Integrating environmental effects in the benefit-risk assessment of therapeutic products: a proposal and example for sustainable health and healthcare
Emiliano Giovagnoni,
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Luisa Mattoli,
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Andrea Cossu
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et al.
Frontiers in Drug Safety and Regulation,
Journal Year:
2025,
Volume and Issue:
4
Published: Jan. 17, 2025
To
mitigate
healthcare’s
unintended
effects,
environmental
risk
data
such
as
ecotoxicity
and
contamination
need
to
be
considered
by
all
stakeholders
in
the
healthcare
value
chain.
As
decision-makers
educators,
providers
are
a
unique
position
make
delivery
more
sustainable.
However,
current
benefit-risk
assessments
of
therapeutic
products
do
not
systematically
include
data.
The
purpose
this
paper
was
review
literature
regulatory
context
propose
expanding
an
evidence-based
evaluation
impact
inform
decision-making.
Our
findings
indicate
that
broadened
aspects
excipients,
synergistic
effects
contaminants,
risks
humans
(e.g.,
drinking
water).
Concrete
proposals
improve
guidelines
for
assessment
already
exist.
Open
access
databases
on
substances
used
human
consumption
available.
European
Union
Regulation
Medical
Devices
provides
basis
approach
developing
sustainable
based
natural
substances.
Based
this,
here
promoted
decision
scheme
(and
other
stakeholders)
involves
comparing
clinical
safety
efficacy
products;
data;
then
deciding.
A
case
example
involving
treatment
patients
with
gastroesophageal
reflux
dyspepsia
is
presented.
We
provide
suggestions
integrating
persistence
into
practice.
Expanding
during
decision-making
way
achieve
healthier
outcome
all.
Language: Английский
Recent occurrence of pharmaceuticals in freshwater, emerging treatment technologies, and future considerations: A review
Chemosphere,
Journal Year:
2025,
Volume and Issue:
374, P. 144153 - 144153
Published: Feb. 12, 2025
Language: Английский
Evolution of the Environmental Impact Assessment Process in Romania in the Context of Sustainable Development
Madalina Elena Abalasei,
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Daniela Fighir,
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Carmen Teodosiu
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et al.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(7), P. 3777 - 3777
Published: March 30, 2025
Environmental
Impact
Assessment
(EIA)
is
a
required
systematic
process
of
identifying,
predicting,
and
assessing
the
environmental
effects
proposed
actions
projects
such
as
nuclear
power
stations,
long-distance
railways,
motorways,
express
roads,
waste
disposal
installations
for
hazardous
waste,
dams
certain
capacity.
After
presenting
EIA
evolution
at
international
level,
its
introduction
into
Romanian
legislation
in
1973
discussed,
considering
criticism
regarding
main
problems
arising
from
widespread
implementation.
Although
some
studies
have
included
state-of-the-art
synthesis
effectiveness
concept,
there
are
no
reported
using
bibliometric
analysis
to
describe
detail
historical
development
process.
The
aim
this
study
analyze
Romania
context
sustainable
(SD).
To
achieve
objective,
data
obtained
implementation
PRISMA
methodology
were
considered.
For
purpose,
125
publications
on
selected,
review
Elsevier,
Scopus,
Springer
databases
period
2000–2024.
research
results
provide
practical
recommendations
decision-makers
practitioners
Romania,
aiming
strengthen
practices
with
purpose
ensuring
effective
principles.
Language: Английский
Enhanced catalytic degradation of acetaminophen using magnesium oxide-infused clay with ultrasonic activation of hydrogen peroxide
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(12), P. 106047 - 106047
Published: Nov. 6, 2024
Language: Английский
Combination of Biochar and Advanced Oxidation Processes for the Sustainable Elimination of Pharmaceuticals in Water
Sustainability,
Journal Year:
2024,
Volume and Issue:
16(23), P. 10761 - 10761
Published: Dec. 8, 2024
The
presence
of
pharmaceuticals
in
aquatic
ecosystems
is
an
issue
increasing
concern.
Regardless
the
low
concentration
water,
they
can
have
a
toxic
effect
on
both
humans
and
organisms.
Advanced
oxidation
processes
(AOPs)
been
described
as
promising
technique
for
eliminating
due
to
their
high
efficiency.
However,
cost
associated
with
application
these
reagents
energy
requirements
affected
implementation
AOPs
at
large
scales.
Biochar
has
suggested
be
used
catalyst
overcome
limitations.
considered
alternative
heterogeneous
thanks
its
physicochemical
characteristics
like
specific
surface
area,
porous
structure,
oxygen-containing
functional
groups,
electrical
conductivity,
persistent
free
radicals
(PFRs),
modifiable
properties,
structure
defects.
This
carbonaceous
material
presents
capacity
activate
oxidizing
agents
leading
formation
radical
species,
which
are
needed
degrade
pharmaceuticals.
Additionally,
AOP/biochar
systems
destroy
pharmaceutical
molecules
following
non-radical
pathway.
To
enhance
biochar
catalytic
performance,
modifications
such
iron
(Fe)
impregnation,
heteroatom
doping,
supporting
semiconductors
surface.
Although
efficiently
combination
several
mineralization
from
further
research
must
conducted
evaluate
different
regeneration
techniques
increase
biochar’s
sustainable
applicability
reduce
operational
combined
process.
Moreover,
conditions
influencing
system
required
evaluated
discern
find
that
maximize
degradation
by
systems.
Language: Английский