Merging Photoinduced Electron Transfer with Hydrogen Atom Transfer: Formal β-C(sp³)–H Pyridination of Carbonyls

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

In this study, a novel approach that combines photoinduced electron transfer (ET) with hydrogen atom (HAT) has been introduced for the selective β-C(sp3)–H pyridination of carbonyl compounds. This method is notable its absence transition metals and ability to function under benign reaction conditions, resulting in range pyridinated derivatives consistently moderate good yields. The significance technique further underscored by potential late-stage functionalization pharmaceutically significant molecules. Mechanistic investigations confirmed proceeds via radical-mediated pathway.

Language: Английский

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Multicomponent Synthesis of Alkyl BCP-Heteroaryls via Electron Donor–Acceptor Complex Photoactivation under Mild Conditions

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 90(4), P. 1683 - 1696

Published: Jan. 17, 2025

In the vanguard of sustainable chemistry, pursuit efficient pathways for synthesis alkyl bicyclo[1.1.1]pentane-heteroaryls has captured attention scientific vanguard. We herein report a groundbreaking and eco-conscious multicomponent coupling reaction that paves way alkylation heteroarylation [1.1.1]propellane, process uniquely enabled by photochemical prowess an electron donor–acceptor (EDA) complex. This method is distinguished its minimalist yet powerful approach: devoid transition metals, additives, photosensitizers. Its universality further exemplified seamless compatibility broad spectrum halides heteroarenes under standardized conditions, heralding new era synthetic versatility. The method's practicality underscored capacity late-stage modification pharmaceuticals, offering transformative tool enhancement existing drug molecules. Moreover, facile derivatization synthesized products underscores adaptability potential diverse applications. Our mechanistic studies have elucidated underlying radical-relay pathway, pinpointing pivotal role EDA complex in initiating transformation. discovery not only enriches our fundamental understanding but also opens avenues strategic optimization.

Language: Английский

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Visible-Light-Induced Divergent C–H Esterification/Alkylation of Quinoxalin-2(1H)-ones with Aldehydes under Mild Conditions

Organic Letters, Journal Year: 2025, Volume and Issue: 27(10), P. 2526 - 2531

Published: March 5, 2025

Herein, we introduce an efficient and straightforward strategy for the selective C-H esterification alkylation of quinoxalin-2(1H)-ones with aldehydes. A key feature our study is ability to perform both using different types The reaction system highly compatible a range aldehydes, yielding C3-esterified C3-alkylated products in moderate-to-good yields. applicability this approach further enhanced by its scalability through continuous-flow synthesis, late-stage modification significant molecules, product derivatization. Our mechanistic investigations reveal radical relay mechanism, triggered hydrogen atom transfer process.

Language: Английский

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Photoelectrochemical upcycling of PVC plastic waste for the synthesis of chlorinated quinolinone derivatives

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Herein, an environmentally friendly methodology has been established for the photoelectrochemical chlorination of C(sp 2 )–H bonds in quinolinone derivatives using PVC plastic waste as chlorine source.

Language: Английский

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Nitrogen Cycling Dynamics: Investigating Volatilization and its Interplay with N2 Fixation

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(1), P. 17 - 31

Published: Feb. 1, 2024

The nitrogen cycle is the biogeochemical by which converted into multiple chemical forms as it circulates among atmospheric, terrestrial, and marine ecosystems, conversion of can be carried out through both biological physical processes. Important processes in include fixation, ammonification, nitrification, denitrification. majority Earth's atmosphere (78%) atmospheric nitrogen, making largest source nitrogen. However, has limited availability for use, leading to a scarcity usable many types ecosystems. particular interest ecologists because affect rate key ecosystem processes, including primary production decomposition. Human activities such fossil fuel combustion, use artificial fertilizers, release wastewater have dramatically altered global cycle. modification negatively natural environment system also human health. Volatilization its Relationship N2 fascination Nitrogen Cycle agriculture field discuss this paper.

Language: Английский

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Synthesis of Nafimidone Derivatives by Visible-Light-Induced α-C—H Functionalization of Carbonyl

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(2), P. 677 - 677

Published: Jan. 1, 2025

Language: Английский

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A novel macroporous biochar as a biocarrier for DMAC biodegradation: Preparation, performance and mechanism

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112038 - 112038

Published: Jan. 26, 2024

Language: Английский

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A simultaneous impact of digital economy, environment technology, business activity on environment and economic growth in G7: Moderating role of institutions

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32932 - e32932

Published: June 1, 2024

This study investigates the simultaneous influence of digital economy, environmental technologies, business activity, and institutional quality on both environment economic growth in G7 economies from 1996 to 2020. The provides an in-depth analysis investigate quality, particularly regulatory environment, activity. Employing a rigorous methodology encompassing correlation analysis, long-term examination using Driscoll regression estimators, utilization various economy indicators such as internet usage cell subscriptions, we uncover significant insights. findings underscore substantial impact mitigating carbon emissions driving at accelerated rate. Moreover, reveals that certain constraints corporate operations can paradoxically facilitate emission management while also fostering expansion. validates presence inverted U-shaped Environmental Kuznets Curve (EKC) economies. suggests there is specific point which activities start contribute more emissions. highlights importance achieving balance between driven by foreign direct investment goals sustainability. technology becoming increasingly important regulation Significantly, need enhance implementing regulations. It improve adopting superior methods. These are relevant for governments seeking protection. They suggest policy actions accomplish sustainable development goals.

Language: Английский

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Self-catalytic photochemical three-component reaction for the synthesis of multifunctional 3,3-disubstituted oxindoles

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 565, P. 114379 - 114379

Published: July 9, 2024

Language: Английский

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Effect of biochar, graphene, carbon nanotubes, and nanoparticles on microbial denitrification: A review

Critical Reviews in Environmental Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: July 30, 2024

Nitrogen pollution poses a substantial threat to water bodies, making the exploration of effective treatment technologies imperative. Among these, biological denitrification stands out as one most efficient methods. Various materials, including biochar, graphene, carbon nanotubes, and nanoparticles, have gained widespread use across different industries due their unique properties. Numerous studies investigated impact these materials on microbial individually, focusing influence key enzymatic processes, functional genes, electron transport, proteins, metabolic activities. This manuscript aims contribute comprehensive holistic perspective by presenting consolidated data collective nanoparticles denitrification. The combination biochar microorganisms improves performance 415%. Graphene increases enzyme activity (100–175.4%). coupling nanotubes reduced 57.42%. Nanoparticles reduce (73.4%), (63%), transfer rate (52.4%) entering cell membrane. Moreover, been observed induce alterations in community structure involved delves into intricate details how conformational changes denitrifying enzymes, emphasizing relationship between structural modifications. Overall, this not only provides thorough analysis effects but also explores implications for dynamics enzymes. Furthermore, it outlines avenues future research, offering roadmap guide upcoming critical field.

Language: Английский

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