Accumulation of Per- and Polyfluoroalkyl Substances (PFAS) in Coastal Sharks from Contrasting Marine Environments: The New York Bight and The Bahamas DOI Creative Commons
Cheng‐Shiuan Lee, Oliver N. Shipley,

Xiayan Ye

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 13087 - 13098

Published: July 12, 2024

Per- and polyfluoroalkyl substances (PFAS) enter the marine food web, accumulate in organisms, potentially have adverse effects on predators consumers of seafood. However, evaluations PFAS meso-to-apex predators, like sharks, are scarce. This study investigated occurrence five shark species from two ecosystems with contrasting relative human population densities, New York Bight (NYB) coastal waters The Bahamas archipelago. total detected (∑PFAS) concentrations muscle tissue ranged 1.10 to 58.5 ng g

Language: Английский

Unveiling the emerging concern of per- and polyfluoroalkyl substances (PFAS) and their potential impacts on estuarine ecosystems DOI
Amit Hasan Anik,

Md. Samium Basir,

Maisha Binte Sultan

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 212, P. 117554 - 117554

Published: Jan. 20, 2025

Language: Английский

Citations

2
In Utero Perfluorodecanoic Acid Exposure Causes Fetal Leydig Cell Dysfunction via Endoplasmic Reticulum Stress-Mediated Lipid Composition Alteration DOI

Zheyuan Ren,

Chengshuang Pan,

Yaoyao Dong

et al.

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Perfluorodecanoic acid (PFDA), a C10 fluorine-containing compound, is used widely and found to be present anywhere. However, whether it has reproductive toxicity for fetal Leydig cells the underlying mechanisms remain unknown. PFDA was investigated its effects on (FLCs) following exposure 0, 1, 2.5, 5 mg/kg/days (gavage dams) from day 14 21 during gestation. The study showed that in utero medium-dose (1, 2.5 mg/kg/days) increased body weight. markedly reduced serum testosterone levels, downregulated FLC genes (Lhcgr, Star, Cyp11a1, Hsd3b1, Cyp17a1, Insl3), decreased their protein levels neonatal rat testes. at mg/kg/day altered lipid metabolism with upregulation of Elovl1 downregulation Scd2, subsequently inducing endoplasmic reticulum stress. Additionally, transcription factor Gli1, thereby inhibiting cell differentiation. Meanwhile, biosynthesis R2C vitro, stress inhibitor tauroursodeoxycholic (TUDCA) reversed this process. In conclusion, disrupts testicular metabolism, induces stress, interferes steroidogenesis network, leading dysfunction. This underscores potential environmental risk development male function development.

Language: Английский

Citations

0
Accumulation and trophic transfer of per- and polyfluoroalkyl substances (PFAS) in estuarine organisms determined via stable isotopes DOI

Kevin Shaffer,

Xiayan Ye,

Cheng‐Shiuan Lee

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 967, P. 178742 - 178742

Published: Feb. 12, 2025

Language: Английский

Citations

0
Accumulation of Per- and Polyfluoroalkyl Substances (PFAS) in Coastal Sharks from Contrasting Marine Environments: The New York Bight and The Bahamas DOI Creative Commons
Cheng‐Shiuan Lee, Oliver N. Shipley,

Xiayan Ye

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 13087 - 13098

Published: July 12, 2024

Per- and polyfluoroalkyl substances (PFAS) enter the marine food web, accumulate in organisms, potentially have adverse effects on predators consumers of seafood. However, evaluations PFAS meso-to-apex predators, like sharks, are scarce. This study investigated occurrence five shark species from two ecosystems with contrasting relative human population densities, New York Bight (NYB) coastal waters The Bahamas archipelago. total detected (∑PFAS) concentrations muscle tissue ranged 1.10 to 58.5 ng g

Language: Английский

Citations

2