Cyanophage Engineering for Algal Blooms Control DOI Creative Commons
Yujing Guo, Xiaoxiao Dong, Huiying Li

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1745 - 1745

Published: Nov. 6, 2024

Cyanobacteria represent a prevalent category of photosynthetic autotrophs capable generating deleterious algal blooms, commonly known as cyanobacteria harmful blooms (cyanoHABs). These often produce cyanotoxins, which pose risks to public health and ecosystems by contaminating surface waters drinking water sources. Traditional treatment methods have limited effectiveness. Therefore, there is an urgent need for new approach effectively manage cyanoHABs. One promising the use cyanophages, are viruses that specifically target cyanobacteria. Cyanophages serve effective biological control method reducing cyanoHABs in aquatic systems. By engineering it possible develop highly specific strategy minimally impacts non-target species their propagation environment. This review explores potential application cyanophages controlling It includes identification isolation broad-spectrum novel with focus on freshwater Microcystis highlighting broad spectrum high efficiency. Additionally, recent advancements cyanophage discussed, including genome modification, functional gene identification, construction artificial cyanophages. Furthermore, current state addressed. Cyanophage managing environments.

Language: Английский

Extra peptidase of a cyanophage confers its stronger lytic effect on bloom-forming Microcystis aeruginosa DOI
Fei Ke, A. D. Liu,

Qi-Ya Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140979 - 140979

Published: Feb. 1, 2025

Language: Английский

Citations

0
Virus Infection of a Freshwater Cyanobacterium Contributes Significantly to the Release of Toxins Through Cell Lysis DOI Creative Commons
Victoria Lee, Isaac Meza‐Padilla, Jozef I. Nissimov

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 486 - 486

Published: Feb. 22, 2025

Toxic algal-bloom-forming cyanobacteria are a persistent problem globally for many aquatic environments. Their occurrence is attributed to eutrophication and rising temperatures due climate change. The result of these blooms often the loss biodiversity, economic impacts on tourism fisheries, risks human animal health. Of emerging interest poorly understood interplay between viruses toxic species that form blooms. This because recent studies have suggested may exacerbate harmful effects by contributing release toxins into dissolved phase upon cell lysis. However, date, there no experimental evidence explicitly implicates in microcystin release. Here, we show experimentally virus infection toxin-producing, harmful, cyanobacterium Microcystis aeruginosa results 4-fold increase toxin microcystin-LR two days post-infection (dpi). We also concentrations remain high after culture discoloration host Collectively, our directly implicate as major contributors from emphasize importance taking account predictive models assessment water quality safety.

Language: Английский

Citations

0
Cyanophage-encoded auxiliary metabolic genes in modulating cyanobacterial metabolism and algal bloom dynamics DOI Creative Commons

Quratul Ain,

Kevin Wu, Xuan Wu

et al.

Frontiers in Virology, Journal Year: 2024, Volume and Issue: 4

Published: Oct. 1, 2024

Cyanophages play a pivotal role in controlling cyanobacterial populations aquatic environments. These dsDNA viruses harbor auxiliary metabolic genes (AMGs) that modulate the key processes of their hosts, such as Photosynthesis, nutrient uptake for optimization viral replication. Recently, pan1~pan5 and pam1~pam5 cyanophages have been isolated from fifth largest water resource China; Lake Chaohu. Detailed genomic analysis these phages revealed especially Pan1, Pam2 Pam3 possess unique AMGs significantly enhance activities potentially leading to suppression bloom formation stabilization ecological dynamics Our findings provide concrete evidence encoding could serve effective biocontrol agents against harmful algal blooms, offering targeted approach manage environmental threats. The integration cyanophage-based management therapies with traditional methods advance efficiency sustainability outbreaks, paving way novel applications management. This review emphasizes importance critical need further exploration phage-host fully harness potential ecosystem regulation.

Language: Английский

Citations

2
Cyanophage Engineering for Algal Blooms Control DOI Creative Commons
Yujing Guo, Xiaoxiao Dong, Huiying Li

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1745 - 1745

Published: Nov. 6, 2024

Cyanobacteria represent a prevalent category of photosynthetic autotrophs capable generating deleterious algal blooms, commonly known as cyanobacteria harmful blooms (cyanoHABs). These often produce cyanotoxins, which pose risks to public health and ecosystems by contaminating surface waters drinking water sources. Traditional treatment methods have limited effectiveness. Therefore, there is an urgent need for new approach effectively manage cyanoHABs. One promising the use cyanophages, are viruses that specifically target cyanobacteria. Cyanophages serve effective biological control method reducing cyanoHABs in aquatic systems. By engineering it possible develop highly specific strategy minimally impacts non-target species their propagation environment. This review explores potential application cyanophages controlling It includes identification isolation broad-spectrum novel with focus on freshwater Microcystis highlighting broad spectrum high efficiency. Additionally, recent advancements cyanophage discussed, including genome modification, functional gene identification, construction artificial cyanophages. Furthermore, current state addressed. Cyanophage managing environments.

Language: Английский

Citations

0