Enantioselective Assessment of Etoxazole Enantiomers in Earthworms (Eisenia fetida): Bioaccumulation, Degradation, Transcriptome, and Oxidative Stress

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This study systemically investigated the enantioselective bioaccumulation and degradation of etoxazole (ETZ) in earthworms along with transcriptome oxidative stress responses to ETZ enantiomer exposure. Based on M-shaped trends for enantiomers,

Language: Английский

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Carbene-catalyzed Phthalide Ether Functionalization for Discovering Chiral Phytovirucides that Specifically Targets Viral Nia Protein to Inhibit Proliferation

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Plant diseases caused by vegetable viruses are an important threat to global food security, presenting a major challenge for the development of antiviral agrochemicals. Functional proteins plant play crucial role in viral life cycle, and targeted inhibition these has emerged as promising strategy. However, current discovery small molecules is hampered limitations synthetic approaches narrow range targets. Herein, we report practical application organocatalysis serving pesticide that bears unique molecular basis. An N -heterocyclic carbene-modulated reaction first designed asymmetrically functionalize diverse natural phenols with phthalides. Our method capable producing series new phthalidyl ethers under mild conditions good yields, enantioselectivity, functional group tolerance. Among these, compound ( R )- 3w exhibits excellent enantioselectivity-preferred curative activity against potato virus Y (PVY). Mechanistically, it proposed interacts nuclear inclusion body A (Nia) protein PVY at His150 residue. This binding impairs Nia’s function cleavage polyprotein, thereby inhibiting formation replication complex. The study provides insights into advancing protocol facilitate agrochemical discovery, our identified may serve potential lead future research PVY-Nia inhibitors.

Language: Английский

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Comparative study of fenpropathrin and its main metabolite in soil-earthworm microcosms: Toxicity, degradation, transcriptome, and oxidative stress

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 956, P. 177354 - 177354

Published: Nov. 7, 2024

Language: Английский

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Fundamentals of chirality: Enantioselective behavior and ecotoxicity of environmental chiral pollutants

Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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