Metabolomics reveals that phosphatidylethanolamine can alleviate the toxicity of silica nanoparticles in human lung A549 cells DOI
Shuang Chen, Chengze Liu,

Yifan Yang

et al.

Toxicology and Industrial Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Silica nanoparticles (SiNPs) are widely utilized in occupational settings where they can cause lung damage through inhalation. The objective of this research was to explore the metabolic markers SiNPs-induced toxicity on A549 cells by metabolomics and provide a foundation for studying nanoparticle-induced toxicity. Metabolomics analysis employed analyze metabolites SiNPs-treated cells. LASSO regression applied selection, protective measure experiments were conducted validate efficacy selected potential mitigators. After SiNPs treatment, 23 differential identified, including lipids, nucleotides, organic oxidants. Pathway revealed involvement various biological processes. further identified six significantly associated with Notably, phosphatidylethanolamine (PE (14:1(9Z)/14:0)) showed enrichment significant pathways an AUC 1 ROC curve. Protective verified its effect demonstrated considerable inhibition cytotoxicity. This study elucidated cytotoxicity PE as mitigator. These findings contribute understanding mechanisms inform health preventive strategies.

Language: Английский

Unseen threats in aquatic and terrestrial ecosystems: Nanoparticle persistence, transport and toxicity in natural environments DOI Creative Commons
Lebea N. Nthunya, Alseno K. Mosai, Eduardo Alberto López-Maldonado

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 382, P. 144470 - 144470

Published: May 15, 2025

Language: Английский

Citations

0
The Genetic and Epigenetic Toxicity of Silica Nanoparticles: An Updated Review DOI Creative Commons

Manjia Zheng,

Ziwei Chen,

Jiling Xie

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13901 - 13923

Published: Dec. 1, 2024

Silica nanoparticles (SiNPs) are widely used in biomedical fields, such as drug delivery, disease diagnosis, and molecular imaging. An increasing number of consumer products containing SiNPs being without supervision, the toxicity to human body is becoming a major problem. contact various ways cause damage structure function genetic material, potentially leading carcinogenesis, teratogenicity infertility. This review summarizes SiNPs-induced epigenetic toxicity, especially germ cells, explore their potential mechanisms. material mainly by inducing oxidative stress. Furtherly, mechanisms discussed detail for first time. alter DNA methylation, miRNA expression, histone modification inhibit chromatin remodeling regulating epigenetic-related enzymes transcription factors. beneficial investigating solutions avoid provide guidance better application field.

Language: Английский

Citations

1
Quantification of silica nanoparticle uptake at environmentally relevant concentrations by gold-core embedding DOI
Mei Wang, Jiaming Li, Biao Huang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176433 - 176433

Published: Sept. 25, 2024

Language: Английский

Citations

0
Metabolomics reveals that phosphatidylethanolamine can alleviate the toxicity of silica nanoparticles in human lung A549 cells DOI
Shuang Chen, Chengze Liu,

Yifan Yang

et al.

Toxicology and Industrial Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Silica nanoparticles (SiNPs) are widely utilized in occupational settings where they can cause lung damage through inhalation. The objective of this research was to explore the metabolic markers SiNPs-induced toxicity on A549 cells by metabolomics and provide a foundation for studying nanoparticle-induced toxicity. Metabolomics analysis employed analyze metabolites SiNPs-treated cells. LASSO regression applied selection, protective measure experiments were conducted validate efficacy selected potential mitigators. After SiNPs treatment, 23 differential identified, including lipids, nucleotides, organic oxidants. Pathway revealed involvement various biological processes. further identified six significantly associated with Notably, phosphatidylethanolamine (PE (14:1(9Z)/14:0)) showed enrichment significant pathways an AUC 1 ROC curve. Protective verified its effect demonstrated considerable inhibition cytotoxicity. This study elucidated cytotoxicity PE as mitigator. These findings contribute understanding mechanisms inform health preventive strategies.

Language: Английский

Citations

0