Identification of Functional Ncrnas in the Liver Reveals a Novel Regulatory Mechanism Associated with the Dynamic Balance of Growth and Reproduction in Cynoglossus Semilaevis DOI

Kewen Yan,

Bao Shi,

Hanliang Cheng

et al.

Published: Jan. 1, 2024

Language: Английский

The Global Decline in Human Fertility: The Post-Transition Trap Hypothesis DOI Creative Commons
R. John Aitken

Life, Journal Year: 2024, Volume and Issue: 14(3), P. 369 - 369

Published: March 11, 2024

Over the past half a century many countries have witnessed rapid fall in total fertility rates, particularly world's most advanced economies including industrial powerhouses of Eastern Asia and Europe. Such nations now passed through first second demographic transitions are currently exhibiting rates well below replacement threshold 2.1, with no sign recovery. This paper examines factors responsible for driving these considers their impact on both fecundity (our fundamental capacity to reproduce). I argue that because transition was extremely largely driven by socioeconomic factors, it has had lasting genetic/epigenetic underpinnings human fecundity. However, will be different. A series conditions associated low societies, relaxed selection pressure high-fertility genotypes, indiscriminate use assisted reproductive technologies treat infertility, environmental contamination toxicants, may our genetic constitution ways compromise future species. Since any change foundations reproduction difficult reverse, we should actively pursue methods monitor fecundity, as sub-replacement levels become established across globe.

Language: Английский

Citations

10
Molecularly imprinted photopolymers combined with smartphone-based optical sensing for selective detection of bisphenol A in foods DOI
Dounia Elfadil, Aziz Amine

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(10), P. 2479 - 2492

Published: March 11, 2024

Language: Английский

Citations

6
Reproductive toxic effects of chronic exposure to bisphenol A and its analogues in marine medaka (Oryzias melastigma) DOI
Zuchun Chen, Xueyou Li,

Jiahao Gao

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 271, P. 106927 - 106927

Published: April 17, 2024

Language: Английский

Citations

5
Unravelling bisphenol A-induced hepatotoxicity: Insights into oxidative stress, inflammation, and energy dysregulation DOI
Sriparna Das,

Urmi Mukherjee,

Subhasri Biswas

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 124922 - 124922

Published: Sept. 1, 2024

Language: Английский

Citations

4
Gestational exposure to PNMC reduces offspring gamete numbers by disrupting oocyte meiosis and spermatogenesis DOI Creative Commons

Tian Ma,

Hui Yu, Xinyu Zhou

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117980 - 117980

Published: March 1, 2025

3-Methyl-4-nitrophenol (PNMC) is a prevalent nitrophenolic endocrine disruptor found in pregnant women, with known effects on offspring growth and development. However, its impact fertility remains unexplored. This study investigates the of PNMC exposure during pregnancy underlying mechanisms. Our assessments revealed that reduced number follicles spermatozoa offspring, though it did not affect their quality. In male impaired spermatogenesis by reducing Sertoli cells spermatogonia. female disrupted first meiotic prophase (MPI) oocytes, leading to diplotene oocytes available for primordial follicle assembly. depletion reserve ultimately resulted subfertility. Specifically, hindered homologous recombination-mediated DNA double-strand break repair, triggering activation checkpoint MPI arrest. arrested progression oocytes. provide comprehensive evidence reproductive capacity, elucidating key pathways. These findings emphasize need stricter regulatory measures limit offer new insights into etiology idiopathic oligozoospermia diminished ovarian reserve.

Language: Английский

Citations

0
Multi-mechanistic effects of bisphenol A on testicular dysfunction and endocrine disruption in adult male Labeo bata: oxidative stress, inflammation, and dysregulated energy sensors DOI

Urmi Mukherjee,

Soumyajyoti Ghosh,

Sudipta Maitra

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126231 - 126231

Published: April 1, 2025

Language: Английский

Citations

0
Ovarian toxicity of 2,6-di-tert-butyl-hydroxytoluene on female Ruditapes philippinarum: reproductive endocrine disruption and oxidative stress DOI
Xin Zheng, Xiaohui Li,

Ruicheng Qi

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138289 - 138289

Published: April 1, 2025

Language: Английский

Citations

0
Identification of functional ncRNAs in the liver reveals a novel regulatory mechanism associated with the dynamic balance of growth and reproduction in Cynoglossus semilaevis DOI

Kewen Yan,

Bao Shi,

Hanliang Cheng

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742630 - 742630

Published: April 1, 2025

Language: Английский

Citations

0
Bisphenol a Disrupts Steroidogenesis and Induces Apoptosis in Human Granulosa Cells Cultured In Vitro DOI Open Access
Dominika Celar Šturm, Tadeja Režen, Nina Jančar

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4081 - 4081

Published: April 25, 2025

Bisphenol A (BPA) is a common synthetic chemical compound classified as an endocrine disruptor. It affects multiple physiological systems in the body, including female reproductive system, particularly granulosa cells (GCs) ovaries, where steroidogenesis occurs. This study investigated impact of various BPA concentrations (environmentally relevant 0.001 µM and 0.1 toxicological concentration 100 µM) exposure times (24 72 h) on cell viability counts vitro production estradiol progesterone human GCs collected from waste follicular fluid IVF patients. Gene expression analysis 182 genes associated with apoptosis was performed using PCR arrays, followed by protein Western blot. Our results demonstrate that after longer (72 h), higher (100 negatively cellular significantly alters steroid hormone biosynthesis vitro, leading to reduced culture medium. We found all altered different steroidogenesis- apoptosis-related GCs. At μM, decreased TRIM25, UGT2B15, CASP3, RPS6KA3 increased NR6A1 PPID genes. AR, HSD3B1, BID, IKBKG, while reducing TRIM25 CASP3 highest upregulated GPER30, downregulated FOXO1 UGT2B15 These highlight BPA’s concentration-specific effects show its potential compromise GC function, possible negative implications for fertility ovarian health, even at environmentally concentrations.

Language: Английский

Citations

0
The Caenorhabditis elegans neuroendocrine system and their modulators: An overview DOI

Daniela Teixeira Rodrigues,

Heloísa Aiolfi Padilha,

Ana Thalita Gonçalves Soares

et al.

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 586, P. 112191 - 112191

Published: Feb. 20, 2024

Language: Английский

Citations

3