Suspect Screening of Pharmaceuticals and Their Transformation Products (TPs) in Wastewater during COVID-19 Infection Peak: Identification of New TPs and Elevated Risks

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Pharmaceuticals and their transformation products (TPs) in wastewater are emerging contaminants that pose risks to ecosystems human health. Here, a typical period marked by the easing of "zero-COVID" policy December 2022, resulting unprecedented infections China, was chosen illustrate environmental impact pharmaceutical usage during COVID-19 pandemic. A suspect screening workflow developed identify pharmaceuticals influent effluent from treatment plant (WWTP) peak postpeak periods COVID-19, integrating medication recommendations TPs' prediction. total 114 TPs were identified (13 detected for first time WWTP) using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). Wastewater-based epidemiology analysis showed most predominant nonsteroidal anti-inflammatory drugs. Interestingly, consumption propafenone increased after infection peak, possibly linked long symptoms. Risks further evaluated based on concentration, detection frequency, PMT (persistence, mobility, toxicity) properties, revealing aminopyrine, acetaminophen, etc. even greater ToxPi scores than parent compounds. This study highlights elevated posed discharge epidemics necessity monitoring.

Language: Английский

Predicting estrogen receptor agonists from plastic additives across various aquatic species using machine learning and AlphaFold2

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138629 - 138629

Published: May 14, 2025

Language: Английский

Antitussive drug dextromethorphan induces developmental impairment in zebrafish

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 486, P. 137042 - 137042

Published: Dec. 30, 2024

Language: Английский