Exposure to perfluorodecanoic acid impairs follicular development via inducing granulosa cell necroptosis DOI Creative Commons
Zekun Liu, Zhenyan Cui,

Chunming Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 287, P. 117268 - 117268

Published: Nov. 1, 2024

Per- and polyfluoroalkyl substances (PFAS) have attracted significant attention due to their environmental toxicity. However, the detrimental impact of PFAS on development female reproductive system remains controversial. In this study, we investigated effects three specific compounds perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA), perfluorodecanoic (PFDA) ovarian development. Among these compounds, PFDA demonstrated most pronounced cytotoxic effect granulosa cells. The results showed that a 200 μM concentration induced cell apoptosis via intrinsic pathway by elevating reactive oxygen species (ROS) levels activating Caspase-9 Caspase-3. Furthermore, triggered necroptosis, form regulated death (RCD), through receptor-interacting serine/threonine kinase 1 (RIPK1), receptor interacting protein 3 (RIPK3), mixed-lineage domain-like (MLKL) axis, mediated inhibition canonical proteolytic enzyme Caspase-8. vivo experiments confirmed mice exposed displayed significantly reduced index compared control group, accompanied evident follicular atresia. Ovarian tissues from PFDA-exposed group upregulated necroptosis markers, which were effectively mitigated inhibiting phosphorylation RIPK1 at Ser166. Importantly, study provides first evidence disrupts novel mechanism involving RIPK1-mediated pathway, alongside detection pathway. This greatly expands our insight into death. finding highlights potential public health hazards associated with exposure emphasizes need for further research fully understand its broader implications.

Language: Английский

An Introduction to Marine Ecosystem: Environmental and Economic Impacts DOI
Naima Hamid,

Thodhal Yoganandham Suman

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pretreatment and detection of per- and polyfluoroalkyl substances (PFAS): A review of current advancements, development challenges, and perspectives DOI
Shiya Li, Qinglong Wang, L. H. Lyu

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113789 - 113789

Published: April 1, 2025

Language: Английский

Citations

0
Spatial distribution, trophic magnification, and risk assessment of per- and polyfluoroalkyl substances in Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis): Risks of emerging alternatives DOI
Shuai Liu,

Yu Liu,

Bin Tang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135246 - 135246

Published: July 17, 2024

Language: Английский

Citations

3
A FAIR comparison of activated carbon, biochar, cyclodextrins, polymers, resins, and metal organic frameworks for the adsorption of per- and polyfluorinated substances DOI Creative Commons
Navid Saeidi, Adelene Lai, Falk Harnisch

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155456 - 155456

Published: Sept. 3, 2024

Per- and polyfluorinated substances (PFAS) have complex sorption behaviors, complicating removal from water selection of suitable adsorbents. We evaluated adsorption 44 PFAS across four adsorbent groups: activated carbon biochar (AC BC), cyclodextrin-based adsorbents (cyclodextrins), polymer-based resins, inorganic metal organic frameworks (MOFs). analyzed over 500 coefficients (Kd) literature, calculated at aqueous equilibrium concentration 1 ± 0.3 µg/L under comparable experimental conditions. On average, Kd AC BC exceeded 107 L/kg for with C-F bonds > 7, unlike other < 107. This trend holds 4. Cyclodextrins, resins outperform ≤ For BC, follows the order PFOS>PFOA>PFBS>PFBA, increasing point zero charge. as well cyclodextrin, values were related to hydrophobicity steric properties. Additionally, was influenced by head group type, non-fluorinated atoms, presence oxygen and/or chlorine in PFAS. No clear relationship found Adsorption prediction using a Random Forest Regressor literature data feasible but not Cyclodextrins removing varying mobilities water, whereas are superior low mobility To support further use all code used freely available, following FAIR principles.

Language: Английский

Citations

3
Electrospun superhydrophobic polyvinyl chloride /polydimethylsiloxane-nanodiamond nanocomposite with enhanced antifouling and mechanical properties for fresh produce packaging DOI Creative Commons
Shuhao Liu, Monica Iepure, Wentao Zhou

et al.

Applied Food Research, Journal Year: 2024, Volume and Issue: 4(1), P. 100417 - 100417

Published: April 14, 2024

Food package films serve the important functions of preserving food quality, extending shelf life, and protecting against external contaminants while also providing a barrier to moisture oxygen. In consideration increasing frequency foodborne outbreaks, there is growing demand for packaging with additional functionality prevent cross-contamination attachment pathogens, thereby enhancing bacterial safety. Herein, we report one-step fabrication approach relying on electrospinning blend polyvinyl chloride (PVC) polydimethylsiloxane (PDMS) together nanodiamond (ND) rotating drum collector formation bacterially antifouling films. this approach, by adjusting concentrations PVC, PDMS, ND angular velocity, nanofiber diameter could be tuned in range 0.4 μm 2.0 μm. Furthermore, these process parameters used modulate water contact angle resultant films, minimum 136.2 ± 5.6° maximum 159.5 3.8°. The lowest angles were observed bare PVC fibers highest seen nanocomposite containing PVC/PDMS. Compared ND-PVC/PDMS achieved up 99.8% 99.6% reduction adhesion Salmonella Typhimurium LT2 Listeria innocua, respectively. tensile strength nanofibrous film can increased from 1.2 MPa 4.4 0.3 inclusion PDMS (1:1 wt.%) further 8.9 (PVC/PDMS/ND 1:1:0.1 wt.%). Considering notable properties bacteria improved mechanical characteristics, represent noteworthy step development sustainable active solutions safer healthier supply chain.

Language: Английский

Citations

2
Three-Dimensional Modeling of Anion Exchange Membrane Electrolysis: A Two-Phase Flow Approach DOI Creative Commons
Erwan Tardy, Yann Bultel, Florence Druart

et al.

Energies, Journal Year: 2024, Volume and Issue: 17(13), P. 3238 - 3238

Published: July 1, 2024

Anion exchange membrane water electrolyzers (AEMWEs) are attracting growing interest as a green hydrogen production technology. Unlike proton (PEM) systems, AEMWEs operate in an alkaline environment, allowing one to use less expensive, non-noble materials catalysts for the reactions and non-fluorinated anion polymer membranes. However, performance stability of strongly depend on electrolyte concentration. In this work, three-dimensional multi-physics model considering two-phase flow effects is applied understand impact KOH concentration its rate AEMWE performance, well current gas volume fraction distributions. The numerical results were compared experimental data published literature. For densities above 1 A/cm2, non-uniform H2 O2 distribution could be evidenced by 3D simulations. Increasing from 10 100 mL/min noticeably improves cell A/cm2. These show importance accounting geometry accurately describe operation performance.

Language: Английский

Citations

2
Mechanisms of colon toxicity induced by long-term perfluorooctanoic acid exposure in mice DOI Creative Commons

Xiannan Meng,

Wei Li,

Yongjing Qian

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116762 - 116762

Published: July 23, 2024

Language: Английский

Citations

2
Systematic Assessment of Mechanisms, Developments, Innovative Solutions, and Future Perspectives of Microplastics and Ecotoxicity – A Review DOI Open Access

S. Manikandan,

B. Preethi,

S. Deena

et al.

Advanced Sustainable Systems, Journal Year: 2024, Volume and Issue: 8(11)

Published: July 29, 2024

Abstract As plastics become more ubiquitous, their impact on the environment and human health cannot be overlooked. Once generated, micro‐ nano‐plastics end‐up in environment, causing widespread environmental risks. This is a significant problem given minuscule sizes of microplastics, therefore warrants further investigation. study presents comprehensive review ecotoxicology microplastics methods for degradation decomposition besides discussing fate transport processes, recent progress, emerging strategies, challenges potential future directions. The authors carefully evaluate processes through which cause harm, from molecular interactions species, to ecological impacts, end with advances microplastic biodegradation. Different kinds found include polyethylene, polystyrene, polypropylene, polyvinyl chloride, polycarbonate, polyurethane, polyethylene terephthalate. Analysis microbial enzymatic provides several swelling mitigation strategies designed reduce threats. In‐depth investigations ecotoxicity biodegradation are being facilitated by interdisciplinary proposals areas nanotechnology, new analytical methods, synthetic biology. extensive helps understand comprehensively in‐turn ensures informed actions mitigate challenge sustainable future.

Language: Английский

Citations

2
Per- and polyfluoroalkyl substances (PFAS) in Indian environment: Prevalence, impacts and solutions DOI

G.V. Koulini,

Vignesh Vinayagam,

Indumathi M. Nambi

et al.

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 66, P. 105988 - 105988

Published: Aug. 30, 2024

Language: Английский

Citations

2
Role of per- and polyfluoroalkyl substances in the cardiorenal system: Unraveling crosstalk from the network of pollutants and phenotypes DOI
Ming Yang, Jiaxin Zhao,

Ziwen An

et al.

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 150, P. 116 - 133

Published: March 21, 2024

Language: Английский

Citations

1