Coptisine improves LPS-induced anxiety-like behaviors by regulating the Warburg effect in microglia via PKM2
Yiyu Qi,
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Xin Zhao,
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Weizhen Wu
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et al.
Biomedicine & Pharmacotherapy,
Journal Year:
2025,
Volume and Issue:
183, P. 117837 - 117837
Published: Jan. 16, 2025
Language: Английский
Triclosan exposure induces liver fibrosis in mice: The heterogeneous nuclear ribonucleoprotein A1/pyruvate kinase M2 axis drives hepatic stellate cell activation
Xiao Ni,
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Ziyun Wei,
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Yuxuan Peng
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et al.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
294, P. 118113 - 118113
Published: March 30, 2025
Language: Английский
PKM2-mediated metabolic reprogramming of microglia in neuroinflammation
Cell Death Discovery,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: April 6, 2025
Abstract
Microglia,
the
resident
immune
cells
of
central
nervous
system,
undergo
metabolic
reprogramming
during
neuroinflammation,
playing
a
crucial
role
in
pathogenesis
neurological
disorders
such
as
Parkinson’s
disease.
This
review
focuses
on
Pyruvate
Kinase
M2
(PKM2),
key
glycolytic
enzyme,
and
its
impact
microglial
subsequent
neuroinflammation.
We
explore
regulatory
mechanisms
governing
PKM2
activity,
influence
activation
responses,
contribution
to
progression
various
diseases.
Finally,
we
highlight
therapeutic
potential
targeting
novel
strategy
for
treating
neuroinflammation-driven
disorders.
provides
insights
into
molecular
aiming
inform
development
future
interventions.
Language: Английский