Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 156 - 156

Published: Jan. 14, 2025

The intensification of aquaculture has escalated disease outbreaks and overuse antibiotics, driving the global antimicrobial resistance (AMR) crisis. Antimicrobial peptides (AMPs) provide a promising alternative due to their rapid, broad-spectrum activity, low AMR risk, additional bioactivities, including immunomodulatory, anticancer, antifouling properties. AMPs derived from aquatic invertebrates, particularly marine-derived, are well-suited for aquaculture, offering enhanced stability in high-salinity environments. This study compiles analyzes data AMP databases over 200 scientific sources, identifying approximately 350 mostly cationic α-helical, across 65 protein families. While vitro assays highlight potential, limited vivo studies hinder practical application. These could serve as feed additives, therapeutic agents, or genetic engineering approaches like CRISPR/Cas9-mediated transgenesis enhance resilience farmed species. Despite challenges such stability, ecological impacts, regulatory hurdles, advancements peptidomimetics hold significant promise. Future research should emphasize refining enhancement techniques, expanding diversity bioactivity profiles, prioritizing comprehensive evaluations. Harnessing potential represents step forward on path sustainability, reducing antibiotic dependency, combating AMR, ultimately safeguarding public health ecosystem resilience.

Language: Английский

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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods

Biotechnology for Biofuels and Bioproducts, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 16, 2025

Language: Английский

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Agroindustrial Plant Wastes: Novel Source of Antimicrobial Peptides

Circular Economy and Sustainability, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Current challenges and development strategies of bacteriocins produced by lactic acid bacteria applied in the food industry

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 14, 2024

Abstract Given the great importance of natural biopreservatives in modern food industry, lactic acid bacteria (LAB)‐producing bacteriocins have gained considerable attention due to their antimicrobial activity against foodborne pathogens and spoilage bacteria. Although numerous LAB‐producing demonstrated efficiency preserving quality various applications, only a limited number these compounds been commercially approved date. The currently unclear gastrointestinal metabolism may pose safety risks, as well cytotoxicity immunogenicity, which need be seriously considered before application. A more noteworthy concern lies whether induce an imbalance gut microbiota, thereby leading alterations abundance health‐associated microorganisms metabolites tract. Accordingly, this review presents unique insights into challenges arising from metabolic interactions between Besides, application industry faces low production yield, weak stability, insufficient activity. corresponding development strategies are proposed for conducting systematic comprehensive evaluation potential risks metabolites. also focus on rational design increase fermentation control enhance hurdle embedding technology improve effects. It definitively discloses perspective become natural, sustainable, safe, eco‐friendly biological preservatives advancement industry.

Language: Английский

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Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry

Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 100997 - 100997

Published: Jan. 1, 2025

Lactic acid bacteria (LAB) have been widely applied in the food industry and brought many beneficial effects on products, some of those benefits are related to their metabolic product. Bacteriocins produced by LAB attracted attentions for application as natural bio-preservatives because antimicrobial activity against spoilage pathogenic bacteria. With increasing demands consumers more healthier investigations preservatives, bioactivity bacteriocins allows them give values bacteriocin-producing LAB. Accordingly, capacity produce bacteriocin aspects classifications, mode action, biosynthesis mechanisms introduced, which leads further consideration current status potential industry. The comparation guidelines also proposed better understanding practical promising. This review will be helpful future researches

Language: Английский

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Computational analysis of antimicrobial peptides targeting key receptors in infection-related cardiovascular diseases: molecular docking and dynamics insights

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 14, 2025

Infection-related cardiovascular diseases (CVDs) pose a significant health challenge, driving the need for novel therapeutic strategies to target key receptors involved in inflammation and infection. Antimicrobial peptides (AMPs) show potential disrupt pathogenic processes offer promising approach CVD treatment. This study investigates binding of selected AMPs with critical implicated CVDs, aiming explore their potential. A comprehensive computational was employed assess AMP interactions CVD-related receptors, including ACE2, CRP, MMP9, NLRP3, TLR4. Molecular docking studies identified high affinities these targets, notably Tachystatin, Pleurocidin, Subtilisin A, which showed strong MMP9. Following docking, 100 ns molecular dynamics (MD) simulations confirmed stability AMP-receptor complexes, MM/PBSA calculations provided quantitative insights into energies, underscoring modulate receptor activity infection contexts. The highlights targeting infection-related pathways CVDs. These demonstrate properties models. Future research should focus on vitro vivo confirm efficacy safety, paving way clinical applications managing conditions.

Language: Английский

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Highly antibacterial and biocompatible polylysine-modified silk fibroin for potential food preservation and biomedical applications

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143130 - 143130

Published: April 1, 2025

Language: Английский

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Progress in the classification, optimization, activity, and application of antimicrobial peptides

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Antimicrobial peptides (AMPs) come from various sources and exhibit unique antimicrobial properties. Their rapid action, effectiveness, resistance to development make them promising alternatives combat antibiotic resistance. In addition its excellent antibacterial properties, AMPs have superior immunomodulatory, antitumor, antiviral activities. recent years, the demand for has continued increase in many fields, especially medical field, prospects are extensive. However, disadvantages of expensive cost, higher hemolysis, short half-life, susceptibility degradation by protein hydrolases, low bioavailability, toxic side effects, other disadvantages, which seriously limit wide application AMPs. Therefore, fewer been approved marketing or undergoing clinical trials. The review covers period 2001 2025 provides a detailed discussion searching databases such as Google Scholar Web Science. This paper reviews progress research on sources, structures, optimization strategies, biological activities, mechanisms applications. general, approaches number new increased significantly. improvement technologies high poor stability, bioavailability cost is still high, but widely used clinical, food, livestock, poultry, cosmetics fields. article focuses commonly strategies main activities AMPs, aiming effectively respond challenges provide theoretical basis expanding their range.

Language: Английский

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Antimicrobial peptide-chitosan nanoparticles combat ETEC-induced bacterial infection in mice

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144047 - 144047

Published: May 1, 2025

Language: Английский

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Effects of cecropin antimicrobial peptides on growth and intestinal health in growing male minks

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: May 14, 2025

This study investigated the effects of dietary supplementation with cecropin antimicrobial peptides (CAD) on growth performance and intestinal health in growing male minks (Neovison vison). A cohort 60 (65 days old) were evenly divided into six groups fed a basal diet supplemented CAD at 0 (control), 100, 200, 300, 400, or 500 mg/kg for 8 weeks. The findings revealed that 200 group had greater performance, significantly higher final body weight (FBW) average daily gain (ADG). Compared to control (p < 0.05). Digestibility analyses week 3 demonstrated enhanced ether extract (EE) digestibility 0.05), while improved crude protein (CP) Intestinal morphology assessments indicated increased duodenal jejunal villus height (both p 0.05) height-to-crypt depth ratio compared control. Serum immunological elevated levels complement C4 IgG CAD-supplemented Notably, 100 exhibited serum IgA, IgM, C3, less TNF-α (all Microbiota profiling showed reduced relative abundance Escherichia-Shigella Mycoplasma, 400 decreased Peptostreptococcaceae populations displayed optimal immune enhancement microbiota modulation, whereas achieved best function. These results suggest 100-200 effectively improves growth, nutrient utilization, minks.

Language: Английский

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