A transcriptomics-based analysis of mechanisms involved in the neurobehavioral effects of 6PPD-quinone on early life stages of zebrafish DOI
Xuchun Qiu, Jie Tang,

Yibing Zhang

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 276, P. 107129 - 107129

Published: Oct. 19, 2024

Language: Английский

Exploring the neurodegenerative potential of per- and polyfluoroalkyl substances through an adverse outcome pathway network DOI Creative Commons
Sayed Esmaeil Mousavi, Qi Yu, Hyeong‐Moo Shin

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 969, P. 178972 - 178972

Published: Feb. 28, 2025

While emerging evidence links per- and polyfluoroalkyl substances (PFAS) to neurotoxicity, their potential role in neurodegeneration remains poorly understood. Moreover, existing neurodegeneration-related adverse outcome pathways (AOPs) available on AOP-Wiki have not yet been integrated into a unified network. To address these gaps, this study aims develop the first AOP network utilize it explore possible contributions of long-chain legacy PFAS neurodegeneration, specifically concerning Alzheimer's Parkinson's diseases. A total 74 AOPs were screened from AOP-Wiki, which 13 met eligibility criteria incorporated We analyzed resulting using topological parameters such as in-degree, out-degree, eccentricity, betweenness centrality. elucidate mechanistic exposure neurodegenerative pathways, we linking key events (KEs) within The results highlighted increased intracellular calcium hub with highest connectivity followed by critical KEs neuronal apoptosis, oxidative stress, N-methyl-d-aspartate receptor (NMDA-R) overactivation, mitochondrial dysfunction. Consistent toxicological evidence, indicate that may adversely affect neurotransmitter systems, particularly through NMDA-R leading excitotoxicity. This result dyshomeostasis, dysfunction, inflammatory-oxidative cascades, neuroinflammation, cell death. By providing basis for understanding PFAS, offers crucial framework assessing risks associated chemicals inform future regulatory measures public health strategies. Further experimental validation is needed confirm animal models or human populations.

Language: Английский

Citations

1
The hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae DOI
Ruirui Li, Wenping Xu,

Qiao‐Qiao Li

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120777 - 120777

Published: Jan. 6, 2025

Language: Английский

Citations

0
Sex specificity in associations between exposure to a mixture of per and poly-fluoroalkyl substances and anxiety among US adults DOI
Xiao‐Guo Hua, Renyu Hu, Cai Chen

et al.

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Perfluorooctanoic acid disrupts thyroid hormone biosynthesis by altering glycosylation of Na+/I− symporter in larval zebrafish DOI
Zhenzhen Cai, Guangdi Zhou, Xiaogang Yu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 297, P. 118249 - 118249

Published: April 29, 2025

Language: Английский

Citations

0
A transcriptomics-based analysis of mechanisms involved in the neurobehavioral effects of 6PPD-quinone on early life stages of zebrafish DOI
Xuchun Qiu, Jie Tang,

Yibing Zhang

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 276, P. 107129 - 107129

Published: Oct. 19, 2024

Language: Английский

Citations

1