Medical Research Archives,
Journal Year:
2023,
Volume and Issue:
11(12)
Published: Jan. 1, 2023
Background:
This
perspective
concerning
hepatoxicity
of
per-
and
polyfluoroalkyl
substances
(PFAS)
aims
to
provide
a
current
understanding
the
damage
reasonable
clinician
responses
needs
concerned
patients
affected
communities.
Methods:
Search
strategy
included
PFAS
following:
human
liver
toxicity/disease;
relevant
biomarkers
including
transaminases,
lipids,
uric
acid;
predictive
equations
(for
disease),
imaging
modalities,
histologic
findings.
Experimental
data
outcomes
disrupted
hepatic
metabolic
pathways
was
also
reviewed.
Recommended
clinical
approaches
communities
sought
in
both
National
Library
Medicine
organizational
websites.
Results:
Several
reliably
cause
adverse
changes
biomarkers,
with
strong
consistency
between
experimental
data.
Adverse
population
include
cholesterol
LDL
cholesterol,
acid.
biomarker
triad
suggests
that
mechanisms
are
or
resemble
associated
steatotic
disease,
which
is
found
across
species
following
exposure.
Human
studies
sparse
mostly
support
inference
toxicant
resembles
pathway
can
lead
from
steatosis
more
serious
stages
disease
due
metabolism
fatty
acids.
Advice
clinicians
reviewed
various
agencies
nonprofits
organizations
committee
US
Academies
Sciences,
Engineering,
Medicine,
nonprofit/university
collaboration
REACH.
Discussion:
Converging
lines
evidence
indict
as
(and
trans-species)
hepatotoxins
continuum
nature
injury.
Increases
abnormal
transaminases
sparser
biopsy
findings
clinically
important
contributing
public
health
problem.
It
still
challenging
decide
many
definitively
is/are
most
Many
use
remain
virtually
unstudied,
research
emergency.
Simple
concerns
heavily
contaminated
communities,
within
capabilities
offices,
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4443 - 4443
Published: May 23, 2024
Endangered
species
detection
plays
an
important
role
in
biodiversity
conservation
and
is
significant
maintaining
ecological
balance.
Existing
deep
learning-based
object
methods
are
overly
dependent
on
a
large
number
of
supervised
samples,
building
such
endangered
datasets
usually
costly.
Aiming
at
the
problems
faced
by
detection,
as
low
accuracy
easy
loss
location
information,
efficient
method
with
fewer
samples
proposed
to
extend
few-shot
technique
field
which
requires
only
small
training
obtain
excellent
results.
First,
SE-Res2Net
optimize
feature
extraction
capability.
Secondly,
RPN
network
multiple
attention
mechanism
proposed.
Finally,
for
classification
confusion
problem,
weighted
prototype-based
comparison
branch
introduced
construct
category
prototype
vectors,
effectively
improves
performance
original
classifier.
Under
setting
30
dataset,
average
value
method,
mAP50,
reaches
76.54%,
7.98%
higher
than
that
pre-improved
FSCE
method.
This
paper
also
compares
algorithm
PASCOL
VOC
optimal
has
good
generalization
ability
compared
other
five
algorithms.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 14, 2023
Abstract
Per-
and
polyfluoroalkyl
substances
(PFAS)
threaten
human
wildlife
health,
but
their
movement
through
food
webs
remains
poorly
understood.
Contamination
of
the
physical
environment
is
widespread,
particularly
concentrated
at
military
installations.
Here
we
measured
17
PFAS
in
wild,
free-living
mammals
migratory
birds
Holloman
Air
Force
Base
(AFB),
New
Mexico,
USA,
where
wastewater
catchment
lakes
form
biodiverse
oases.
concentrations
were
among
highest
ever
reported
animal
tissues,
high
levels
have
persisted
for
least
three
decades.
The
hazardous
long
carbon-chain
form,
perfluorooctanosulfonic
acid
(PFOS),
was
most
abundant,
with
liver
averaging
tens
thousands
ng/g
wet
weight
(ww),
reaching
as
97,000
(ww)
a
1994
specimen
white-footed
mouse
(
Peromyscus
leucopus
)
38,000
ww
duck,
American
wigeon
Mareca
americana
).
Perfluorohexanesulfonic
(PFHxS)
averaged
livers
house
mice,
one
order
magnitude
lower
upland
desert
rodent
species.
strikingly
control
sites,
even
highly
mobile
Tissue
correlated
within
individuals,
consistently
higher
than
muscle
or
blood.
Twenty
23
vertebrate
species
sampled
AFB
heavily
contaminated,
representing
multiple
trophic
microhabitats,
implicating
range
pathways
spread:
ingestion
surface
water,
sediments,
dust;
foraging
on
aquatic
invertebrates
plants
by
secondary
consumers;
preying
upon
small
vertebrates
level
consumers,
including
consumption
game
hunters.
Unlike
other
systems,
piscivory
not
an
important
pathway
uptake.
In
sum,
legacy
wetland
permeated
local
web
across
period
decades,
severely
contaminating
resident
migrant
animals,
likely
exposing
humans
via
meat
outdoor
recreation.
Five
highlights
A
biodiverse,
base
contaminated
PFAS.
Littoral-zone
mice
had
PFOS,
up
to
ww.
Species
ecological
variation
16
detected
tissues.
Game
dangerously
can
transport
it
distances.
Biorepositories
provide
key
temporal
spatial
sampling
contaminant
studies.
Graphical
abstract
Medical Research Archives,
Journal Year:
2023,
Volume and Issue:
11(12)
Published: Jan. 1, 2023
Background:
This
perspective
concerning
hepatoxicity
of
per-
and
polyfluoroalkyl
substances
(PFAS)
aims
to
provide
a
current
understanding
the
damage
reasonable
clinician
responses
needs
concerned
patients
affected
communities.
Methods:
Search
strategy
included
PFAS
following:
human
liver
toxicity/disease;
relevant
biomarkers
including
transaminases,
lipids,
uric
acid;
predictive
equations
(for
disease),
imaging
modalities,
histologic
findings.
Experimental
data
outcomes
disrupted
hepatic
metabolic
pathways
was
also
reviewed.
Recommended
clinical
approaches
communities
sought
in
both
National
Library
Medicine
organizational
websites.
Results:
Several
reliably
cause
adverse
changes
biomarkers,
with
strong
consistency
between
experimental
data.
Adverse
population
include
cholesterol
LDL
cholesterol,
acid.
biomarker
triad
suggests
that
mechanisms
are
or
resemble
associated
steatotic
disease,
which
is
found
across
species
following
exposure.
Human
studies
sparse
mostly
support
inference
toxicant
resembles
pathway
can
lead
from
steatosis
more
serious
stages
disease
due
metabolism
fatty
acids.
Advice
clinicians
reviewed
various
agencies
nonprofits
organizations
committee
US
Academies
Sciences,
Engineering,
Medicine,
nonprofit/university
collaboration
REACH.
Discussion:
Converging
lines
evidence
indict
as
(and
trans-species)
hepatotoxins
continuum
nature
injury.
Increases
abnormal
transaminases
sparser
biopsy
findings
clinically
important
contributing
public
health
problem.
It
still
challenging
decide
many
definitively
is/are
most
Many
use
remain
virtually
unstudied,
research
emergency.
Simple
concerns
heavily
contaminated
communities,
within
capabilities
offices,