Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway DOI Creative Commons
Wang Lin, Fen Hu,

Wansheng Zou

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 549 - 549

Published: Dec. 18, 2024

Microcystin-leucine arginine (MC-LR) poses a serious threat to aquatic animals during cyanobacterial blooms. Recently, biochar (BC), derived from rice straw, has emerged as potent adsorbent for eliminating hazardous contaminants water. To assess the joint hepatotoxic effects of environmentally relevant concentrations MC-LR and BC on fish, male adult zebrafish (Danio rerio) were sub-chronically co-exposed varying (0, 1, 5, 25 μg/L) (0 100 in fully factorial experiment. After 30 days exposure, our findings suggested that existence significantly decreased bioavailability liver. Furthermore, histopathological analysis revealed mitigated MC-LR-induced hepatic lesions, which characterized by mild damage, such vacuolization, pyknotic nuclei, swollen mitochondria. Compared groups exposed solely MC-LR, malondialdehyde (MDA) increased catalase (CAT) superoxide dismutase (SOD) noticed mixture groups. Concurrently, significant changes mRNA expression levels Nrf2 pathway genes (cat, sod1, gstr, keap1a, nrf2a, gclc) further proved reduces oxidative damage induced MC-LR. These demonstrate decreases liver, thereby alleviating hepatotoxicity through signaling zebrafish. Our results also imply could serve potentially friendly material mitigating detrimental fish.

Language: Английский

Immunoregulation and male reproductive function: Impacts and mechanistic insights into inflammation DOI Open Access
Yingjie Ma,

Xinru Yu,

Yi Liu

et al.

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract This paper investigates the complex relationship between immune system and male reproductive processes, emphasizing how chronic inflammation can adversely affect health. The plays a dual role; it protects regulates organs spermatogenesis while maintaining health through privilege in testes activities of various cells cytokines. However, when persists or intensifies, disrupt this balance, leading to attacks on tissues resulting infertility.This study provides detailed analysis impair sperm production, quality, secretion gonadal hormones both directly indirectly. It also delves into critical roles testicular privilege, cells, cytokines sustaining examines impacts infections, autoimmune diseases, environmental factors fertility.

Language: Английский

Citations

6
Bisphenol-S exposure of zebrafish unveils the hidden risks of bisphenol paradigm with growth, developmental, and behavioral impacts similar to bisphenol-A DOI Creative Commons

Divani Shanika,

Gayani Rajapaksa

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 20, 2025

The introduction of bisphenol-S (BPS) in substitution bisphenol-A (BPA) has become argumentative owing to their endocrine destructive properties and insufficient comparative ecotoxicity assessments. Thus, effects long-term, low-dose BPA BPS exposure on the development juvenile zebrafish (Danio rerio) were investigated. Juvenile (age: 21 days; weight: ~ 61.5 mg; length: 7.56 mm) exposed environmentally-relevant 50 µg/L BPA, BPS, control for 60 days triplicate. Both significantly increased length (p = 0.00), weight specific growth rate female preponderance 0.003), mortality 0.017), ammonia excretion aggression 0.00) compared control. bisphenols reduced fish swimming speed a comparable manner 0.001). A notably higher female-biased-sex ratio was observed than 0.003). gain 0.014) 0.032) BPA-treated BPS. However, significant difference not shown body mass index 0.295) condition factor 0.256) between < 0.05). led hyperplasia, mucous secretion, aneurism gills, vacuolization necrosis liver. Therefore, (~ µg/L) also imposes noteworthy threats aquatic wildlife, emphasizing necessity toxicity assessments regular monitoring aiming at bespoken environmental standards freshwater.

Language: Английский

Citations

0
Effectiveness of Lignocellulose Nanofibers (LNCFS) for removing nitrite, nitrate, and phosphate from Gamishan wastewater DOI
Saeedeh Rastegar,

Wahid Zamani,

Monireh Faghani

et al.

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 42, P. 102777 - 102777

Published: March 29, 2025

Language: Английский

Citations

0
Microcystis aeruginosa decreased fish appetite via inducing intestinal inflammation DOI Creative Commons

Zhihao Ju,

Qianqian Xiang, Yihong Pan

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110428 - 110428

Published: May 1, 2025

Language: Английский

Citations

0
Exploring a novel toxicological mechanism: Ammonia-N induces neurotoxicity, oxidative damage in brain tissue, and modulates the expression of central appetite factors to suppress feeding in juvenile Siberian sturgeon (Acipenser baerii Brandt) DOI
Xin Zhang, Q. Hu, Huimin Sun

et al.

Aquaculture, Journal Year: 2024, Volume and Issue: 595, P. 741725 - 741725

Published: Oct. 6, 2024

Language: Английский

Citations

1
A Time-Dependent Interactive Effect of Nitrite and Ammonia on Inflammatory and Immune Response in the Head Kidney of Silver Carp (Hypophthalmichthys Molitrix) DOI
Yiwen Li, Honghui Guo,

Hen Ge

et al.

Published: Jan. 1, 2024

Nitrite and ammonia stress frequently have harmful effects on aquatic animals. However, the effect of combined with nitrite immunity is unclear. The present study aimed to determine interactive silver carp head kidney. Fish were exposed (15 mg/L), (10 or ammonia+nitrite mg/L+10 control conditions for 24 48 h. results showed that exposure caused loss cytoplasm vacuolar degeneration cells in Following ammonia, tumor necrosis factor alpha (TNF-α) interleukin-1β (IL-1β) levels decreased significantly kidney, while content immunoglobulin M (IgM), complement 3 (C3), 4 (C4) increased (P < 0.05). Additionally, TNF-α, IL-1β, IgM, C3 affected synergistically by hours an antagonistic was observed after hour exposure. After exposure, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses differently expressed genes induced nitrite, their combination mainly assigned molecular function biological process. Ammonia regulated 20 immunity-associated pathways, 21 pathways. Moreover, coagulation cascade enriched highest number differentially under combination. integrated biomarker response (IBR) group higher than group, IBR respectively. In conclusion, toxicities toward kidney displayed inflammatory suppression immune activation, more toxic ammonia. had synergistic at h h,

Language: Английский

Citations

0
Bloom-forming planktonic Microcystis and benthic Oscillatoria-induced oxidative stress and inflammatory responses in juvenile silver carp and bighead carp DOI

Huiting Yang,

Yu-jia Yao,

Xiaohong Gu

et al.

Toxicon, Journal Year: 2024, Volume and Issue: 253, P. 108183 - 108183

Published: Nov. 20, 2024

Language: Английский

Citations

0
Rice Straw-Derived Biochar Mitigates Microcystin-LR-Induced Hepatic Histopathological Injury and Oxidative Damage in Male Zebrafish via the Nrf2 Signaling Pathway DOI Creative Commons
Wang Lin, Fen Hu,

Wansheng Zou

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(12), P. 549 - 549

Published: Dec. 18, 2024

Microcystin-leucine arginine (MC-LR) poses a serious threat to aquatic animals during cyanobacterial blooms. Recently, biochar (BC), derived from rice straw, has emerged as potent adsorbent for eliminating hazardous contaminants water. To assess the joint hepatotoxic effects of environmentally relevant concentrations MC-LR and BC on fish, male adult zebrafish (Danio rerio) were sub-chronically co-exposed varying (0, 1, 5, 25 μg/L) (0 100 in fully factorial experiment. After 30 days exposure, our findings suggested that existence significantly decreased bioavailability liver. Furthermore, histopathological analysis revealed mitigated MC-LR-induced hepatic lesions, which characterized by mild damage, such vacuolization, pyknotic nuclei, swollen mitochondria. Compared groups exposed solely MC-LR, malondialdehyde (MDA) increased catalase (CAT) superoxide dismutase (SOD) noticed mixture groups. Concurrently, significant changes mRNA expression levels Nrf2 pathway genes (cat, sod1, gstr, keap1a, nrf2a, gclc) further proved reduces oxidative damage induced MC-LR. These demonstrate decreases liver, thereby alleviating hepatotoxicity through signaling zebrafish. Our results also imply could serve potentially friendly material mitigating detrimental fish.

Language: Английский

Citations

0