Immunoregulation and male reproductive function: Impacts and mechanistic insights into inflammation
Yingjie Ma,
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Xinru Yu,
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Yi Liu
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et al.
Andrology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 21, 2024
Abstract
This
paper
investigates
the
complex
relationship
between
immune
system
and
male
reproductive
processes,
emphasizing
how
chronic
inflammation
can
adversely
affect
health.
The
plays
a
dual
role;
it
protects
regulates
organs
spermatogenesis
while
maintaining
health
through
privilege
in
testes
activities
of
various
cells
cytokines.
However,
when
persists
or
intensifies,
disrupt
this
balance,
leading
to
attacks
on
tissues
resulting
infertility.This
study
provides
detailed
analysis
impair
sperm
production,
quality,
secretion
gonadal
hormones
both
directly
indirectly.
It
also
delves
into
critical
roles
testicular
privilege,
cells,
cytokines
sustaining
examines
impacts
infections,
autoimmune
diseases,
environmental
factors
fertility.
Language: Английский
Bisphenol-S exposure of zebrafish unveils the hidden risks of bisphenol paradigm with growth, developmental, and behavioral impacts similar to bisphenol-A
Divani Shanika,
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Gayani Rajapaksa
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Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 20, 2025
The
introduction
of
bisphenol-S
(BPS)
in
substitution
bisphenol-A
(BPA)
has
become
argumentative
owing
to
their
endocrine
destructive
properties
and
insufficient
comparative
ecotoxicity
assessments.
Thus,
effects
long-term,
low-dose
BPA
BPS
exposure
on
the
development
juvenile
zebrafish
(Danio
rerio)
were
investigated.
Juvenile
(age:
21
days;
weight:
~
61.5
mg;
length:
7.56
mm)
exposed
environmentally-relevant
50
µg/L
BPA,
BPS,
control
for
60
days
triplicate.
Both
significantly
increased
length
(p
=
0.00),
weight
specific
growth
rate
female
preponderance
0.003),
mortality
0.017),
ammonia
excretion
aggression
0.00)
compared
control.
bisphenols
reduced
fish
swimming
speed
a
comparable
manner
0.001).
A
notably
higher
female-biased-sex
ratio
was
observed
than
0.003).
gain
0.014)
0.032)
BPA-treated
BPS.
However,
significant
difference
not
shown
body
mass
index
0.295)
condition
factor
0.256)
between
<
0.05).
led
hyperplasia,
mucous
secretion,
aneurism
gills,
vacuolization
necrosis
liver.
Therefore,
(~
µg/L)
also
imposes
noteworthy
threats
aquatic
wildlife,
emphasizing
necessity
toxicity
assessments
regular
monitoring
aiming
at
bespoken
environmental
standards
freshwater.
Language: Английский
Effectiveness of Lignocellulose Nanofibers (LNCFS) for removing nitrite, nitrate, and phosphate from Gamishan wastewater
Saeedeh Rastegar,
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Wahid Zamani,
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Monireh Faghani
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et al.
Aquaculture Reports,
Journal Year:
2025,
Volume and Issue:
42, P. 102777 - 102777
Published: March 29, 2025
Language: Английский
Microcystis aeruginosa decreased fish appetite via inducing intestinal inflammation
Zhihao Ju,
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Qianqian Xiang,
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Yihong Pan
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et al.
Fish & Shellfish Immunology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 110428 - 110428
Published: May 1, 2025
Language: Английский
Exploring a novel toxicological mechanism: Ammonia-N induces neurotoxicity, oxidative damage in brain tissue, and modulates the expression of central appetite factors to suppress feeding in juvenile Siberian sturgeon (Acipenser baerii Brandt)
Xin Zhang,
No information about this author
Q. Hu,
No information about this author
Huimin Sun
No information about this author
et al.
Aquaculture,
Journal Year:
2024,
Volume and Issue:
595, P. 741725 - 741725
Published: Oct. 6, 2024
Language: Английский
A Time-Dependent Interactive Effect of Nitrite and Ammonia on Inflammatory and Immune Response in the Head Kidney of Silver Carp (Hypophthalmichthys Molitrix)
Yiwen Li,
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Honghui Guo,
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Hen Ge
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et al.
Published: Jan. 1, 2024
Nitrite
and
ammonia
stress
frequently
have
harmful
effects
on
aquatic
animals.
However,
the
effect
of
combined
with
nitrite
immunity
is
unclear.
The
present
study
aimed
to
determine
interactive
silver
carp
head
kidney.
Fish
were
exposed
(15
mg/L),
(10
or
ammonia+nitrite
mg/L+10
control
conditions
for
24
48
h.
results
showed
that
exposure
caused
loss
cytoplasm
vacuolar
degeneration
cells
in
Following
ammonia,
tumor
necrosis
factor
alpha
(TNF-α)
interleukin-1β
(IL-1β)
levels
decreased
significantly
kidney,
while
content
immunoglobulin
M
(IgM),
complement
3
(C3),
4
(C4)
increased
(P
<
0.05).
Additionally,
TNF-α,
IL-1β,
IgM,
C3
affected
synergistically
by
hours
an
antagonistic
was
observed
after
hour
exposure.
After
exposure,
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
analyses
differently
expressed
genes
induced
nitrite,
their
combination
mainly
assigned
molecular
function
biological
process.
Ammonia
regulated
20
immunity-associated
pathways,
21
pathways.
Moreover,
coagulation
cascade
enriched
highest
number
differentially
under
combination.
integrated
biomarker
response
(IBR)
group
higher
than
group,
IBR
respectively.
In
conclusion,
toxicities
toward
kidney
displayed
inflammatory
suppression
immune
activation,
more
toxic
ammonia.
had
synergistic
at
h
h,
Language: Английский
Bloom-forming planktonic Microcystis and benthic Oscillatoria-induced oxidative stress and inflammatory responses in juvenile silver carp and bighead carp
Huiting Yang,
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Yu-jia Yao,
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Xiaohong Gu
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et al.
Toxicon,
Journal Year:
2024,
Volume and Issue:
253, P. 108183 - 108183
Published: Nov. 20, 2024
Language: Английский
Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway
Wang Lin,
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Fen Hu,
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Wansheng Zou
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et al.
Toxins,
Journal Year:
2024,
Volume and Issue:
16(12), P. 549 - 549
Published: Dec. 18, 2024
Microcystin-leucine
arginine
(MC-LR)
poses
a
serious
threat
to
aquatic
animals
during
cyanobacterial
blooms.
Recently,
biochar
(BC),
derived
from
rice
straw,
has
emerged
as
potent
adsorbent
for
eliminating
hazardous
contaminants
water.
To
assess
the
joint
hepatotoxic
effects
of
environmentally
relevant
concentrations
MC-LR
and
BC
on
fish,
male
adult
zebrafish
(Danio
rerio)
were
sub-chronically
co-exposed
varying
(0,
1,
5,
25
μg/L)
(0
100
in
fully
factorial
experiment.
After
30
days
exposure,
our
findings
suggested
that
existence
significantly
decreased
bioavailability
liver.
Furthermore,
histopathological
analysis
revealed
mitigated
MC-LR-induced
hepatic
lesions,
which
characterized
by
mild
damage,
such
vacuolization,
pyknotic
nuclei,
swollen
mitochondria.
Compared
groups
exposed
solely
MC-LR,
malondialdehyde
(MDA)
increased
catalase
(CAT)
superoxide
dismutase
(SOD)
noticed
mixture
groups.
Concurrently,
significant
changes
mRNA
expression
levels
Nrf2
pathway
genes
(cat,
sod1,
gstr,
keap1a,
nrf2a,
gclc)
further
proved
reduces
oxidative
damage
induced
MC-LR.
These
demonstrate
decreases
liver,
thereby
alleviating
hepatotoxicity
through
signaling
zebrafish.
Our
results
also
imply
could
serve
potentially
friendly
material
mitigating
detrimental
fish.
Language: Английский