Gut Microbiota-Derived Leucine Promotes Cold-Induced Atherosclerosis by Inhibiting Macrophage Efferocytosis DOI Creative Commons

Yongtai Gong,

Sen Yan, Ning Fang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Abstract Cold exposure has been shown to impact the development of atherosclerotic cardiovascular disease (ASCVD) and is associated with dysbiosis in gut microbiota. In our study, we found that cold increased both plaque area instability ApoE−/− mice. Further analysis revealed microbiota microbial metabolites play a crucial role cold-related atherosclerosis. Specifically, following exposure, there was notable decrease abundance Lactobacillus. johnsonii (L. johnsonii) intestinal tract an increase plasma leucine levels. Supplementation L. alleviated atherosclerosis Importantly, vivo vitro studies demonstrated reduces efferocytosis by decreasing expression Gas6 macrophages, thereby promoting progression These findings highlight central modulating during The johnsonii-leucine-Gas6 pathway holds promise as potential therapeutic target for addressing

Language: Английский

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease DOI Creative Commons
Pierluigi Rio, Mario Caldarelli, Antonio Gasbarrini

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(6), P. 118 - 118

Published: June 3, 2024

According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution

Language: Английский

Citations

5
Exploring the role of nutritional strategies to influence physiological and cognitive mechanisms in cold weather operations in military personnel DOI Creative Commons

Dagmar J. Smid,

Lisa Klous,

Sam B. Ballak

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Introduction As a basis for performance optimal nutritional balance is key to keep the body functioning at homeostatic capacity. When environmental circumstances become challenging such as in cold environment extraordinary requested specifically physiological (i.e., vascular response, diet induced thermogenesis, immune response), and cognitive mechanisms function, psychological wellbeing) of human body. In this review we describe which strategies could enhance military by mitigation CWIs. Methods We will first how exposure affects or itself then explain nutrition can be used optimize these affected mechanisms. discuss long-term solutions preventing shortfalls potential direct quick fixes Results For system infection prevention, absence micronutrient deficiencies should pursued amongst personnel. effectivity PUFA’s, Echinacea purpurea probiotics functioning, more research needed CWO context. A multitude micronutrients nitrate, L-citrulline, L-arginine) appears able vasodilation, perhaps partially offsetting detrimental effect on peripheral blood circulation. Although thermogenesis small comparison being physically active, it interest investigate effects adding combination spices rations, capsaicin from red pepper, cinnamon, ginger, menthol. Also, stimulation are caffeine, polyphenolic compounds. Caffeine tyrosine supplementation 1 h, resp. 2 h before cognitively demanding task during CWOs mitigate decreases performance. Alternatives that interest, but need research, include chocolate polyphenols omega-3 fatty acids. Conclusion Even though some recommendations provided, evident much information regarding effectiveness application weather operations still lacking. More focus placed investigating (micro)nutritional solutions, practical feasibility, implementation operational personnel better understand magnitude possible benefits conditions.

Language: Английский

Citations

0
Gut microbiota metabolites: potential therapeutic targets for Alzheimer’s disease? DOI Creative Commons
Shanshan Zhang, Jing Lu, Ziqi Jin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 17, 2024

Background Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive decline in cognitive function, which significantly increases pain and social burden. However, few therapeutic interventions are effective preventing or mitigating the progression of AD. An increasing number recent studies support hypothesis that gut microbiome its metabolites may be associated with upstream regulators AD pathology. Methods In this review, we comprehensively explore potential mechanisms currently available targeting for improvement Our discussion structured around modern research advancements AD, bidirectional communication between brain, multi-target regulatory effects microbial on strategies aimed at modulating microbiota to manage Results The plays crucial role pathogenesis through continuous via microbiota-gut-brain axis. Among these, such as lipids, amino acids, bile acids neurotransmitters, especially sphingolipids phospholipids, serve central components gut-brain axis, regulating AD-related pathogenic including β-amyloid metabolism, Tau protein phosphorylation, neuroinflammation. Additionally, probiotic administration, fecal transplantation, antibiotic use have also provided evidence supporting association At same time, propose an innovative strategy treating AD: healthy lifestyle combined targeted probiotics other interventions, aiming restore intestinal ecology balance. Conclusion Despite previous efforts, molecular microbes act yet fully described. microorganisms become essential target connecting axis improving symptoms it requires joint exploration multiple centers disciplines.

Language: Английский

Citations

2
Comparative transcriptomic analysis reveals the gut-brain axis regulatory mechanisms in cold-tolerant pufferfish (Takifugu fasciatus) under cold stress DOI

Jie Wang,

Shuang Han, Yuhao Luo

et al.

Aquaculture, Journal Year: 2024, Volume and Issue: unknown, P. 742033 - 742033

Published: Dec. 1, 2024

Language: Английский

Citations

2
Mechanism of cold exposure delaying wound healing in mice DOI Creative Commons

Fu‐Xing‐Zi Li,

Jun-Jie Liu,

Li-Min Lei

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 20, 2024

Cold temperatures have been shown to slow skin wound healing. However, the specific mechanisms underlying cold-induced impairment of healing remain unclear. Here, we demonstrate that small extracellular vesicles derived from cold-exposed mouse plasma (CT-sEVs) decelerate re-epithelialization, increase scar width, and weaken angiogenesis. CT-sEVs are enriched with miRNAs involved in regulation healing-related biological processes. Functional assays revealed miR-423-3p, CT-sEVs, acts as a critical mediator angiogenic responses poor by inhibiting phosphatase poly(A) binding protein cytoplasmic 1 (PABPC1). These findings indicate cold delays via miR-423-3p plasma-derived sEVs through inhibition ERK or AKT phosphorylation pathways. Our results enhance understanding molecular which exposure soft tissue

Language: Английский

Citations

1
Gut Microbiota-Derived Leucine Promotes Cold-Induced Atherosclerosis by Inhibiting Macrophage Efferocytosis DOI Creative Commons

Yongtai Gong,

Sen Yan, Ning Fang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Abstract Cold exposure has been shown to impact the development of atherosclerotic cardiovascular disease (ASCVD) and is associated with dysbiosis in gut microbiota. In our study, we found that cold increased both plaque area instability ApoE−/− mice. Further analysis revealed microbiota microbial metabolites play a crucial role cold-related atherosclerosis. Specifically, following exposure, there was notable decrease abundance Lactobacillus. johnsonii (L. johnsonii) intestinal tract an increase plasma leucine levels. Supplementation L. alleviated atherosclerosis Importantly, vivo vitro studies demonstrated reduces efferocytosis by decreasing expression Gas6 macrophages, thereby promoting progression These findings highlight central modulating during The johnsonii-leucine-Gas6 pathway holds promise as potential therapeutic target for addressing

Language: Английский

Citations

0