Mechanisms of PFBA Toxicity in Chlorella vulgaris: Photosynthesis, Oxidative Stress, and Antioxidant Impairment
Environmental Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 121228 - 121228
Published: Feb. 1, 2025
Language: Английский
Integrative Transcriptomics Analysis Reveals Convergent Toxicological Effects of Perfluorooctanoic Acid and Perfluorooctane Sulfonate on Human Liver: Evidence from Multiple Models
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
unknown, P. 138112 - 138112
Published: April 1, 2025
Perfluorooctanoic
acid
and
perfluorooctane
sulfonate
are
well-known
eight-carbon
per-
polyfluoroalkyl
substances
(8C-PFAS)
potentially
toxic
for
the
human
liver.
However,
direct
experimental
evidence
demonstrating
their
toxicity
on
liver
remains
limited.
Consequently,
this
study
aimed
to
extrapolate
8C-PFAS
mechanisms
by
leveraging
omics
data
integrate
mouse
findings.
Through
integration
analyses
of
nine
datasets
(one
human,
six
murine,
two
rat),
we
identified
199
genes
with
known
biological
functions
that
commonly
affected
across
species.
We
delineated
a
comprehensive
regulatory
network
toxicity,
may
trigger
fatty
disease
up-regulating
CD36
PPARα
pathway;
dysregulate
xenobiotic
metabolism
disrupting
CAR
CYP
family
genes;
induce
cancer
dysregulating
WNT,
TGFβ,
FGF21,
P53
pathways.
also
ATF3,
EGR1,
ESR1,
NFATC4,
SNAI2,
TP53,
EZH2
as
transcriptionally
regulated
8C-PFAS,
along
PPARα,
RXRα,
FGFR1,
TCF3,
SMAD3
functionally
impacted.
Collectively,
these
factors
account
over
90
%
8C-PFAS-affected
key
genes.
This
not
only
developed
novel
method
extrapolating
risks
integrating
scattered
based
transcriptomics
data,
but
proposes
new
which
contributes
cancer.
Language: Английский
Per- and Polyfluoroalkyl Substances (PFAS) Composition and Distribution in Surface Water of the Miccosukee Indian Reservation, Everglades and Tributaries in the Coastal Environment of Miami, Florida
C. W. Heath,
No information about this author
A. R. Castañeda,
No information about this author
Edward Ornstein
No information about this author
et al.
Environmental Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 121627 - 121627
Published: April 1, 2025
Language: Английский