Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses DOI Open Access
Alan Ducatman, Lida Chatzi

Medical Research Archives, Journal Year: 2023, Volume and Issue: 11(12)

Published: Jan. 1, 2023

Background: This perspective concerning hepatoxicity of per- and polyfluoroalkyl substances (PFAS) aims to provide a current understanding the damage reasonable clinician responses needs concerned patients affected communities. Methods: Search strategy included PFAS following: human liver toxicity/disease; relevant biomarkers including transaminases, lipids, uric acid; predictive equations (for disease), imaging modalities, histologic findings. Experimental data outcomes disrupted hepatic metabolic pathways was also reviewed. Recommended clinical approaches communities sought in both National Library Medicine organizational websites. Results: Several reliably cause adverse changes biomarkers, with strong consistency between experimental data. Adverse population include cholesterol LDL cholesterol, acid. biomarker triad suggests that mechanisms are or resemble associated steatotic disease, which is found across species following exposure. Human studies sparse mostly support inference toxicant resembles pathway can lead from steatosis more serious stages disease due metabolism fatty acids. Advice clinicians reviewed various agencies nonprofits organizations committee US Academies Sciences, Engineering, Medicine, nonprofit/university collaboration REACH. Discussion: Converging lines evidence indict as (and trans-species) hepatotoxins continuum nature injury. Increases abnormal transaminases sparser biopsy findings clinically important contributing public health problem. It still challenging decide many definitively is/are most Many use remain virtually unstudied, research emergency. Simple concerns heavily contaminated communities, within capabilities offices,

Language: Английский

Per- and polyfluoroalkyl substances in livers of wild boar (Sus scrofa) in Germany: analysis of official monitoring data in relation to local land use characteristics DOI Creative Commons
Rafael Hernán Mateus-Vargas, Jorge Numata, Anneluise Mader

et al.

Journal of Consumer Protection and Food Safety, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0

Detection of PFAS in sugarbushes across the Ceded Territories: a method for PFAS analysis in maple sap and syrup DOI

Eve Milusich,

Emily Cornelius Ruhs,

Jonathan Gilbert

et al.

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

Citations

0

Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review DOI
Lorena Oliveira Souza Soares, Gabriel de Farias Araújo,

Thais Braga Gomes

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 977, P. 179395 - 179395

Published: April 16, 2025

Language: Английский

Citations

0

A Few-Shot Object Detection Method for Endangered Species DOI Creative Commons
Hongmei Yan,

Xiaoman Ruan,

Daixian Zhu

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4443 - 4443

Published: May 23, 2024

Endangered species detection plays an important role in biodiversity conservation and is significant maintaining ecological balance. Existing deep learning-based object methods are overly dependent on a large number of supervised samples, building such endangered datasets usually costly. Aiming at the problems faced by detection, as low accuracy easy loss location information, efficient method with fewer samples proposed to extend few-shot technique field which requires only small training obtain excellent results. First, SE-Res2Net optimize feature extraction capability. Secondly, RPN network multiple attention mechanism proposed. Finally, for classification confusion problem, weighted prototype-based comparison branch introduced construct category prototype vectors, effectively improves performance original classifier. Under setting 30 dataset, average value method, mAP50, reaches 76.54%, 7.98% higher than that pre-improved FSCE method. This paper also compares algorithm PASCOL VOC optimal has good generalization ability compared other five algorithms.

Language: Английский

Citations

0

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: multiple pathways for wildlife and human exposure DOI Creative Commons
Christopher C. Witt, Chauncey R. Gadek, Jean‐Luc E. Cartron

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 14, 2023

Abstract Per- and polyfluoroalkyl substances (PFAS) threaten human wildlife health, but their movement through food webs remains poorly understood. Contamination of the physical environment is widespread, particularly concentrated at military installations. Here we measured 17 PFAS in wild, free-living mammals migratory birds Holloman Air Force Base (AFB), New Mexico, USA, where wastewater catchment lakes form biodiverse oases. concentrations were among highest ever reported animal tissues, high levels have persisted for least three decades. The hazardous long carbon-chain form, perfluorooctanosulfonic acid (PFOS), was most abundant, with liver averaging tens thousands ng/g wet weight (ww), reaching as 97,000 (ww) a 1994 specimen white-footed mouse ( Peromyscus leucopus ) 38,000 ww duck, American wigeon Mareca americana ). Perfluorohexanesulfonic (PFHxS) averaged livers house mice, one order magnitude lower upland desert rodent species. strikingly control sites, even highly mobile Tissue correlated within individuals, consistently higher than muscle or blood. Twenty 23 vertebrate species sampled AFB heavily contaminated, representing multiple trophic microhabitats, implicating range pathways spread: ingestion surface water, sediments, dust; foraging on aquatic invertebrates plants by secondary consumers; preying upon small vertebrates level consumers, including consumption game hunters. Unlike other systems, piscivory not an important pathway uptake. In sum, legacy wetland permeated local web across period decades, severely contaminating resident migrant animals, likely exposing humans via meat outdoor recreation. Five highlights A biodiverse, base contaminated PFAS. Littoral-zone mice had PFOS, up to ww. Species ecological variation 16 detected tissues. Game dangerously can transport it distances. Biorepositories provide key temporal spatial sampling contaminant studies. Graphical abstract

Language: Английский

Citations

0

Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses DOI Open Access
Alan Ducatman, Lida Chatzi

Medical Research Archives, Journal Year: 2023, Volume and Issue: 11(12)

Published: Jan. 1, 2023

Background: This perspective concerning hepatoxicity of per- and polyfluoroalkyl substances (PFAS) aims to provide a current understanding the damage reasonable clinician responses needs concerned patients affected communities. Methods: Search strategy included PFAS following: human liver toxicity/disease; relevant biomarkers including transaminases, lipids, uric acid; predictive equations (for disease), imaging modalities, histologic findings. Experimental data outcomes disrupted hepatic metabolic pathways was also reviewed. Recommended clinical approaches communities sought in both National Library Medicine organizational websites. Results: Several reliably cause adverse changes biomarkers, with strong consistency between experimental data. Adverse population include cholesterol LDL cholesterol, acid. biomarker triad suggests that mechanisms are or resemble associated steatotic disease, which is found across species following exposure. Human studies sparse mostly support inference toxicant resembles pathway can lead from steatosis more serious stages disease due metabolism fatty acids. Advice clinicians reviewed various agencies nonprofits organizations committee US Academies Sciences, Engineering, Medicine, nonprofit/university collaboration REACH. Discussion: Converging lines evidence indict as (and trans-species) hepatotoxins continuum nature injury. Increases abnormal transaminases sparser biopsy findings clinically important contributing public health problem. It still challenging decide many definitively is/are most Many use remain virtually unstudied, research emergency. Simple concerns heavily contaminated communities, within capabilities offices,

Language: Английский

Citations

0