Geostatistical and multivariate analysis of phosphate evolution and its relationship with heavy metals in shallow groundwater in a Semi-Arid Basin

Earth Science Informatics, Journal Year: 2025, Volume and Issue: 18(3)

Published: Feb. 18, 2025

Language: Английский

Single-Nucleus Transcriptomics Reveals Prenatal and Postnatal Pb Exposure-Induced Cell-Specific Neurotoxicity and Dysregulated Microglia-Neuron Communication in Mice Brain

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Lead (Pb) is an environmental pollutant that has lasting effects on neurodevelopment. Children exhibit heightened sensitivity to Pb exposure compared adults, and prenatal can harm the developing fetal nervous system. However, specific regulatory of across various developmental stages are not well understood. This study employed single-nucleus RNA sequencing (snRNA-seq) analyze mice brains at different ages (2 8 weeks) following postnatal exposure. Blood lead level in exposed comparable those detected human samples, implying its implication. A total 43,303 brain cells were sequenced for cell-specific analysis. was found elevate proportion immature neurons 2 week-old perturb neurodevelopment- neural structure-related pathways within neurons. In mice, primarily influenced implicated synaptic transmission, signal transduction, learning memory both glial cells. The communication involving neurotransmitters glutamate γ-aminobutyric acid (GABA), along with their receptors, disrupted between neuron microglia. Through application snRNA-seq, this demonstrated Pb-induced neurotoxicity characterized by cellular heterogeneity disruption neurotransmitter-related microglia could be a critical factor neurotoxicity.

Language: Английский

Distribution, Sources, and Heavy Metal Interactions of Microplastics in Groundwater and Sediment of Semi‐Arid Regions of Northwest India

Land Degradation and Development, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

ABSTRACT Microplastic (MP) pollution is a growing public health concern, yet its presence in groundwater, critical potable water source, remains underexplored. This study investigates MPs groundwater from open and closed well systems, as sediment samples, the semi‐arid region of Didwana‐Kuchaman, Rajasthan, Northwest India. The MPs, identified using fluorescence microscope, were ubiquitous at all sampling sites, with concentrations ranging 3 to 122 particles/L (average = 35.46 particles/L) abundance 170 1140 particles/kg 505.52 particles/kg). Morphologically, beads/pellets within 20–200 μm size range dominated MP while polyethylene polystyrene dominant polymer types. A significant positive correlation ( r 0.65) between concentration open‐well samples was noted, highest values observed near landfills agricultural areas. Heavy metals (HMs) (ppb) ranked following order: As (396.11) > Mn (280.18) Zn (184.67) Co (71.8) Ni (60.56) Pb (24.24) Cr (1.26). hazard quotient derived for both children adults indicates Co, significantly above acceptable threshold (HQ 1), suggesting considerable contamination risk. Although no HMs SEM–EDX analysis revealed adherence HMs, including Ni, As, Cr, Zn, Mn, Pb, surfaces, potential interactions co‐transport mechanisms. results underscore concerning co‐occurrence raising alarming concerns about synergistic effects. highlights urgent need comprehensive risk assessments mitigation strategies addressing HM resources.

Language: Английский