Opposing Visual Impairments Induced by Structurally Similar Organophosphate Flame Retardants TPHP and CDP in Zebrafish Larvae DOI

Yiqun Song,

Ting Xu, Hongchang Zhang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Vision is the primary sensory function for most animals and also a sensitive toxic target of environmental pollutants. A new class organophosphate flame retardants (OPFRs) termed emerging OPFRs (eOPFRs) with limited toxicological information rapidly developed into substitutes traditional OPFRs. In this study, we investigated visual toxicity triphenyl phosphate (TPHP, one OPFR) cresyl diphenyl (CDP, on zebrafish larvae at environmentally relevant concentrations (3 30 nM). After 5 days exposure, an opposite was found between two OPFRs, manifested in light perception gene expressions opsins. CDP caused weak reaction to overall inhibition opsin expression (0.7- 0.8-fold) larvae, while TPHP tended stimulate these events (1.2- 2.4-fold). Besides, identified key transcription factor, tbx2a, that significantly disrupted both OPFRs' exposure. The differing ways which bind Tbx2a may be reason behind their effects. These findings provided clues mechanisms revisited question regarding safe those contaminants.

Language: Английский

Revealing the neurodevelopmental toxicity of face mask-derived microplastics to humans based on neural organoids DOI
Minghui Li, Xue Gao,

Yingying Lan

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138084 - 138084

Published: March 1, 2025

Language: Английский

Citations

0
Aggravated Visual Toxicity of Eco-Corona on Micro(Nano)Plastics in Marine Medaka (Oryzias melastigma) DOI

Yuqing Ma,

Ling Liu, Yanan Xu

et al.

Environmental Science & Technology Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Language: Английский

Citations

0
Opposing Visual Impairments Induced by Structurally Similar Organophosphate Flame Retardants TPHP and CDP in Zebrafish Larvae DOI

Yiqun Song,

Ting Xu, Hongchang Zhang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Vision is the primary sensory function for most animals and also a sensitive toxic target of environmental pollutants. A new class organophosphate flame retardants (OPFRs) termed emerging OPFRs (eOPFRs) with limited toxicological information rapidly developed into substitutes traditional OPFRs. In this study, we investigated visual toxicity triphenyl phosphate (TPHP, one OPFR) cresyl diphenyl (CDP, on zebrafish larvae at environmentally relevant concentrations (3 30 nM). After 5 days exposure, an opposite was found between two OPFRs, manifested in light perception gene expressions opsins. CDP caused weak reaction to overall inhibition opsin expression (0.7- 0.8-fold) larvae, while TPHP tended stimulate these events (1.2- 2.4-fold). Besides, identified key transcription factor, tbx2a, that significantly disrupted both OPFRs' exposure. The differing ways which bind Tbx2a may be reason behind their effects. These findings provided clues mechanisms revisited question regarding safe those contaminants.

Language: Английский

Citations

0