ER-organelle contacts: A signaling hub for neurological diseases DOI Creative Commons
Yunli Wang, Jinghua Yang

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107149 - 107149

Published: March 20, 2024

Neuronal health is closely linked to the homeostasis of intracellular organelles, and organelle dysfunction affects pathological progression neurological diseases. In contrast isolated cellular compartments, a growing number studies have found that organelles are largely interdependent structures capable communicating through membrane contact sites (MCSs). MCSs been identified as key pathways mediating inter-organelle communication crosstalk in neurons, their alterations disease pathology. The endoplasmic reticulum (ER) membrane-bound forming an extensive network pools tubules with important physiological functions within neurons. There multiple between ER other plasma (PM), which regulate variety processes. this review, we focus on ER-organelle role We compared biological effects different tethering proteins respective counterparts. also discuss how altered contacts may affect pathogenesis. Therefore, understanding molecular mechanisms neuronal will lay foundation for development new therapies targeting contacts.

Language: Английский

Exploring the neurodegenerative potential of per- and polyfluoroalkyl substances through an adverse outcome pathway network DOI Creative Commons
Sayed Esmaeil Mousavi, Qi Yu, Hyeong‐Moo Shin

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 969, P. 178972 - 178972

Published: Feb. 28, 2025

While emerging evidence links per- and polyfluoroalkyl substances (PFAS) to neurotoxicity, their potential role in neurodegeneration remains poorly understood. Moreover, existing neurodegeneration-related adverse outcome pathways (AOPs) available on AOP-Wiki have not yet been integrated into a unified network. To address these gaps, this study aims develop the first AOP network utilize it explore possible contributions of long-chain legacy PFAS neurodegeneration, specifically concerning Alzheimer's Parkinson's diseases. A total 74 AOPs were screened from AOP-Wiki, which 13 met eligibility criteria incorporated We analyzed resulting using topological parameters such as in-degree, out-degree, eccentricity, betweenness centrality. elucidate mechanistic exposure neurodegenerative pathways, we linking key events (KEs) within The results highlighted increased intracellular calcium hub with highest connectivity followed by critical KEs neuronal apoptosis, oxidative stress, N-methyl-d-aspartate receptor (NMDA-R) overactivation, mitochondrial dysfunction. Consistent toxicological evidence, indicate that may adversely affect neurotransmitter systems, particularly through NMDA-R leading excitotoxicity. This result dyshomeostasis, dysfunction, inflammatory-oxidative cascades, neuroinflammation, cell death. By providing basis for understanding PFAS, offers crucial framework assessing risks associated chemicals inform future regulatory measures public health strategies. Further experimental validation is needed confirm animal models or human populations.

Language: Английский

Citations

0
The endoplasmic reticulum-mitochondrial crosstalk involved in nanoplastics and di(2-ethylhexyl) phthalate co-exposure induced the damage to mouse mammary epithelial cells DOI
Caihong Wang, Xiang Ji, Xiaoya Wang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126014 - 126014

Published: March 6, 2025

Language: Английский

Citations

0
Associations of Serum Per- and Polyfluoroalkyl Substances with Genotoxic Biomarkers: New Insights from Cross-Sectional and In Vivo Evidence DOI Creative Commons
Peiwei Xu, Dihui Xu, Xiaofeng Wang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

The effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) on genomic stability remain unclear. Here, a cross-sectional study was conducted to establish the associations PFAS with genotoxic biomarkers. We recruited cohort 453 residents in 2021 Zhejiang, China. Thirty serum were quantified, alongside seven indicators [five rDNA copy numbers (rDNA-CN), mitochondrial DNA (mtDNA-CN), relative telomere length (RTL)] whole blood. Results showed that PFUnDA, perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic (PFOS), 6:2 Cl-PFESA, PFO5DoDA positively correlated rDNA-CN, while PFHpA, PFOA, PFMOAA inverse associations. PFO4DA mtDNA-CN. HFPO-TA, negatively associated RTL, perfluorononanoic acid, PFHxS, PFOS, Cl-PFESA positive Nonlinear exposure-response relationships also observed between biomarkers using restricted cubic spline models. Furthermore, mixtures mtDNA-CN, showing highest contribution by quantile-based g-computation model. In vivo studies further confirmed increased mtDNA-CN male mice dose-dependent manner. This provides novel evidence disrupt stability, varying functional groups fluoroalkyl(ether) chain lengths.

Language: Английский

Citations

0
The Toxic Effects and Mechanisms of Maternal Exposure to Bisphenol F During Gestation and Lactation on Lungs in Female Offspring Mice DOI

Jiayu Du,

Siming Huo, Bo Li

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 361, P. 124800 - 124800

Published: Aug. 22, 2024

Language: Английский

Citations

1
ER-organelle contacts: A signaling hub for neurological diseases DOI Creative Commons
Yunli Wang, Jinghua Yang

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107149 - 107149

Published: March 20, 2024

Neuronal health is closely linked to the homeostasis of intracellular organelles, and organelle dysfunction affects pathological progression neurological diseases. In contrast isolated cellular compartments, a growing number studies have found that organelles are largely interdependent structures capable communicating through membrane contact sites (MCSs). MCSs been identified as key pathways mediating inter-organelle communication crosstalk in neurons, their alterations disease pathology. The endoplasmic reticulum (ER) membrane-bound forming an extensive network pools tubules with important physiological functions within neurons. There multiple between ER other plasma (PM), which regulate variety processes. this review, we focus on ER-organelle role We compared biological effects different tethering proteins respective counterparts. also discuss how altered contacts may affect pathogenesis. Therefore, understanding molecular mechanisms neuronal will lay foundation for development new therapies targeting contacts.

Language: Английский

Citations

0