Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio) DOI Creative Commons
Jiaqi Xie,

Yuxiang Yin,

Bixiao Lin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116937 - 116937

Published: Sept. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Language: Английский

Effects of the plastic additive 2,4-di-tert-butylphenol on intestinal microbiota of zebrafish DOI
Yongmeng Yang,

Chen Yan,

Aifeng Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133987 - 133987

Published: March 8, 2024

Language: Английский

Citations

7
Screening and safety assessment of migrating substances released from biodegradable packaging materials into milk DOI
Chuang-Chuang Zhao, Qin‐Bao Lin,

Canghao Xie

et al.

Food Control, Journal Year: 2024, Volume and Issue: 166, P. 110755 - 110755

Published: July 20, 2024

Language: Английский

Citations

4
Effects of rosemary extract and its residue on production, immune performance, and gut microbiota in geese DOI Creative Commons

Yuzhi Huang,

Lanmeng Xu,

Hang He

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

To explore the effects of rosemary extract (RE) and its residue (RR) on production, immune performance, gut microbiota geese. We treat 28-day-old Sichuan white geese (n = 180) with three diets: (1) basal diet (control), (2) supplemented 0.02% RE, (3) 15% RR for 42 days. On day 70, compared control treatment, final body weight, average daily gain lysozyme levels in RE treatment increased significantly (p < 0.05). In treatments, there was a significant decrease alkaline phosphatase, globulin, high-density lipoprotein to also increase aspartate aminotransferase/alanine aminotransferase Moreover, both semi-eviscerated, eviscerated weights, calcium apparent digestibility significantly, along duodenal index Compared those had higher jejunum relative lengths, aminotransferase, uric acid, total cholesterol, low-density levels, decreased chest depth, angle, neck length, semi-eviscerated crude protein digestibility, triglyceride, There were no differences α or β diversities among treatments > abundance Turicibacter Sporobacter, Alistipes, Barnesiella Rikenellaceae, Succinivibrionaceae, Aeromonadales enriched Lachnospiraceae, Turicibacteraceae, Fusobacteriaceae, Enterobacteriaceae treatment. While we demonstrate be less effective than diet, it did improve production certain extent.

Language: Английский

Citations

0
Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity DOI
Zeyuan Li,

Ruicheng Qi,

Qiaoqiao Wang

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120839 - 120839

Published: Jan. 12, 2025

Language: Английский

Citations

0
Laccase immobilized on reduced graphene oxide sponges for simultaneous adsorption and enzymatic degradation of endocrine disrupting chemicals DOI Creative Commons

Mahsa Moayedi,

Nariman Yousefi

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139984 - 139984

Published: Jan. 1, 2025

Language: Английский

Citations

0
Long-term exposure to 2,4-di-tert-butylphenol impairs zebrafish fecundity and affects offspring development DOI

Huina Gao,

Yuchen Wang, Xuefang Liang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138108 - 138108

Published: March 1, 2025

Language: Английский

Citations

0
Ovarian toxicity of 2,6-di-tert-butyl-hydroxytoluene on female Ruditapes philippinarum: reproductive endocrine disruption and oxidative stress DOI
Xin Zheng, Xiaohui Li,

Ruicheng Qi

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138289 - 138289

Published: April 1, 2025

Language: Английский

Citations

0
Adverse effects of Microcystis aeruginosa exudates on the filtration, digestion, and reproduction organs of benthic bivalve Corbicula fluminea DOI Creative Commons

Zijin Hong,

Xun Chen,

Junxiang Hu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 13, 2024

Abstract Cyanobacteria bloom and the secondary metabolites released by microorganism are extremely harmful to aquatic animals, yet study on their adverse effects in zoobenthos is rare. Corbicula fluminea widely distributed freshwater environment with algal blooms. It a typical filter feeding that may be affected of cyanobacteria due its high filtering rate. In this study, C. was exposed Microcystis aeruginosa exudates (MaE) for 96 h, which obtained from 5 × 10 cells/mL 2.5 6 exponential stage M. culture solution represented cell density needs environmental risk precaution control emergent control, respectively. The responses critical organs MaE were analyzed evaluated based histopathological sections, antitoxicity biomarkers, organ function biomarkers. results showed all underwent structural disorders, vacuolization, apoptosis, necrosis, damage levels increased as concentration increased. detoxification antioxidant defense systems biomarkers each response exposure differently level reaction improved when siphon rate acetylcholinesterase activity filtration decreased significantly Increased glutathione S-transferase amylase digestive gland indicate it major . vitellogenin enlarged oocytes gonad have an estrogenic effect This demonstrates threat benthic bivalves inducing oxidative stress, inhibiting system, disturbing digestion system reproduction potential

Language: Английский

Citations

3
Polystyrene nanoplastics alter intestinal toxicity of 2,4-DTBP in a sex-dependent manner in zebrafish (Danio rerio) DOI
Ruimin Liu,

Huina Gao,

Xuefang Liang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135585 - 135585

Published: Aug. 22, 2024

Language: Английский

Citations

2
Autophagy and PPARs/NF-κB-associated inflammation are involved in hepatotoxicity induced by the synthetic phenolic antioxidant 2,4-di-tert-butylphenol in common carp (Cyprinus carpio) DOI Creative Commons
Jiaqi Xie,

Yuxiang Yin,

Bixiao Lin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116937 - 116937

Published: Sept. 2, 2024

The synthetic phenolic antioxidant 2,4-di-tert-butylphenol (2,4-DTBP) is an emergent contaminant and can disrupt the delicate balance of aquatic ecosystems. This study aimed to investigate 2,4-DTBP-induced hepatotoxicity in common carp underlying mechanisms involved. Sixty were divided into four groups exposed 0 mg/L, 0.01 0.1 mg/L or 1 2,4-DTBP for 30 days. Here, we first demonstrated that exposure caused liver damage, manifested as hepatocyte nuclear pyknosis, inflammatory cell infiltration apoptosis. Moreover, induced hepatic reactive oxygen species (ROS) overload disrupted capacity, indicated by reduced activity enzymes superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GSH-Px). In addition, transmission electron microscopy revealed autophagosome accumulation carp. Western blot analysis further significantly decreased protein levels mTOR increased LC3II/LC3I ratio. Furthermore, inhibited lysozyme (LZM) alkaline phosphatase (AKP) activity; immunoglobulin M (IgM), complement 3 (C3), 4 (C4) serum; mRNA proinflammatory cytokines (NF-κB, TNF-α, IL-1β IL-6); three types proliferator-activated receptors (PPARs) (α, β/δ γ). Molecular docking directly binds internal active pocket PPARs. Overall, concluded systems could induce regulating autophagy controlling responses. present provides new insights mechanism organisms furthers our understanding effects on public health ecotoxicology.

Language: Английский

Citations

0