PLoS Genetics,
Journal Year:
2024,
Volume and Issue:
20(10), P. e1011434 - e1011434
Published: Oct. 24, 2024
Benzyl
butyl
phthalate
(BBP),
a
plasticizer
found
in
wide
range
of
consumer
products
including
vinyl
flooring,
carpet
backing,
food
packaging,
personal
care
products,
and
children's
toys,
is
an
endocrine-disrupting
chemical
linked
to
impaired
reproduction
development
humans.
Despite
evidence
that
BBP
exposure
perturbs
the
integrity
male
female
gametes,
its
direct
effect
on
early
meiotic
events
understudied.
Here,
using
nematode
Caenorhabditis
elegans,
we
show
elicits
non-monotonic
dose
response
rate
X-chromosome
nondisjunction
measured
high-throughput
screening
platform.
From
among
doses
tested
(1,
10,
100
500
μM
BBP),
10
elicited
strongest
germline,
resulting
increased
germ
cell
apoptosis
chromosome
organization
defects.
Mass
spectrometry
analysis
shows
C.
elegans
efficiently
metabolizes
into
primary
metabolites,
monobutyl
(MBP)
monobenzyl
(MBzP),
levels
BBP,
MBP,
MBzP
detected
worm
are
within
human
biological
samples.
Exposure
leads
germlines
with
enlarged
mitotic
nuclei,
altered
progression,
activation
p53/CEP-1-dependent
DNA
damage
checkpoint,
double-strand
break
throughout
morphology
defects
oocytes
at
diakinesis,
oxidative
stress.
RNA
sequencing
indicates
results
expression
genes
involved
xenobiotic
metabolic
processes,
extracellular
matrix
organization,
oocyte
morphogenesis,
cycle,
oxidoreduction.
Taken
together,
propose
stress
formation,
thereby
compromising
germline
genomic
segregation.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116023 - 116023
Published: Jan. 30, 2024
An
in
vivo
model
is
necessary
for
toxicology.
This
review
analyzed
the
uses
of
zebrafish
(Danio
rerio)
toxicology
based
on
bibliometrics.
Totally
56,816
publications
about
from
2002
to
2023
were
found
Web
Science
Core
Collection,
with
Toxicology
as
top
6
among
all
disciplines.
Accordingly,
bibliometric
map
reveals
that
"toxicity"
has
become
a
hot
keyword.
It
further
most
common
exposure
types
include
acute,
chronic,
and
combined
exposure.
The
toxicological
effects
behavioral,
intestinal,
cardiovascular,
hepatic,
endocrine
toxicity,
neurotoxicity,
immunotoxicity,
genotoxicity,
reproductive
transgenerational
toxicity.
mechanisms
oxidative
stress,
inflammation,
autophagy,
dysbiosis
gut
microbiota.
toxicants
commonly
evaluated
by
using
nanomaterials,
arsenic,
metals,
bisphenol,
dioxin.
Overall,
provide
unique
well-accepted
investigate
mechanisms.
We
also
discussed
possible
ways
address
some
limitations
model,
such
combination
human
organoids
avoid
species
differences.
Reviews on Environmental Health,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Phthalate
esters
(PAEs)
represent
a
class
of
widely
utilized
plasticizers,
resulting
in
their
pervasive
presence
soil
and
agricultural
crops,
which
poses
significant
risks
to
human
health.
This
review
examines
the
current
state
PAE
pollution,
microbial
resources
available
for
degradation,
associated
degradation
pathways.
It
highlights
advantages
endophytic
bacteria
over
environmental
microorganisms,
including
prolonged
survival
inoculated
strains,
vivo
biodegradation
PAEs,
multifunctional
capabilities.
Furthermore,
mechanisms
by
mitigate
accumulation
across
three
defense
lines
(soil,
body)
are
elucidated.
The
integrated
approach
employing
both
plants
agents
remediation
PAEs
demonstrates
considerable
potential
ensuring
safety
products
safeguarding
work
offers
new
insights
into
addressing
challenges
posed
organic
pollutant
contamination
reducing
body.
