Effects of pesticides on fish: An overview of evolution of bioassays and cutting edge technologies DOI
Rajib Majumder

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Combined exposure of emamectin benzoate and microplastics induces tight junction disorder, immune disorder and inflammation in carp midgut via lysosome/ROS/ferroptosis pathway DOI
Xu Shi,

Tong Xu,

Meichen Gao

et al.

Water Research, Journal Year: 2024, Volume and Issue: 257, P. 121660 - 121660

Published: April 22, 2024

Language: Английский

Citations

46
Epicatechin attenuates emamectin benzoate-induced liver injury in grass carp by activating Nrf2/GPX4 signaling pathway DOI
Xinhui Zhang, Fengyan Zhang,

Musen Li

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: 157, P. 110118 - 110118

Published: Jan. 12, 2025

Language: Английский

Citations

1
Investigation of the Mechanisms of Liver Injury Induced by Emamectin Benzoate Exposure at Environmental Concentrations in Zebrafish: A Multi-Omics Approach to Explore the Role of the Gut-Liver Axis DOI
Jie Gu,

Yuehong Shen,

Liguo Guo

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138008 - 138008

Published: March 1, 2025

Language: Английский

Citations

1
Emamectin benzoate exposure induced carp kidney injury by triggering mitochondrial oxidative stress to accelerate ferroptosis and autophagy DOI
Li Lü, Wan Li, Yufeng Liu

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 203, P. 106017 - 106017

Published: July 6, 2024

Language: Английский

Citations

6
New insights into resveratrol attenuates hepatotoxicity in emamectin benzoate-exposed grass carp (Ctenopharyngodon idella) via NO system/NF-κB signaling pathway DOI

Yanju Bi,

Haidong Wei, Tingting Yu

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 202, P. 105941 - 105941

Published: May 3, 2024

Language: Английский

Citations

5
Investigate the binding of pesticides with the TLR4 receptor protein found in mammals and zebrafish using molecular docking and molecular dynamics simulations DOI Creative Commons
Sandeep Yadav, M. Aslam,

Ayushi Prajapat

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 18, 2024

The widespread use of pesticides poses significant threats to both environmental and human health, primarily due their potential toxic effects. study investigated the cardiovascular toxicity selected pesticides, focusing on interactions with Toll-like receptor 4 (TLR4), an important part innate immune system. Using computational tools such as molecular docking, dynamics (MD) simulations, principal component analysis (PCA), density functional theory (DFT) calculations, ADME analysis, this identified C160 having lowest binding affinity (-8.2 kcal/mol), followed by C107 C165 (-8.0 kcal/mol). RMSD, RMSF, Rg, hydrogen bond metrics indicated formation stable complexes between specific TLR4. PCA revealed structural changes upon ligand binding, affecting stability flexibility, while DFT calculations provided information about stability, reactivity, polarity compounds. studies highlighted solubility, permeability, metabolic C107, C160, C165, suggesting for bioavailability impact toxicity. exhibit higher bioactivity scores, indicating favourable absorption, metabolism, distribution properties. also violated rule where weight is greater than 500 g/mol. Further, NCI post MD conformations confirmed ligands at pocket. shed light mechanisms pesticide-induced toxicity, aiding in development strategies mitigate harmful effects health.

Language: Английский

Citations

5
Proteomic and cardiac dysregulation by representative perfluoroalkyl acids of different chemical speciation during early embryogenesis of zebrafish DOI
Jing Li, Chenyan Hu, Bin Zhao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 172000 - 172000

Published: March 27, 2024

Language: Английский

Citations

4
Trace-level Gabapentin can induce cardiovascular developmental toxicity through apoptosis in zebrafish larvae DOI
Yide He, Jun Hu, Rosa Freitas

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 358, P. 124526 - 124526

Published: July 9, 2024

Language: Английский

Citations

4
A Novel Framework for Industrial Pesticide Effluent Assessment: Integrating Chemical Screening, Multi-endpoint Responses and Literature-based Validation DOI

Jie Gu,

Yiwen Luo,

Mengyuan Liang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137830 - 137830

Published: March 5, 2025

Language: Английский

Citations

0
Neomycin affects cardiovascular and hematopoietic system via the PI3K/Akt pathway in zebrafish larvae DOI
Yuan Lin, Qiuping Zhang,

Lu Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118203 - 118203

Published: April 21, 2025

Language: Английский

Citations

0