Ecotoxicological effects of the neonicotinoid insecticide dinotefuran on springtails (Folsomia candida) at soil residual concentration

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 209, P. 106345 - 106345

Published: Feb. 22, 2025

Language: Английский

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Neonicotinoids and their metabolites in vegetables and fruits in Shenzhen: Human exposure and health risks

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Metabolomics as a Tool for Unraveling the Impact of Enantioselectivity in Cellular Metabolism

Critical Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: March 4, 2025

Metabolomics is an emerging interdisciplinary field focused on the comprehensive analysis of all metabolites within biological samples, making it valuable for areas such as drug development, and environmental analysis. Many compounds, including pharmaceuticals agrochemicals that have been extensively studied by metabolomics are chiral. The intrinsic chirality targets can lead to a selective recognition enantiomers resulting in distinct pharmacokinetic, pharmacodynamic and/or toxicological profiles (enantioselectivity). Given captures instant snapshot organism's metabolic state, serves powerful tool investigate chiral compounds understand enantioselective effects. Herein, systematic compilation scientific literature was performed 48 enantioselectivity studies using were selected. These revealed increasing focus pesticides (77%), use animal models (59%), reliance LC-MS techniques (52%), predominantly untargeted approaches (83%). Enantioselective effects described most studies. This review describes significant advances this highlights unravel role stereochemistry cellular metabolism examination enantiomer-specific Furthermore, elucidates mechanism be further applied other groups compounds.

Language: Английский

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An Occupational Health Assessment of Dinotefuran Exposure in Greenhouse Vegetable Workers: Metabolomic Profiling and Toxicokinetic Analysis

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137989 - 137989

Published: March 1, 2025

Language: Английский

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Azoxystrobin-Induced Physiological and Biochemical Alterations in Apis mellifera Workers of Different Ages

Insects, Journal Year: 2025, Volume and Issue: 16(5), P. 449 - 449

Published: April 24, 2025

Fungal diseases of agricultural crops cause severe economic losses to the growers. For control these diseases, azoxystrobin is one recommended fungicides. This fungicide systemic in action and expected reach floral part treated crop its residue pollen nectar, natural food sources honey bees, which could be collected fed on by thus affecting their health. The purpose this study was determine physiological chemical changes caused bee workers (Apis mellifera L). Workers at 1, 8, 21 days old were with 125, 167, 250 mg/L concentrations for seven days; survival rates, activities carboxylesterase (CarE), glutathione S-transferases (GSTs), cytochrome P450 enzyme (CYP450), catalase (CAT), superoxide dismutase (SOD) enzymes, expression levels immune (Aba, Api, Def1, Hym) nutrition genes (Ilp1, Ilp2, Vg) detected. Our findings revealed that affected workers, particularly 1- 21-day-old who responded stress increased detoxification protective might have costs. Additionally, genes, a decreased trend compared 8-day-old leading reduced resistance external stressors mortality rates. These provide important insights into adverse effects different ages emphasize potential risks colony stability individual recommends an urgent ban such harmful being used fungi agriculture, especially during plant flowering.

Language: Английский

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Simultaneous exposure to avermectin enhances the toxicity of R-dinotefuran and reduces the toxicity of S-dinotefuran

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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