Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank DOI Creative Commons

Yiling Huang,

Guangqi Chen, Ning Ma

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

Frailty and poor sleep are both risk factors for delirium, but their joint interactive associations with incident delirium unknown. The study aimed to examine the of frailty status quality delirium. A total 346,846 participants from UK Biobank without dementia, or cognitive impairment at baseline were included. Incident cases identified through International Classification Diseases, Tenth Revision codes. modified-version Fried phenotype was utilized evaluate status. score comprising five characteristics used quantify quality. Cox proportional hazard models applied calculate ratios (HRs) 95% confidence intervals (CIs) associations. Also, interactions on incidence multiplicative additive scales quantified. During a median follow-up 13.8 years, 6554 (1.9%) documented. Prefrail frail individuals had 34% (HR = 1.34; CI: 1.27-1.41) 98% 1.98; 1.78-2.19) increased respectively, compared nonfrail controls. Each 1-point increment in associated 25% 1.25; 1.21-1.28) Healthy significantly counteracted due (P interaction 0.026). In healthy stratification, corresponding HRs (95% CIs) 2.07 (1.86-2.31) 1.28 (0.83-1.97), respectively. Moreover, we observed highest 2.08; 1.83-2.35), evidence an interaction. Both physical higher risk. Achieving could not only lower also greatly offset adverse impact

Language: Английский

Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank DOI Creative Commons

Yiling Huang,

Guangqi Chen, Ning Ma

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

Frailty and poor sleep are both risk factors for delirium, but their joint interactive associations with incident delirium unknown. The study aimed to examine the of frailty status quality delirium. A total 346,846 participants from UK Biobank without dementia, or cognitive impairment at baseline were included. Incident cases identified through International Classification Diseases, Tenth Revision codes. modified-version Fried phenotype was utilized evaluate status. score comprising five characteristics used quantify quality. Cox proportional hazard models applied calculate ratios (HRs) 95% confidence intervals (CIs) associations. Also, interactions on incidence multiplicative additive scales quantified. During a median follow-up 13.8 years, 6554 (1.9%) documented. Prefrail frail individuals had 34% (HR = 1.34; CI: 1.27-1.41) 98% 1.98; 1.78-2.19) increased respectively, compared nonfrail controls. Each 1-point increment in associated 25% 1.25; 1.21-1.28) Healthy significantly counteracted due (P interaction 0.026). In healthy stratification, corresponding HRs (95% CIs) 2.07 (1.86-2.31) 1.28 (0.83-1.97), respectively. Moreover, we observed highest 2.08; 1.83-2.35), evidence an interaction. Both physical higher risk. Achieving could not only lower also greatly offset adverse impact

Language: Английский

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