Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway DOI Creative Commons
Hui Shen,

hongxia li,

wenlan pan

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 14, 2023

Abstract Background: Heat exposure is an environmental stressor that has been associated with cognitive impairment. However, the neural mechanisms underlie this phenomenon have yet to be extensively investigated. Methods: The Morris water maze test was utilized assess performance. RNA sequencing employed discover primary regulators and pathological pathways involved in impairment caused by heat. Prior heat vivo vitro, activation of sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) achieved CDN1163. Hematoxylin-Eosin, Nissl staining, imaging, transmission electron microscopy, western blot immunofluorescence were visualize histological changes, intracellular levels, endoplasmic stress (ERS) markers, apoptosis, synaptic proteins alterations. Results: (HS) significantly induced decline neuronal damage mice. By transcriptome between control (n=5) mice hippocampal tissues, we identified a reduction expression atp2a gene encoding SERCA, accompanied corresponding decrease its protein level. Consequently, dysregulation resulted excessive accumulation ions. Furthermore, HS also activated ERS as evidenced upregulation p-PERK, p-eIF2α, CHOP caspase 3. Consistently, postsynaptic density 95 (PSD95) synaptophysin (SYN) expressions indicated modifications function. Notably, impacts on neurons found mitigated CDN1163 treatment both vitro. Additionally, SERCA-mediated apoptosis attenuated GSK2606414 via inhibiting PERK-eIF2α-CHOP axis not only curtailed level 3, but elevated levels PSD95 SYN. Conclusions: These findings highlight significant impact impairment, further elucidate underlying mechanism involving SERCA/PERK/eIF2α pathway.

Language: Английский

Bisphenol mixtures, metal mixtures and type 2 diabetes mellitus: Insights from metabolite profiling DOI Creative Commons

Ze Yang,

Hongbo Liu,

Jiemin Wei

et al.

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108921 - 108921

Published: July 30, 2024

Little is known about the combined effect of bisphenol mixtures and metal on type 2 diabetes mellitus (T2DM) risk, mediating roles metabolites. The study included 606 pairs T2DM cases controls matched by age sex, information participants was collected through questionnaires laboratory tests. Serum plasma concentrations were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) inductively coupled plasma-mass (ICP-MS), respectively. Widely targeted metabolomics employed to obtain serum metabolomic profiles. Conditional logistic regression models used assess single associations bisphenols metals with risk after multivariable adjustment. Additionally, joint effects examined quantile-based g-computation (QG-C) models. Furthermore, differential metabolites associated identified, mediation analyses performed explore role in risk. results showed an increased A (BPA) identified as primary contributor. While association between remained inconclusive, cobalt (Co), iron (Fe), zinc (Zn) highest weight indices for total 154 screened controls. Mediation indicated that 9 mediated BPA T2DM, while L-valine Zn BPA, Co, Fe, contributors played a T2DM. Our findings contribute better understanding mechanisms underlying

Language: Английский

Citations

2

Impacts of school environment quality on autistic pupil's behaviours – A systematic review DOI Creative Commons

Rahaf Al Qutub,

Zhiwen Luo, Carolina Vasilikou

et al.

Building and Environment, Journal Year: 2024, Volume and Issue: 265, P. 111981 - 111981

Published: Aug. 16, 2024

Language: Английский

Citations

2

Response of surface energy components to urban heatwaves and its impact on human comfort in coastal city DOI
Yizhao Wei, Han Chen, Jinhui Jeanne Huang‬‬‬‬

et al.

Urban Climate, Journal Year: 2024, Volume and Issue: 54, P. 101836 - 101836

Published: March 1, 2024

Language: Английский

Citations

1

Climate Change and Aging: Implications for Psychiatric Care DOI Creative Commons

Michelle M. Mehta,

Anne E. Johnson, Badr Ratnakaran

et al.

Current Psychiatry Reports, Journal Year: 2024, Volume and Issue: 26(10), P. 499 - 513

Published: Aug. 30, 2024

We reviewed recent evidence regarding the impact of climate change (specifically, high ambient temperatures, heatwaves, weather-related disasters, and air pollution) on older adults' mental health. also summarized other medical problems that can occur in aging adults connection with change, resulting psychiatric manifestations or influencing psychopharmacological management.

Language: Английский

Citations

1

Heatwaves and its impact on the depressive symptoms among Chinese community-dwelling older adults: examining the role of social participation DOI
Boye Fang,

Qi Zhang

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 129, P. 105668 - 105668

Published: Oct. 22, 2024

Language: Английский

Citations

1

Cognitive decline in relation to later-life high temperature exposure in a Chinese nationwide cohort DOI Creative Commons
Yuqian Huang, Liansheng Zhang,

Jixing Yang

et al.

Advances in Climate Change Research, Journal Year: 2024, Volume and Issue: 15(6), P. 1078 - 1087

Published: Nov. 16, 2024

Language: Английский

Citations

1

Effects of ambient temperature on mental and neurological conditions in older adults: A systematic review and meta-analysis DOI Creative Commons
Garam Byun, Yongsoo Choi, Damien Foo

et al.

Environment International, Journal Year: 2024, Volume and Issue: 194, P. 109166 - 109166

Published: Nov. 23, 2024

Language: Английский

Citations

1

Increasing ambient temperature disrupts sleep and impairs cognitive function among Older Adults DOI Creative Commons
Godfred O. Boateng, Gabriel John Dusing,

Shaira Shafiquzzaman

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 27, 2024

Abstract Increases in ambient temperature have been associated with deleterious consequences for socially disadvantaged populations. However, there is limited research on the mental health effects. Thus, this study examined direct and indirect effects of high temperatures sleep quality cognitive function among older adults. Using combined data from WHO Ghana Study Global Ageing Adult Health measurements derived Climatic Research Unit gridded Time Series structural equation models, we relationship between increasing mean temperatures, difficulties, impairment while adjusting appropriate covariates. change were an increase severity difficulties a decrease function. The effect significantly increased females adults (65+). Our shows that reduction will improve enhance

Language: Английский

Citations

0

Urban and Rural Environments and Their Implications for Older Adults’ Adaptation to Heat Waves: A Systematic Review DOI Creative Commons
Pablo De Gea Grela, Diego Sánchez González, Lorena Gallardo-Peralta

et al.

Land, Journal Year: 2024, Volume and Issue: 13(9), P. 1378 - 1378

Published: Aug. 28, 2024

The aim of this study is to synthesise the scientific evidence on implications urban and rural environments older adults’ adaptation strategies heatwaves. Methods: methodology follows PRISMA guidelines, which involves a systematic search literature in selected electronic databases, including Web Science Scopus, assist selection, identification retention studies. Results: identified 4991 potentially eligible articles, 17 met criteria, mainly from developed countries, emphasising multidisciplinary approach moderate low quality. Urban influence heatwaves through adequacy physical environment dwelling (design, materials, equipment) neighbourhood (green spaces, residential density, land use), social (support network type assistance) risk management (protective measures heat warning systems). At individual level, determined by age, gender, health status, socio-economic status isolation. Discussion conclusions: Differences perceptions were found according location, typology environmental characteristics, especially developing countries. findings contribute promoting adoption protective measures, design systems, planning friendly resilient cities communities support an ageing society climate warming.

Language: Английский

Citations

0

The combined effects of heatwaves, air pollution and greenery on the risk of frailty: a national cohort study DOI Creative Commons

Weifang Dai,

Shanna Liu, Weina Xu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 16, 2024

The associations between heatwaves and frailty, as well the joint effects of with air pollution greenery, are currently unknown. This study leverages data from China Health Retirement Longitudinal Study (CHARLS), which collected information 6,400 older adults 2011 2018. Our outcome variable was measured by frailty index (FI > 0.21). Heatwaves were defined based on maximum temperature, incorporating four thresholds (≥ 97.5%, 92.5%, 90%) three durations 2, 3, 4 days). These variables considered time-varying variables, representing one-year exposure preceding survival events. Fine particulate matter (PM2.5) greenery (normalized difference vegetation (NDVI)) utilized indicators exposure, respectively, treated concurrent heatwaves.Time-varying Cox proportional hazards models employed to assess independent effects, multiplicative additive interactions heatwaves, pollution, risk frailty. quantified using hazard ratios (HRs), a traditional product term ratio HRs, relative excess due interaction (RERI). findings indicate that associated an increased HRs ranging 1.035 (95% CI: 1.006-1.064) 1.063 1.028-1.101). We observed both positive (HRs 1) (RERI 0) high level PM

Language: Английский

Citations

0