Copper Induced Astrocyte Cytosolic Escape of Mitochondrial DNA and Activation of Cgas-Sting-Nlrp3 Pathway-Dependent Pyroptosis DOI
Wei Shi, Qian Zhou, Lu Lu

et al.

Published: Jan. 1, 2024

Language: Английский

Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells DOI Creative Commons
Wei Shi, Qian Zhou, Lu Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117085 - 117085

Published: Sept. 24, 2024

Language: Английский

Citations

2
Parkin‐TLR4‐NLRP3 Axis Directs Melatonin to Alleviate Atrazine‐Induced Immune Impairment in Splenic Macrophages DOI
Shuo Liu,

Tian‐Ning Yang,

Yuxiang Wang

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(8)

Published: Nov. 1, 2024

ABSTRACT Atrazine (ATR) is a widespread environmental herbicide that seriously affects agricultural work and human safety. Melatonin (MLT) as an endogenous neuroendocrine hormone widely found in animals plants, which have antioxidant anti‐inflammatory effects. Pink1/Parkin‐mediated mitophagy keeps normal physiological processes by degrading damaged mitochondria cells. Therefore, we investigated the potential role mechanism of MLT ATR‐induced toxic injury spleen. The results showed alleviated unclear boundary between white pulp red It also shown ATR resulted swollen mitochondria, partial extinction mitochondrial membranes cristae, increased under action MLT. reactive oxygen species (ROS) activates Pink1/Parkin pathway, guides development then causes activation TLR4/NF‐κB inflammatory pathway. Meanwhile, these damages further exacerbated production NLRP3 inflammasomes, leading to spleen necrosis. Interestingly, changes were improved after treatment. Collectively, alleviates immune impairment splenic macrophages via regulating Parkin‐TLR4‐NLRP3 axis elucidates effect melatonin on provides novel perspective

Language: Английский

Citations

1
A New Insight into the Mechanism of Atrazine-Induced Neurotoxicity: Triggering Neural Stem Cell Senescence by Activating Integrated Stress Response Pathway DOI Creative Commons
Jian Chen, Xueyan Dai, Kanwar Kumar Malhi

et al.

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Atrazine (AT), a widely utilized chemical herbicide, causes widespread contamination of agricultural water bodies. Recently, exposure to AT has been linked the development age-related neurodegenerative diseases (NDs), suggesting its neurotoxicity potential. As an endocrine disruptor, targets hypothalamus, crucial part neuroendocrine system. However, toxicological mechanism hypothalamus and correlation with ND remain unexplored. Our results indicated that caused significant morphological structural damage leading loss mature intact neurons microglial activation. Furthermore, hypothalamic neural stem cells (HtNSCs) were recruited areas neuronal by AT. Through in vivo vitro experiments, we clarified outcomes AT-induced HtNSC recruitment alongside mature/intact neurons. Mechanistically, induces senescence these HtNSCs activating integrated stress response signaling. This consequently hinders repair damaged inhibiting proliferation differentiation. Overall, our findings underscore pivotal role pathway damage. Additionally, present study offers novel perspectives understand mechanisms provides preliminary evidence linking NDs.

Language: Английский

Citations

1
Copper Induced Astrocyte Cytosolic Escape of Mitochondrial DNA and Activation of Cgas-Sting-Nlrp3 Pathway-Dependent Pyroptosis DOI
Wei Shi, Qian Zhou, Lu Lu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0