered
expression
SIRT5,
thus
increasing
succinylation
RAB7A
at
lysine
31
inhibiting
activity,
which
contributed
blockade.
Importantly,
overexpression
led
restoration
blockade,
alleviation
Aβ
deposition
memory
deficits,
desuccinylation
Cd-exposed
FAD
Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(3)
Published: March 1, 2025
ABSTRACT
Despite
being
classified
as
neurodevelopmental
disorders,
in
recent
years,
there
has
been
a
growing
interest
the
association
between
autism
spectrum
disorders
(ASDs)
and
gut
pathology.
This
comprehensive
systematic
review
explores
potential
mechanism
underlying
pathology
ASDs,
including
alterations
microbiota,
intestinal
permeability,
immune
dysregulation,
gastrointestinal
(GI)
symptoms.
Specifically,
it
delves
into
role
of
toxic
essential
metals
their
interplay,
affecting
development
function
GI
tract.
The
also
discusses
implications
this
management
ASDs.
Studies
have
shown
that
heavy
metal
exposure,
whether
through
environmental
sources
or
dietary
intake,
can
disrupt
delicate
balance
trace
elements
gut.
disruption
adversely
affect
zinc
homeostasis,
potentially
exacerbating
individuals
with
impaired
absorption
resulting
from
exposure
may
contribute
to
oxidative
stress,
inflammation
observed
By
shedding
light
on
multifaceted
nature
pathology,
impact
dyshomeostasis
non‐genetic
factor
ASD,
underscores
significance
gut‐brain
axis
etiology
image
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(3), P. 188 - 188
Published: March 14, 2025
This
study
provides
a
comprehensive
analysis
of
the
complex
interaction
between
heavy
metals
(HMs)
and
gut
microbiota,
adopting
bidirectional
approach
that
explores
both
influence
HMs
on
microbiota
populations
potential
role
probiotics
in
modulating
these
changes.
By
examining
interconnected
aspects,
aims
to
offer
deeper
understanding
how
disrupt
microbial
balance
probiotic
interventions
may
mitigate
or
reverse
effects,
promoting
detoxification
processes
overall
health.
In
addition,
review
highlights
innovative
tools,
such
as
biosensors,
for
rapid,
precise,
non-invasive
detection
urine.
These
advanced
technologies
enable
real-time
monitoring
effectiveness
probiotic-based
interventions,
offering
critical
insights
into
their
elimination
from
body
improving
detoxification.
