Hepatotoxicity of Three Common Liquid Crystal Monomers in Mus musculus: Differentiation of Actions Across Different Receptors and Pathways
Zhichao Zhang,
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Shengjie Yuan,
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Zhongchao Yang
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et al.
Environmental Science & Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Liquid
crystal
monomers
(LCMs)
of
different
chemical
structures
were
widely
detected
in
various
environmental
matrices.
However,
their
health
risk
evaluation
is
lacking.
Herein,
three
representative
LCMs
selected
from
74
LCM
candidates
upon
literature
review
and
acute
cytotoxicity
evaluation,
then
Mus
musculus
exposed
to
the
for
42
days
at
doses
0.5
50
μg/kg/d
investigate
hepatotoxicity
mechanisms.
Phenotypic
histopathological
results
showed
that
(DTMDPB,
MeO3bcH,
5OCB)
induced
hepatomegaly,
only
5OCB
fatty
liver.
DTMDPB
MeO3bcH
decreased
total
cholesterol
(TCHO)
triglyceride
(TG)
content,
whereas
increased
TCHO,
TG,
alanine
aminotransferase
levels.
Transcriptome
molecular
docking
analysis
revealed
by
agonizing
farnesoid
X
receptor,
resulting
disruption
unsaturated
acid
biosynthesis,
ascorbic
antioxidant
pathways,
circadian
clock
homeostasis.
promoted
inflammation
altered
acid,
primary
bile
rhythm
antagonizing
aryl
hydrocarbon
receptor.
antagonized
peroxisome
proliferator-activated
receptors,
leading
liver
caused
steroid,
cholesterol,
terpenoid
backbone
biosynthesis
pathways.
This
study
provides
references
understanding
with
selection
priority
control
LCMs.
Language: Английский
Antimony release from e-waste-derived microplastics in aqueous environments: Effect of plastic properties and environmental factors
Liang Wu,
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Zijuan Zhong,
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Zhengdong Wang
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et al.
Environmental Pollution,
Journal Year:
2025,
Volume and Issue:
unknown, P. 125774 - 125774
Published: Jan. 1, 2025
Language: Английский
Facile and rapid preparation of fluorinated imprinted adsorbent for magnetic solid phase extraction of liquid–crystal monomers
YueYue Zhang,
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Dingliang Tang,
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Yuanfei Wu
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et al.
Microchimica Acta,
Journal Year:
2024,
Volume and Issue:
192(1)
Published: Dec. 6, 2024
Language: Английский
First report on liquid crystal monomers in tree barks surrounding a display manufacturer: Insights for atmospheric transport and establishment of priority list
Jiong-Feng Xie,
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Jia-Yi Gu,
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Liangzhong Li
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et al.
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
477, P. 135372 - 135372
Published: July 28, 2024
Language: Английский
Facile and rapid preparation of magnetic imprinted adsorbent for specific separation and capture of liquid-crystal monomers pollutants in environmental water and soil samples
Yueyue Zhang,
No information about this author
Dingliang Tang,
No information about this author
Yuanfei Wu
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et al.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
Abstract
Specific
separation
and
extraction
is
a
pivotal
stage
in
the
accurate
quantification
of
liquid
crystal
monomers
(LCMs)
pollutants
complex
environmental
samples.
In
this
context,
new
fluorinated
imprinted
adsorbent
(MIA)
for
magnetic
solid
phase
(MSPE)
was
one-pot
prepared
within
3.5
h
using
4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-4'-ethyl-biphenyl
(DFBP)
as
template
1H,1H,2H,2H-heptadecafluorodecyl
acrylate/vinylanthracene
dual
monomers.
The
structure,
morphology
properties
MIA
fabricated
beneficial
conditions
were
investigated
by
various
characterized
techniques.
Under
optimal
parameters,
presented
satisfactory
specific
recognition
performance.
factor
adsorption
capacity
towards
DFBP
high
2.7
15.9
mg/g,
respectively.
At
same
time,
behaviors
MIA/MSPE
surveyed
means
kinetics
isotherm.
Combining
with
HPLC
coupled
diode
array
detector
(DAD),
sensitive,
reliable
anti-interference
method
monitoring
LCMs
residuals
water
soil
samples
established.
achieved
enrichment
factors
132–248
96–204
samples,
corresponding
limits
detection
0.0017–0.0051
µg/L
0.087–0.28
µg/kg,
Moreover,
confirmatory
experiments
adopted
to
inspect
accuracy
established
MIA/MSPE-HPLC/DAD
approach.
To
best
our
knowledge,
first
time
that
material
isolation
capture
which
have
been
classified
emerging
organic
pollutants.
Language: Английский
Chronic exposure to liquid crystal monomer EBCN at environmentally relevant concentrations induces testicular dysfunction via the gut-testis axis
Jun Wu,
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Daojun Lv,
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Wanmei Lin
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et al.
Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
486, P. 137033 - 137033
Published: Dec. 28, 2024
Language: Английский