A comprehensive review on arsenic exposure and risk assessment in infants and young children diets: Health implications and mitigation interventions in a global perspective DOI Open Access

Lin Shu,

Guiling Yang, Shufang Liu

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 28, 2024

Abstract The early stages of human development are critical for growth, and exposure to arsenic, particularly through the placenta dietary sources, poses significant health risks. Despite extensive research, gaps remain in our comprehension regional disparities arsenic its cumulative impacts during these developmental stages. We hypothesize that infants certain regions at greater risk associated complications. This review aims fill by providing a comprehensive synthesis epidemiological evidence related life, with an emphasis on underlying mechanisms toxicity contribute adverse outcomes, including neurodevelopmental impairments, immune dysfunction, cardiovascular diseases, cancer. Further, systematically comparing across Asia, Americas, Europe, findings reveal Bangladesh, Pakistan, India, exposed levels significantly exceeding reference value range 0.3–8 µg/kg/day, vulnerable inorganic arsenic. comparative analysis not only highlights geographic but also underscores variability regulatory frameworks. Finally, identifies life as window offers evidence‐based recommendations mitigating contamination infant foods. These strategies include improved agricultural practices, modifications, stricter limits products, encouragement low‐arsenic alternatives. Our work establishes framework future research policy aimed reducing burden from source table effectively addressing this public challenge.

Language: Английский

Chemical and Climatic Environmental Exposures and Epigenetic Aging: a Systematic Review DOI Creative Commons
Raj P. Fadadu, Anne K. Bozack, Andrés Cárdenas

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121347 - 121347

Published: March 1, 2025

Language: Английский

Citations

1
Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism DOI Creative Commons
John Dou, Rebecca J. Schmidt, Heather E. Volk

et al.

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 5, 2024

Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk attributed to genetic prenatal environmental factors, though the agents are incompletely characterized.

Language: Английский

Citations

4
Newborn metabolomic signatures of maternal vanadium exposure and reduced birth size DOI

Ya Jie Xie,

Gaga Mahai, Dan Zheng

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137625 - 137625

Published: Feb. 16, 2025

Language: Английский

Citations

0
Maternal smoking during pregnancy and blood lead levels in US children aged 1–15 years: associations modified by age and race DOI

Ian Alexander Sellars,

Jian Zhang,

G. Rogers

et al.

Paediatrics & Child Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Objectives Tobacco smoke is an important source of lead exposure. Maternal smoking during pregnancy likely transfers from the mother to child, contributing increased exposure in developing children. The present study aims examine association between maternal and blood levels (BLL) Methods A total 18,946 US children aged 1–15 years 1999–2016 National Health Nutrition Examination Survey were included. We defined with elevated BLL if ≥ 3.5 µg/dL. estimated odds ratios (ORs) born mothers who smoked versus nonsmoking mothers. Results decreasing trend prevalence occurred 1999 2016. After adjustment for other covariates, whose had significantly having (OR = 1.60; 95% confidence interval [CI] 1.25–2.06) compared stratified analyses revealed a significant existed 1–5 1.88 [95% CI 1.32–2.68]) 6–10 1.79 [1.07–2.98]), but not youths (11–15 years, OR 0.72 [0.37–1.40]). Being was found be associated high White (1.93 [1.35–2.77]) Black (2.03 [1.43–2.87]), low Hispanic (0.46 [0.23–0.92]). Conclusions demonstrates age- race-specific associations among contributes early life. Culturally appropriate interventions are needed further reduce pediatric population.

Language: Английский

Citations

0
Placental transfer and hazards of silver nanoparticles exposure during pregnancy: a review DOI
Yapeng Han, Chengxi Li, Yán Wāng

et al.

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(3), P. 1365 - 1389

Published: March 7, 2024

Language: Английский

Citations

3
The role of epigenetics in women’s reproductive health: the impact of environmental factors DOI Creative Commons

Xinru Yu,

Jiawei Xu,

Bihan Song

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

This paper explores the significant role of epigenetics in women's reproductive health, focusing on impact environmental factors. It highlights crucial link between epigenetic modifications-such as DNA methylation and histones post-translational modifications-and health issues, including infertility pregnancy complications. The reviews influence pollutants like PM2.5, heavy metals, endocrine disruptors gene expression through mechanisms, emphasizing need for understanding how dietary, lifestyle choices, exposure to chemicals affect health. Future research directions include deeper investigation into female leveraging editing mitigate changes improving IVF success rates managing disorders.

Language: Английский

Citations

3
Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence DOI
Lauren A. Eaves, Evans K. Lodge,

Wendy R Rohin

et al.

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

Citations

0
Fetal Growth Is Associated with Amniotic Fluid Antioxidant Capacity, Oxidative Stress, Minerals and Prenatal Supplementation: A Retrospective Study DOI Creative Commons
Mozhgan Kohzadi, Stan Kubow, Kristine G. Koski

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 184 - 184

Published: Feb. 5, 2025

Background: Associations of antioxidants in prenatal over-the-counter multivitamin-mineral (OTC MVM) supplements with in-utero oxidative stress (OS), antioxidant capacity, and fetal growth are limited. Our objectives were to determine if five ultrasound measurements [biparietal diameter (BPD), head circumference (HC), abdominal (AC), femur length (FL), estimated weight] associated OTC MVM minerals, biomarkers OS, total capacity amniotic fluid (AF). Methods: For this retrospective study, 176 pregnant women who had undergone age-related amniocentesis for genetic testing included. Questionnaires recorded supplementation (yes, no). Ultrasound early (16–20 weeks) late (32–36 gestation extracted from medical charts. AF concentrations 15 minerals trace elements OS [nitric oxide (NO), thiobarbituric acid-reactive substances (TBARS), ferric-reducing power (FRAP)] measured at 12–20 weeks gestation. biomarkers, measures analyzed using multiple linear regressions. Results: Positive associations observed between TBARS seven minerals/elements (calcium, copper, magnesium, nickel, strontium, zinc iron). At 16–20 weeks, selenium positively BPD, HC, AC, FL, respectively, NO was FRAP inversely weight. 32–36 calcium BPD chromium arsenic negatively HC. higher FL exposure continued be weight weeks. Conclusions: Concentrations linked specific different stages gestation, suggesting a complex interplay among utero supplements, growth.

Language: Английский

Citations

0
Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases DOI Open Access
Jürgen Gailer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3393 - 3393

Published: March 16, 2024

The ongoing anthropogenic pollution of the biosphere with As, Cd, Hg and Pb will inevitably result in an increased influx their corresponding toxic metal(loid) species into bloodstream human populations, including children pregnant women. To delineate whether measurable concentrations these inorganic pollutants are tolerable or implicated onset environmental diseases urgently requires new insight dynamic bioinorganic chemistry bloodstream–organ system. Owing to exposure multiple species, mechanism chronic toxicity each needs be integrated a framework better define underlying exposure–disease relationship. Accordingly, this review highlights some recent advances Cd2+, Hg2+ CH3Hg+ blood plasma, red cells target organs provides first glimpse emerging mechanisms toxicity. Although many important knowledge gaps remain, it is essential design experiments intent refining eventually establish that may allow us causally link cumulative populations unknown etiology do not appear have genetic origin. Thus, researchers from variety scientific disciplines need contribute interdisciplinary effort rationally address public health threat which require implementation stronger regulatory requirements improve planetary health, fundamentally intertwined.

Language: Английский

Citations

3
Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth DOI Creative Commons
Ting Wu,

Chuan Luo,

Tao Li

et al.

Maternal and Child Nutrition, Journal Year: 2024, Volume and Issue: 20(4)

Published: June 24, 2024

Abstract Exposure to certain heavy metals has been demonstrated be associated with a higher risk of preterm birth (PTB). However, studies focused on the effects other metal mixtures were limited. A nested case‒control study enrolling 94 PTB cases and 282 controls was conducted. Metallic elements detected in maternal plasma collected first trimester using inductively coupled plasma‒mass spectrometry. The effect exposure investigated logistic regression, least absolute shrinkage selection operator, restricted cubic spline (RCS), quantile g computation (QGC) Bayesian kernel machine regression (BKMR). Vanadium (V) arsenic (As) positively model, V remains multi‐exposure model. QGC analysis determined (69.42%) nickel (Ni) (70.30%) as maximum positive negative contributors risk, respectively. BKMR models further relationship between levels identified most important independent variable among elements. RCS showed an inverted U‐shape gestational age, more than 2.18 μg/L considered factor for shortened gestation length. metallic consisting V, As, cobalt, Ni, chromium manganese increased PTB, promoting incidence PTB.

Language: Английский

Citations

3